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Advantages And Disadvantages Of Nmps

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Introduction Every year, thousands of individuals worldwide are affected by Spinal Cord Injury (SCI), a devastating neurological disorder that, unfortunately, remains without an effective therapy, since the current approved approaches are essentially palliative1. Several types of new therapeutic strategies, including cellular, molecular and combinatorial approaches, have been studied in the recent years. Cell therapies, aiming particularly at replacing lost neurons and recovering the neuronal circuitry, are typically seen as holding a great potential for changing the paradigm towards more curative interventions. Numerous approaches are being developed, each one having its own advantages and disadvantages as it has been reviewed elsewhere1, …show more content…

It has already been proposed that NMPs might prove to be particularly relevant, not only for their potential to give rise to specific SC neuronal cell types, which can be expected to confer greater functional improvements in patients, but also because NMPs seem to have fewer safety issues, since they passage poorly and differentiate quickly, thus presenting a lower tumor formation risk5. Nevertheless, the full concretization of this potential will only be achieved when we gain a more complete understanding of the precise molecular identity of NMP cells and of the regulation of their transcriptional networks by extracellular signals, features that, until now, remain …show more content…

This would represent a major technical advancement and gives a new hope for the development of the desired effective spinal cord regeneration therapies. Notwithstanding, it is still necessary to refine the methods for differentiation of NMPs into spinal cord motor neurons and to guarantee that the specific neuronal subtypes are generated with precision. In turn, this refinement will require a more complete understanding of NMPs and their differentiation, and also of the molecular mechanisms involved in the DV patterning of the spinal

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