Najua Gassant
October 15, 2014
Anatomy and Physiology Lab
Bone Pathology OSTEITIS DEFORMANS (PAGET’S DISEASE)
There are 206 bones of the human skeleton. Bone is a connective tissue that are considered organs. Bones are composed of collagen and a mineral called hydroxyapatite, it gives the bones its incredible strength. The bones are important structures in the body for several reasons they support, protect, produce hormones, store minerals and growth factors and allows the body to move. Homeostatic imbalance of the bone can result in diseases of the bone such as Osteitis Deformans, which causes a weak growth of development of bones.
Osteitis Deformans also
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More times than not the disease is asymptomatic and is accidentally diagnosed. People that don’t have symptoms generally find out during diagnostic testing. The diagnostic tests that are used are blood tests, x-rays and isotope bone scans. Signs that a patients has the disease is high amounts of serum alkaline phosphatase in blood tests. X rays and bone scans are used to confirm the diagnosis. X rays give the conclusive diagnose but aren’t really needed, whereas bones scans determine the extent and tells what areas of the bones are being effected (Josse, et al. 4-5) Patients with a more progressive form of Paget’s disease are susceptible to other complications of the body. Secondary complications associated with Pagets can be neurological, cardiac, and skeletal. A few of the complications is fractures, secondary osteoarthritis, deafness, compression of the nerves, hypercalcemia and osteosarcoma, which is rare. (Walker, …show more content…
Managing Pagets Disease gives relief to individuals with the disease. You can manage Paget’s though the methods of therapy and medication. When trying to advise a treatment plan, there are specific criteria the patient must meet to receive treatment, it often depends if the patient is asymptomatic or symptomatic. If the patient I asymptomatic and are not at risk of secondary complications they don’t really need a treatment but the patient is often monitored by clinical reviews. Patients that are symptomatic are given treatment because they have more bones effected by the disease and complication risks. (Oliveira, Lojo, Eslava,
difficult to work with because each case is different, and the course of this disease is
Exploring the Skeletal System The precise number of bones in the adult human skeleton varies from one person to another, but on average there are 206 bones varying shapes and sizes. The skeleton is divided into two main parts. The central bones of the skull, ribs, spin (vertebral column) and breast bone (sternum) form the axial skeleton. The bones of the arms and legs, along with the shoulder blade (scapula), collar bone (clavicle) and pelvis make up the appendicular skeleton.
Per the IME report by Dr. Sultan dated 11/10/15, the patient is to continue PT 2-3 times a week for the lower back, along with home exercises to his right shoulder. Attached is the addendum to the IME report dated 11/19/15.
Two other diseases are associated with Paget’s, a rare type of bone cancer called osteosarcoma, this type of cancer occurs in less than 1 in 1,000 people with Paget’s disease. Acute onset of
Then, characteristic x-ray signatures and elevated total alkaline phos-phatase (ALP) levels confirm the disease and bone scans and individual bone x-rays determine the extent of damaged areas. However, total ALP levels remain within reference levels as long as the disease is monostotic, that is, involving a single bone. Total ALP is not a marker until remodeling has gone far astray in several bones that are grossly misshapen. And, because it is widely recognized that prevalence and severity of PDB is decreasing in the world population, total ALP levels remain within reference ranges far longer, making anecdotal discovery rare. Although there is no cure for PDB, early detection is vital for commencement of diet, exercise, and drug regimens that significantly mitigate debilitating symptoms and disease progression.
The severity of this condition can be classified into 4 different types based on the Brooker classification. But the simpler classification model only has 3 levels, going from grade A all the way to grade C. Grade A is the least severe, to be classified as this the bone fragments have to be less than 1 centimeter and there has to be at least 1 bone island. Grade A basically means the presence of a bone fragment in the tissue but it is so small it is practically irrelevant. Grade A is the only classification where heterotopic ossification is not present. Grade B on the other hand is classified when there is still at least 1 bone island but they are at least 1 centimeter in length instead of less than 1 centimeter. There also has to be a presence of bone spurs in the femur or pelvis, plus the different bone surfaces have to be 1 centimeter apart. The final of the simpler, 3 grade,
Pagets Disease is a non-infectous disease effecting any part of the skeletal system of the host, but usually found in the skull, spine, plvis, thigh bone, shin and the bone in the upper arm, This causes the bones to enlarge and become weak. The cause for Pagets Disease is currently unknow but to not be confused with the unrelated skin condition that bares the same name.
Paget disease is a chronic condition characterised by lesions of bone resulting from disordered remodelling in which excessive bone resorption initially results in lytic lesions followed by disorganized and excessive bone formation (Gracia et al 2012).
Summarize the epidemiological findings for relationship between PA and this disease in terms of mode, duration, intensity (be sure to address dose response)
Clinical manifestations of osteoporosis include back pain caused by a fractured or a collapsed vertebra, Loss of patient height over time, stooped posture, and also bone fracture which occurs more easily than expected. Clinical manifestation for Paget’s disease depend on the affected part. Manifestations include hip pain, hearing loss or headache due to the overgrowth of skull bone, pain, numbness, and tingling in the arm or
Boneless", had osteogenesis imperfect (OIF, 2015b). Additionally, medical literature from the 1600 's includes symptoms and features commonly associated
After the first field trip of fifth grade we had some time to play outside because we missed all of are recesses . So while we were outside my friends and I found this big puddle my friends dared me to jump in. They started chanting so I decided to do it when I jumped I felt the water fill in my shoes my socks were soggy my clothes were moist. when I was finished with my dare I got asked to do one more thing and that was to jump over the puddle instead of jumping over it I jumped right in the center of it .
The vertebral body is mainly made of spongy (cancellous) bone tissue, which is made up of trabeculae. The lamellae are arranged in an open latticework (trabeculae) and the spaces between are filled with bone marrow, which all contribute to decrease the forces applied to the bone. Spongy bone is often aligned along stress lines, helping to prevent breakage/fractures as well as to evenly distribute the forces applied to the
Osteopathic medicine can be defined as the medical approach to the bodies natural ability to heal itself. DO’s practice osteopathy by looking at the patient as a whole while providing treatment that promotes the bodies natural healing process, most likely through OMM (Osteopathic Manipulative Medicine). An MD and DO obtain the same Doctorate level degree, however, DO’s receive an extra training course of OMM- proving them with more medical-related training then an MD. This OMM has a strong foundation of principles, that in my opinion, are necessary for emergency and primary care physicians. DO’s are the frontier for patient care and hopefully, within the next couple of years, DO patient care techniques will be taught in various medical degree seeking applications across the world.
Bone serves the organism at multiple levels: As a system, bones permit the organism to locomote effectively and to maintain posture by bearing loads without deformation, by providing rigid attachment sites for muscles and acting as a system of levers to amplify small movements. As an organ, bones protect the viscera and house the hemopoietic tissue (red marrow). As a tissue, bones serve as a reservoir of readily mobilizable calcium, an