InJae Chung
Bob Wyttenbach
Neuroscience Behavioral Biology
October 7, 2015
A critique of “Ehrlich, David E, and Donald G Rainnie. 'Prenatal Stress Alters The Development Of Socioemotional Behavior And Amygdala Neuron Excitability In Rats '.
1.0 Background
The research is discussing the effects of prenatal stress (PS) on the development of socioemotional symptoms as well as neurodevelopmental disorders. The study arises from existing literatures where a significant relationship has been established between prenatal stress and social deficits such as autism and attention-deficit hypersensitivity disorder among children and schizophrenia among adolescents. King et al. identifies exposures to environmental hardships and stressful events as the underlying factor in the development of PS (274). The aspect has a negative impact on the immune and endocrine system as well as neurological development (Charil et al. 56). Studies have revealed that PS affects several aspects of brain development in the fetal stage. It increases rate of cell death and reduces rate of proliferation in the hypothalamus-pituitary axis (Schoenfeld and Gould 15).
The research argues that PS affects the amygdala, a socioemotional control center in the brain that plays a significant role in the pathogenesis of neurodevelopmental psychiatric disorders. The claim is backed by several studies. PS plays a major role in abnormal psychological, cognitive, and behavioral outcomes in both human and animals. Charil
Neural Plasticity is a characteristics which is sustainable throughout life and is the ability to respond and change to experiences as well as the environment (Comb-Orme et al., 2011). According to Combs-Orme, Egan, and Neely-Barnes, neural plasticity means that neuron connections and neurons may develop throughout life. Neural plasticity indicates at the significance of several psychosocial aspects (Comb-Orme et al., 2011). Researchers Combs-Orme, Egan, and Neely-Barnes explain how the ability to store and organize information as well as develop the solution to issues is cognition. The development of cognition advances from less complicated to a more complicated process which initiates at birth until death. Cognitive development depends on neural plasticity’s part in adapting to environmental stimulants (Comb-Orme et al., 2011). Integrating cognition and memory into social work is important for understanding the methods for policy as well as direct practice. Phillips and Shonkoff explain that stress is a set of adjustments taking place in an individual’s body and brain which is set off by a stimulus or risk that is considered traumatic. According to Adolphs, Tranel, and Buchanan believe that the amygdala is an important aspect in emotional memory. The processing of memories may change within the brain depending on if a traumatic event occurs (Comb-Orme et al.,
Several environmental factors have also been suspected of attributing to the cause of autism such as: exposure to infectious disease, heavy metals, phthalates and phenols, pesticides, alcohol, illicit drugs, advanced maternal age, maternal bleeding during pregnancy, maternal medications used during pregnancy and maternal stress (Glasson et al., 2004). The research conducted by Glasson et al., (2004) shows that individuals who were later diagnosed with autism were more likely to have experienced obstetric difficulties during pregnancy, labor, delivery and neonatal period. Advanced maternal age was the strongest finding in that study.
Childhood maltreatment is a prevalent problem through out the world. As a child grows and matures the brain continues to develop according its experiences. During this time sensitive periods of development for different areas of the brain. A few areas that are of interest are the stress-influenced areas, which are at an increased risk for developmental problems when exposed to maltreatment. The extra stress from such exposures can influence abnormalities throughout the brain, which have been linked to structure changes with in the corpus callosum, anterior cingulate, dorsolateral prefrontal, orbitofrontal cortex, and hippocampus, amygdala, and cerebellum, as well as changes to stress related hormone systems. These structural changes are associated with an increased risk of psychopathology and other life long educational and physiological risk.
Throughout life, both children and adults experience varying amounts of stress in their everyday lives. For the most part, this has been proven to be healthy and crucial in strengthening their response to such stimuli later in life. This paper will focus on the findings of various studies in which researchers have found links between stress exposure and childhood development. Specifically, this paper will focus on the effects of what is known as toxic stress and its effects on the development of a child and its role in the development of mental disorders as the child transitions into adulthood.
The prenatal period is when quick changes in the fetal organs are vulnerable to organizing change and stability but also building internal working system to trigger emotional responses (McEwen et al. 2013). It is a critical time for brain development and the PFC (McEwen et al. 2013). It exposes a selection of long -term modifications on brain development and behaviour (Entringer et al. 2009). Prenatal exposure to stress affects hormones in the body including the physiology and anatomy that relate to increasing drug levels, cortical communication and more (Entringer et al. 2009). Fetal stress is any event that interrupts a fetal process in stability in the body. (Entringer et al. 2009). During pregnancy, maternal stress impends the fetal nervous system and shortens the length of maturation due to many issues and concerns affecting the mother (Entringer et al. 2009). During pregnancy, maternal psychosocial stress threatens the fetal nervous system and contracts the length of gestation (Entringer et al. 2009). High levels of placental corticotrophin- releasing hormone
However, to understand the impact of adversity on young children’s development and learning, our genes supply the basic blueprint for brain development. “Thus, toxic stress in early childhood not only is a risk factor for later risky behavior but also can be a direct source of biological injury or disruption that may have lifelong consequences independent of whatever circumstances might follow later in life (Shonoff and Garner, 2012, page 238). Poverty, neglect, or family stress can make it especially difficult for young children to develop the self-discipline and habits of mind they will need to succeed in the classroom and beyond. Researchers have found that chronic, sustained stress, such as that caused by neglect, abuse, or deprivation,
During pregnancy, there are some factors beyond the mother’s control which can have negative significances for the fetus. Maternal stress occurs when the mother is exposed to psychosocial stressors during pregnancy (Kramer et al, 2009). The mother could also develop depression during or after her pregnancy. This mental illness affects the mother’s ability to function and cope with everyday life (NIHCM, 2010), thus affecting her relationship with her baby. Recent research evidence has highlighted that there is some overlap between the symptoms of maternal depression and stress (Cheng & Pickler, 2014), and that these play a role in affecting the normal development of the fetus. However, other research has indicated that stress and depression do not harm the fetus, and in fact can be developmentally beneficial (DiPetro, 2004). In this essay, a number of symptoms of maternal stress and depression shall be addressed, and the extent to which they affect the developing fetus. First to be discussed is how the emotional stability of the mother may affect the relationship she has with her baby.
