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Amyotrophic Lateral Sclerosis

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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease, which means there’s an increasing loss of neuron structure and function as the disease progresses. This is when there’s an unusual hardening of body tissue due to a lack of muscle nourishment and poor nerve cell transmission. ALS typically affects the ages of 40-70 years old, and for some unknown reason, military veterans are almost double the chance of developing ALS in comparison to the general public. The first large-scale effort to track ALS and its outcomes is the ALS CARE Database, where it stated that, of the people in the database, 60% were men, and 93% were Caucasian (Amyotrophic Lateral Sclerosis (ALS) Fact Sheet, 2016). There are 2 main types of ALS; sporadic and …show more content…

Although it is not known how the SOD1 gene leads to ALS, there is increasing evidence that mutated SOD1 can become toxic. It was suggested that the changes in processing RNA molecules, the ones associated with gene regulation and activity, could be a factor to causing ALS, due to the discovery of certain genetic mutations, but it’s just a possibility. In 2011, there was a defect in the C9orf72 gene which was found in both ALS patients and some frontotemporal dementia patients, and suggests the genetic ties between both neurodegenerative disorders (Amyotrophic Lateral Sclerosis (ALS) Fact Sheet, 2016). Consequently, due to no concrete causes, there can be no definitive diagnosis. In order to detect ALS, a series of tests must be done, as it is diagnosed through the process of elimination. Some diagnostic testing includes an electromyography, which detects electrical activity in muscles. Magnetic resonance imaging (MRI) can also be done to show a detailed picture of the brain and spinal cord. A muscle and/or nerve sample from the body can be examined, as well as urine and blood …show more content…

Under normal conditions, satellite cells are inactive, but become activated when there’s a serious injury, and when muscles lose their nerve supply. Satellite cells repair muscle fibres, but when they become old, they disrupt signals and skeletal muscle cannot be prepared and regenerated effectively. This results in muscle fibre degeneration, an increase in connective tissue between single muscle cells, and weakens the single muscle cell and neuromuscular junction connection (Tsitkanou, Della Gatta, Russell,

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