Introduction:
Diabetes mellitus (DM) is a group of metabolic diseases characterized by high blood sugar levels over an extended period of time. With symptoms including increased urination, thirst, and hunger, diabetes is mainly due to loss of insulin production in the pancreas or lack of response to insulin produced. As of 2015, nearly 415 million people worldwide have diabetes with the three main types being Type 1, Type 2, and gestational. 90% of all diabetes cases are Type 2 (T2D) which is characterized by insulin resistance, high blood sugar, and lack of insulin. Also known as noninsulin-dependent diabetes mellitus (NIDDM), this disease is primary caused by obesity and lack of exercise in genetically predisposed people and affects in nearly 29 million people in the US alone, making it the 7th leading cause of death in the country (American Diabetes Association 2016).
The goal of a diabetes treatment plan is lowering HbA1c to below 7.0%, maintaining good glycemic control. Glycated hemoglobin or HbA1c is a blood sugar test that reflects the average plasma glucose concentration over the past three months. The first and best course of treatment is always lifestyle changes that includes exercise, diet modification, and weight control. Unfortunately, when this management plan fails or is insufficient, the next option is to take medications to lower HbA1c. Five non-insulin pharmacological options are available. First, biguanides in the form of metformin are quick
Type II Diabetes, also known as diabetes mellitus, is also called non-insulin-dependent diabetes or aadult onset diabetes. It is a medical disorder that, due to a number of factors codependent with the modern world, is characterized by higher than normal blood glucose levels that play havoc with insulin deficiency and resistance. Insulin resistance means that cells do not respond appropriately when there is free insulin in the blood system. Essentially, they body is reacting to an improper balance of sugars and insulin. Because obesity is often present, research suggests that even thought the mechanisms controling glucose and insulin are unclear, the adopose tissue likely
Diabetes Mellitus (DM) is a chronic dysfunctional metabolic disorder characterized by elevated blood glucose levels (Hyperglycemia). Currently, the causes of this disease may be an inadequate amount of insulin produced by the pancreas, cells in the body are resistant to insulin, and the pancreas producing less insulin than average. There are two main types of diabetes: Type I and Type II. Primary care physicians and endocrinologistendocrinologists can provide guidelines on diseases and treatment for each type of Diabetes Mellitus. Diabetes Mellitus, secondary to pancreatic disease (type 3C), is a condition rarely considered in everyday practice.
Type 2 diabetes (formerly called non-insulin-dependent diabetes (NIDDM), obesity related diabetes, or adult-onset diabetes) is a metabolic disorder that is primarily characterized by insulin resistance, relative insulin deficiency, and hyperglycemia.
Type 2 diabetes mellitus (T2D) is the most common form of diabetes (American Diabetes Association, 2012). T2D is so prevalent that it is estimated to be the fifth most common cause of death worldwide (Yates, Jarvis, Troughton, and JaneDavies, 2009, p. 1). T2D manifests when the body is unable to metabolize glucose properly, resulting in elevated blood sugar, debilitating fatigue, and other serious complications such as distal limb amputations, kidney failure, and blindness. The generally accepted causes of T2D include diet, sedentary lifestyle, and obesity.
"Diabetes mellitus," notes a 2010 San Diego health assessment posting, "is a disease of abnormal carbohydrate metabolism, in which the level of blood glucose, or blood sugar, is above normal. The disease occurs when the body is unable to produce or use insulin, a hormone that helps move glucose from the blood into other cells throughout the body" (San Diego County, n.d.). Type 1 generally reflects a naturally occurring demonstration of this; Type 2 is associated with adjustments that the body makes as a result of sugar and fat intake, and thus aligned very directly with obesity and poor health and dietary concerns. An estimated 90% to 95% of the conditions are now Type 2, contributing
Diabetes Mellitus (DM) or Type 2 Diabetes is seen as a metabolic disease that is categorized by abnormally high blood glucose or hyperglycemia. Diabetes Mellitus is also formerly known as noninsulin-dependent diabetes mellitus and is the most common form of diabetes that is seen. Insulin is a hormone that is supplied to the body that allows us to efficiently use glucose as fuel. When carbohydrates are broken down into sugars in the stomach glucose enters the blood circulation simulating the pancreas to release insulin in an appropriate amount to become used for energy. With diabetes mellitus the body does not properly make use of the insulin supplied for the body. This causes the pancreas to produced an extra amount if insulin which the body cannot keep up with, causing an imbalance to the blood glucose levels (American Diabetes Association, 2015). In the united states diabetes affects almost 29.1 million people, while the another 86 million people have pre-diabetes but do not know. It is also known as the 7th leading cause of death in the country in the recent years (MedicineNet.com, 2016). For a patient suffering from a chronic form of diabetes mellitus understanding how these mechanisms lead to the condition can be used as preventative measures. Potential consequences as well as the causes and clinical manifestations will ensure a better knowledge on the issue to monitor the condition.
