Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease, which means there’s an increasing loss of neuron structure and function as the disease progresses. This is when there’s an unusual hardening of body tissue due to a lack of muscle nourishment and poor nerve cell transmission. ALS typically affects the ages of 40-70 years old, and for some unknown reason, military veterans are almost double the chance of developing ALS in comparison to the general public. The first large-scale effort to track ALS and its outcomes is the ALS CARE Database, where it stated that, of the people in the database, 60% were men, and 93% were Caucasian (Amyotrophic Lateral Sclerosis (ALS) Fact Sheet, 2016). There are 2 main types of ALS; sporadic and …show more content…
Although it is not known how the SOD1 gene leads to ALS, there is increasing evidence that mutated SOD1 can become toxic. It was suggested that the changes in processing RNA molecules, the ones associated with gene regulation and activity, could be a factor to causing ALS, due to the discovery of certain genetic mutations, but it’s just a possibility. In 2011, there was a defect in the C9orf72 gene which was found in both ALS patients and some frontotemporal dementia patients, and suggests the genetic ties between both neurodegenerative disorders (Amyotrophic Lateral Sclerosis (ALS) Fact Sheet, 2016). Consequently, due to no concrete causes, there can be no definitive diagnosis. In order to detect ALS, a series of tests must be done, as it is diagnosed through the process of elimination. Some diagnostic testing includes an electromyography, which detects electrical activity in muscles. Magnetic resonance imaging (MRI) can also be done to show a detailed picture of the brain and spinal cord. A muscle and/or nerve sample from the body can be examined, as well as urine and blood …show more content…
Under normal conditions, satellite cells are inactive, but become activated when there’s a serious injury, and when muscles lose their nerve supply. Satellite cells repair muscle fibres, but when they become old, they disrupt signals and skeletal muscle cannot be prepared and regenerated effectively. This results in muscle fibre degeneration, an increase in connective tissue between single muscle cells, and weakens the single muscle cell and neuromuscular junction connection (Tsitkanou, Della Gatta, Russell,
ALS is also known as Amyotrophic Lateral Sclerosis is a disease in which the brain, nerves, and spinal cord deteriorate. It attacks every part of the body except the brain. Causing major body malfunction along with muscle weakening. Which includes lack of strength, the ability to move arms, legs and body, eventually you lose the ability to breathe. The average time of life after being diagnosed is two - five years. It was believed to be inherited or maybe an infection. After years of research scientist have found a major
Amyotrophic meaning, “no muscle nourishment” in Greek, lateral meaning where the neurons are in the spinal cord, and sclerosis meaning “scarring.” ALS, often known as “Lou Gehrig’s Disease,” named after the New York Yankee who first brought awareness to the disease in the late 1930’s, is a neurodegenerative disease, which affects the neurons in the brain. The nerve cells in the brain and spinal cord that are responsible for sending and receiving motor signals progressively die off, causing the deterioration of simple motor skills in patients with ALS, such as walking, talking, and eventually speaking and breathing, however thinking is not affected by ALS. Early symptoms cause the person to slowly lose mobility of limbs, but in a matter of a few years, the person loses the mobility of most of their body and will eventually lose the ability to eat and breath, which will ultimately cause death. ALS deteriorates the patient's body, however does not affect the patient's state of mind or sanity while the rest of the body shuts down. People usually get ALS between the ages of 40 and 70. However, there is a growing trend where athletes are getting ALS in their thirties. ALS can be contributed to genetic predisposition, which means that the gene that is responsible for ALS is already in the person’s DNA. In recent studies, however, it was observed that individuals who have had suffered multiple concussions or any other head trauma are
Have you ever heard of ALS, better known as Lou Gehrig’s disease? For many people, ALS is a disorder that they may not know much about. I never heard of it either until my father was diagnosed with this disease in 2006. Because there is no known cure, it is important to detect this disease early, so that proper treatments and preparation can be done before it’s too late.
Following the diagnosis of ALS the main goal of treatment is focused at relieving the symptoms. The most important matter in managing ALS patients is that they continually sustain the highest amount of movement and activity as possible and remain comfortable while doing so. Although a cure for ALS has not yet been developed, effective treatments do exist to assist the patients in their fight with the disease. Physicians urge the patients to carry on with their everyday lives doing all the activities and physically exerting themselves as they would normally do. But, they also recommend the patients to limit their amount of physical exertion
People first need to know what ALS is. ALS is very difficult to diagnose. So far there is no
Lou Gehrig’s Disease Thesis: Weakness in the hands, arms, legs or slurred speech. Imagine having these symptoms and not knowing what is wrong. Then the most dreaded words are uttered, “You have Lou Gehrig’s Disease”. Amyotrophic Lateral Sclerosis (ALS), or other wise known as Lou Gehrig’s Disease, is a disease that attacks muscles and brain cells. “ALS was first found in 1869 by French neurologist Jean-Martin Charcot,but it wasn’t until 1939 that Lou Gehrig brought national and international attention to the disease” (About).