Talge, N. M., Neal, C, Glover, V., & the Early Stress, Translational Research Prevention Science Network: Fetal and Neonatal Experience on Child Adolescence Mental Health. (2007). Antenatal maternal stress and long-term effects on child neurodevelopment: How and why? Journal of Child Psychology and Psychiatry, 48, 245-261.
The ACE Study was designed to answer the question: “If risk factors for disease, disability, and early mortality are not randomly distributed, what early life influences precede the adoption or development of them (preventchildabuse.org)?” Adverse Childhood Experience does not evoke preconceived notions or biases about the perpetrators or victims of child abuse, domestic violence, or persons with mental health or substance abuse issues. The term “adverse” implies stress. However, the biologic stress response is largely responsible for the negative impact of ACEs on brain development. “Experiences” was the term chosen rather than “Environment” because the latter term can imply exposure to environmental toxins. As framed by the study, “Childhood” refers to the first 18 years of life (preventchildabuse.org).
Collectively, these factors of his childhood could have derailed the healthy development of Chikatilo’s body and brain, because they provided toxic stress that excessively stimulated his stress response system (National Scientific Council on the Developing Child [NSCDC] 2014, p. 1). This can change the architecture of the brain because the fear, anxiety, and impulse regions of the brain may overproduce neural connections, while the regions dedicated to reasoning, planning, and behaviour control will consequently be able to produce fewer connections (p. 2). Persistent fear and anxiety also has the potential to affect learning, and health across the lifespan (p. 1), as well as how people solve problems and relate to other people (NSCDC, 2010a,
It has been said that exposure to prenatal maternal stress can have lifelong consequences resulting in problems with child cognitive development and motor skills as young as the age of 16 months. The researchers that conducted this study hypothesized that the severity of objective hardship and subjective stress reactions would predict different aspects of child development.
Another important part of this study was looking at how these effects occurred during different stages of prenatal development, as the “consequences of prenatal maternal stress were determined by the
Technological advances in the past decade have allowed scientists to study the brain in ways that have led to new understanding about how young children develop. There is a new understanding of both the capabilities and the vulnerabilities of infants and young children and that understanding is has influenced the work of caregivers and teachers. During pregnancy, the basic architecture of the brain is formed. Although, certain experiences do influence the developing brain during pregnancy, such as maternal health and stress, intake of drugs and/or alcohol, and quality of maternal nutrition.
To continue the research, Jordan Smoller distinguishes this section of the genetics of anxiety, “…the majority of the genetic association studies of the anxiety disorders have been candidate gene studies based on a limited number of biological hypotheses. [These are] commonly focused on genes related to monoaminergic neurotransmitter systems [(refer to the particular neurotransmitters dopamine, noradrenaline, and serotonin)], neuropeptides, and HPA axis function [(hypothalaic-pituitary-adrenal axis)]” (Smoller, p. 308). Individually, settled test creature models catch critical parts of human nervousness and dread conduct, and neuroimaging considers have gained free ground in mapping the primary and practical segments of uneasiness/fear symptoms.
According to the article, “Stress and Child Development” (2014) by Ross Thompson, stress is defined as “a complex psychobiological process with biological, emotional, mental, and behavioral consequences, all of which influence one another” (Thompson, 2014, p.46). Thompson’s research provided insight into helping children who suffer from stress, and cope with this stress through neurobiological processes, including two-generation and multi-generation intervention, which includes parents, teachers, relatives and grandparents or anyone who provides care for these children. Thompson’s research found that children who grow up in a loving environment are less stressful, and when confronted with stress, these children cope with stress better than children who live in a non-loving environment. Thompson suggested that stress is brought on when an individual feels threatened or when her or she feels surrounded by, or in immediate danger, thus, emphasizing how a child’s social experiences plays a key role in the development of a child’s neurological systems as well as his or her biological system (Thompson, 2014). Thompson’s research of Hurricane Katrina found that children whose parents could no longer provide care for their children faired much worse than children whose parents provided care, as it relates to stress. Thompson’s study of a Romanian orphanage found that the sooner a child was adopted into a loving environment, the sooner a child learned how to cope and