DESCRIBE THE STRUCTURAL COMPARTMENTATION OF MAMMALIAN CELLS
AND THE DIFFERING FUNCTIONS OF THESE COMPARTMENTS
All mammalian cells are eukaryotic, and whilst the eukaryotic type of cell is not exclusive to mammals, mammalian cells differ from other eukaryotic cells because of the organelles that are or are not present. For instance some plant cells have chloroplasts which are not present in mammalian cells, but both plant cells and mammalian cells are eukaryotic in nature. The term eukaryotic refers to the cell having specific membrane bound organelles, which are not present in prokaryotic cells. The defining feature of a eukaryotic cell is usually its membrane bound nucleus (the exception being the red blood cell) [1].
Because of
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The small ribosomal subunit, amongst other things, is initiates the engagement of the mRNA and is responsible decoding the genetic information during translation [4].
The endoplasmic reticulum is specialised for protein processing and lipid biosynthesis. One of its primary functions is to regulate the ionic concentration in the cytoplasm via the movement of Ca2+, via ionic pumps and channels. It also contains enzymes responsible for the metabolising of drugs. Endoplasmic reticulum (ER) can come in two forms. As depicted in Fig. 2 Rough ER has ribosomes present as part of the membrane of the organelle, and together with these ribosomes takes polypeptides and amino acids from the cytosol and synthesises proteins destined for attachment to cell membranes. It is in the lumen of the rough ER that the proteins are folded into the specific three dimensional shapes that are so important for biochemical recognition and linking sites [6]. It is called rough because of the presence of ribosomes makes the surface of the membrane look rough, unlike smooth ER, which lacks the ribosomes so the membrane looks smooth. Rough ER is composed of a large but convoluted flattened sac. The main function of the smooth ER is the production of lipids and the metabolism of compounds (such as the breakdown of glycogen into glucose). Because of the different functions between the rough and smooth ER, different specialised cells will have different amounts of each; for example, hepatic
Eukaryotes include all living animal organisms other than the eubacteria and archaea. The eukaryote has a nucleus membrane that surrounds the nucleus in which the way they defined the
serve as the site of lipid synthesis in the cell. The ER functions as the
Then the tRNA molecules link together and transfer the amino acid to the ribosome. An Anticodons pair with a codon takes the
Currently, there are two major competing theories for the endosymbiotic origin of eukaryotic cells. The first theory claims that the eukaryotic cell is a combination of an archaeon with a
Analyze the anatomical structure of ten different organelles in the cell and their respective functions.
There are two main types of cells in the world. The simplest cells such as bacteria are known as Prokaryotic cells, and human cells are known as Eukaryotic cells. The main difference between each of these cells is that a eukaryotic cell has a nucleus and a membrane bound section in which the cell holds the main DNA which are building blocks of life.
Now that we understand the properties of life and the composition of cells, we can focus on the architecture or formation in terms of basic anatomy and physiology as our second area of exploration. The two types of cells (prokaryotic and eukaryotic) defined before have a few common things such as Plasma membrane (similar to animal cells); Cell wall (similar to plant cells); and Ribosomes, the
The tertiary structure of a protein molecule, or of a subunit of a protein molecule, is the arrangement of all its atoms in space, without regard to its relationship with neighboring molecules or subunits. Tertiary structure is simply the grouping of different separate secondary structures, such as multiple helices or multiple sheets or a combination of helices and sheets.
The association of FMRP with ribosomes is mRNA dependent via large ribonucleoprotein (RNP) particles. RNP particles contain other proteins including FXR1P, FXR2P, YB-1, CYFIP1, CYF1P2, NUFIP1 and nucleolin.
There are several different organelles which allow the cell to carry out its function which is reproduction and growth. There are important organelles that the eukaryotic cell needs, one of which is that the nucleus is present. The nucleus acts as the brain of the eukaryotic cell. DNA is found in the nucleus which holds all the genes and also controls the cell. The cells function is to reproduce, which needs the nucleus to do this. To carry out another function which is to reproduce, the chromosomes which are found in the DNA are needed and copied. The cell also needs a lot of energy for this. The energy is created by the eukaryotic cell’s other organelle which is mitochondria. The mitochondria make energy out of food and then give the cell the energy it needs to carry out its function. The lysosome then digests enzymes which breaks down the
Smooth Endoplasmic Reticulum (Smooth ER) – The smooth endoplasmic reticulum is very similar in terms of structure and chemically to the rough endoplasmic reticulum with the exception of not being able to attach ribosomes like the rough ER can. The smooth ER has more than just one main function and in simple terms these are control of calcium release within the muscle cells, breakdown of lipid soluble toxins in the liver and lipid steroid hormone synthesis. It primarily makes and process fat within a typical animal cell. The structure of the smooth ER is usually said to be tubular rather than sheet like and it may be separate from the rough ER or in some cases may in fact be an extension of it. The smooth ER is said to be most common in cells that metabolise fat and it is a continuation of the outer nuclear membrane of a cell. It is made up of a vast network of membrane which is usually covered in tubules and vesicles. Depending on the type of cells, the amount of rough and smooth endoplasmic reticulum that is present within it varies somewhat greatly. Endoplasmic means inside of the cytoplasm and the term reticulum means network. Rough Endoplasmic Reticulum (Rough ER) – The surface of the rough endoplasmic reticulum is covered in ribosomes which are
The plasma membrane is the outermost layer of a eukaryotic cell. It is made up of phospholipids and proteins. The plasma membrane also functions as the selective boundary of the cell. Unlike a prokaryotic cell, a eukaryotic cell has a nucleus. The nucleus is responsible for the storage and the protection of the DNA of the cell. Most eukaryotes possess a endomembrane system. The endomembrane consists of a endoplasmic reticulum, the golgi apparatus, and vesicles. The endomembrane makes lipids and membrane proteins and sends them where they need to go in the cell. Mitochondria are important parts of eukaryotic cells because they transfer the energy needed for the ATP from food molecules. Lastly, one of the major components of a eukaryotic cell is the cytoskeleton. The cytoskeleton is made up of actin microfilaments, microtubules, and intermediate filaments. The cytoskeleton gives the structure of the eukaryotic cell support. It also assists with the division of the cell and it controls cellular
Eukaryotic cells - found in animals, plants and fungi. In eukaryotic cells, the DNA is sectioned off from the cytoplasm in its own membrane compartment called the nucleus.
Bettelheim, Brown, Campbell and Farrell assert that polypeptide chains do not extend in straight lines but rather they fold in various ways and give rise to a large number of three-dimensional structures (594). This folding or conformation of amino acids in the localized regions of the polypeptide chains defines the secondary structure of proteins. The main force responsible for the secondary structure is the non-covalent
Organelles are the internal structures of the cell that are important for the cell to survive. Each organelle has a specific function for the cell. The types of organelles in the cell can be different from each other depending on the type of cell. Plant cells and animal cells both have a cytoskeleton, endoplasmic reticulum (smooth and rough), golgi apparatus, mitochondrion, nucleus, plasma membrane, and ribosomes. Animal and plant cells also have vacuoles, but they are rarely found in animal cells. Vacuoles in animal cells are very small compared to the vacuoles in plant cells. Lysosomes are also rarely found in plant cells but mostly found in animal cells.