ALS is usually diagnosed in people between 40 to 70 years old, and more common among caucasians. “For unknown reasons, military veterans are twice as likely to be diagnosed with the disease than the general public”(ALS association: What Is ALS?). Although, even with this statistic on it, anybody can get ALS. Symptoms for ALS are so generic that they are overlooked most of the time.
There are many factors that may determine how the disease affects an individual. The first factor is how much muscle and fat the victim had before Amyotrophic Lateral Sclerosis began wasting the muscles away. Smoking has been thought to double a person’s risk of developing ALS, although it has not yet been proven. Military service seems to also have an effect on who contracts ALS. Military men and women have the chance of being exposed to various metals, infections, exertion, chemicals and trauma that can affect the impact of
Amyotrophic Lateral Sclerosis (ALS) is a terminal disease, also known as Motor Neurons Disease, Charchot Disease and Lou Gehrig disease. ALS destroys the Central Nervous System (CNS) and causes damage to the upper and lower motor neurons in the brain. Signs and symptoms are characterized as: muscles weakness, muscle atrophy, twitching and reduced muscle reflexes. Eventually the patient will become paralyzed and rely on a tracheostomy and ventilator for breathing (ALS Association [ALSA], 2010).
The causes of getting ALS are getting multiple hits to the head, may not be all at once. It can cause serious problems that affects the daily life, for example hard to walk, speak, swallow, and breathe. People are being diagnosed with ALS at the ages of 40-70 with an average of 55 years. New studies state that athletes are being diagnosed at a younger age do to getting multiple hits to the head related to being in sports. After being diagnosed your life expectancy is 3-5 years, however it can increase with therapies and riluzole which is a drug and is very expensive. The disease isn't cured, it just slows down the disease. A well known person who had ALS is Lou Gehrig, he was a baseball player for the New York Yankees and was in the Hall of Fame in 1939. Started showing symptoms of ALS in 1938 and died on June 2nd
ALS is more commonly known as Lou Gehrigs disease. The progressive disease poisons the nervous system by a chemical that is released after a blow to the head; this chemical is known as Tou. Tou is released into the brain after a blow, poisoning the nervous system causing body muscles to shut down.
There are 20,000 new cases of ALS diagnosed each year in the United States. This yields an incidence of 3 per 100,000 (Brown, 2006). There is no known cause for ALS in 95% of patients; however, 5% have an identifiable genetic mutation (Elman, 2016). The disease can present in individuals less than 30 years of age, but peaks between 40 and 60 years of age. Before the age of 65, more diagnoses are made in men; after the age of 65, gender incidence is equal. There is no clear-cut ethnic or racial predisposition in ALS (Ricks, 2016). The lifespan is approximately 3-4 years after diagnosis. However, in 10 % of
Imagine you are a 78-year-old man, a beloved professor from Brandeis University. Every day you take notice of the increased difficulty of breathing, more so than the usual, or the out-of-breath feeling from climbing a flight of stairs. About two or three weeks later, you start to feel the muscles in your body cramping up, even while partaking in slight activity, And then you know it’s serious after you gave up dancing. After multiple testing, your results come back and you have ALS, also known as Amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis, otherwise known as ALS or Lou Gherig’s disease, is a neurological disease which attacks nerve cells causing them to die and leave the muscles paralyzed. People with ALS lose strength and control of muscles, weakening them and causing them to start to wear away. Eventually the muscles stop working all together and cause paralysis in places such as arms, legs and other parts of the body. When the nerve cells in the diaphragm and chest wall are attacked and the muscles are paralyzed, the person can lose the ability to breathe without assistance, or sometimes at all. Respiratory failure is the cause of death for most people with ALS. Currently there are approximately 2500-3000 Canadians that are living with ALS and according to www.als.ca “Every day two or three Canadians die of the
Summarizing the presented information, all the mentioned methods have added each other enriching the knowledge about the factors resulting in ALS. A factor of crucial importance is that all the methods allowed examining the pathology of ALS in vivo. Furthermore, studies in vivo have been approved boosting the detection of ALS at very early stages including genetic prognoses in the pre-symptomatic stage of the disorder. Thus, combining various methods of medical investigation offers the best opportunities for exploring the pathology of