Diabetes mellitus, is the fancy way to say diabetes but many people referred it as diabetes. Diabetes is a group of metabolic diseases which can cause you to have high blood sugar levels over a long period. The two main types of diabetes are type 1 and type 2. Type 1 results from the pancreas's failure to produce enough insulin. This form was previously referred to as "insulin-dependent diabetes mellitus" or "juvenile diabetes". The cause is unknown. Type 2 begins with insulin resistance, a condition in which the cells fail to respond to insulin properly. There is no known preventive for type 1 diabetes, Or Type 2 diabetes which accounts for 85-90% of all cases can often be prevented or delayed by maintaining a normal body weight, engaging
Diabetes is a disorder that is formed by high blood glucose. Diabetes is the seventh leading cause for death in the United States. It occurs most often in adults, but it’s one of the most chronic disorders in children. Individuals suffering from hyperglycemia have low production of insulin. American Diabetes Association is trying to prevent and cure diabetes and improve the lives of all people affected by diabetes.
Type 2 diabetes is the most common form of diabetes which affects 90% to 95% of the population. In the United States, approximately 1.7 million new cases of diabetes were identified in 2012 and the disease affects 29 million Americans, or 9.3 percent of the population (Statistics About Diabetes, 2014). In 2012, the total financial burden of diabetes was estimated to be $245 billion which included $176 billion in direct medical costs and $69 billion in reduced productivity (American Diabetes Association, 2013). Those who have type 2 diabetes are unable to control insulin levels resulting in a condition called insulin resistance. In the first stages of the disease your body attempts to
Type 2 diabetes is the most common form of diabetes which affects 90% to 95% of the population. In the United States, approximately 1.7 million new cases of diabetes were identified in 2012 and the disease affects 29 million Americans or 9.3 percent of the population (Statistics About Diabetes, 2014). In 2012, the total financial burden of diabetes was estimated to be $245 billion which included $176 billion in direct medical costs and $69 billion in reduced productivity (American Diabetes Association, 2013). Those who have type 2 diabetes are unable to control insulin levels resulting in a condition called insulin resistance. In the first stages of the disease your body
“If someone has Type 2 Diabetes their pancreas may not produce enough insulin or their cells resist the effects of insulin, and in extreme cases it may be a combination of both”. (AuthorSTREAM) Currently there are about 29.1 million people in the United States that have diabetes; 8.1 million of whom may be undiagnosed and/or unaware of their condition. For adults twenty years old or older, statistics say one in every ten people suffers from diabetes; in age sixty-five and older, statistics say that figure rises to more than one in four.
A clinical study placed in the package insert for canagliflozin compared 2 different doses, (100mg and 300mg) of it to a placebo. This study was designed to determine how effective canagliflozin was at lowering blood glucose levels for Type 2 diabetic patients already on Metformin. The study evaluated 1,284 patients who took a certain dose for 26 weeks. The results revealed that canagliflozin given at a dose of 300mg by mouth once per day decreased blood glucose levels from a baseline of 7.95% by 0.94%. Canagliflozin given at a dose of 100mg by mouth once per day decreased blood glucose levels from a baseline of 7.94% by 0.79%. The canagliflozin 300mg dose also lowered fasting plasma glucose (FPG) from a baseline of 173mg/dL by 38 mg/dL. Canagliflozin 100mg lowered FPG from a baseline of 169mg/dL by 27mg/dL (p<0.001 for both doses).2
What is Diabetes? Diabetes affects approximately 6% of Americans, 17 million people, and alarmingly 5.9 million of them are unaware that they have this chronic disease. Diabetes is a disease that is classified into two central types, type 1 and type 2. The disease results in the body being incapable of producing enough insulin and also causes an inability to use the insulin that has produced. Type 1 diabetes is considered to be an autoimmune disease that has the ability to destroy the facility of the pancreas to produce insulin. Type 2 diabetes is a more complex disease that is characterized by elevated blood glucose levels which causes the body to produce but causes an inability to properly use what has been produced. Although millions of Americans suffer from this chronic disease, which can immerge in early childhood with the little-known cause of the disease, it is believed that diabetes is triggered by poor diet, exercise, obesity and inherited through genetics. Diabetes is a very manageable disease when it detected early but left untreated and managed it can possibly lead to death. A poor diet and obesity are a few of the leading causes of type 2 diabetes, which is the result of nutritional deficiencies. An individual with a body mass index of thirty or more increases their chances of developing type 2 diabetes. Currently in America, younger children have a greater risk factor of developing type 2 diabetes due to long term diets that consists of high saturated
Diabetes mellitus is most commonly known as diabetes. Diabetes is formally a Greek word that translates to, “the making of lots of urine with sugar in it or making sweet urine” Brawley. This disease is due to a metabolic dysfunction. Diabetes is caused due to the fact that insufficient insulin is being produced in the pancreas. Sometimes this disease can even be caused because the cells are not being responsive to the insulin being produced. Unfortunately diabetes is not just one single strand but it comes in Type 1, Type 2 and gestational diabetes. To begin with, diabetes is not specified to just one group age or gender it can strike anyone from any age in life. According to the distinguished, What is Diabetes?, article, in the past years the amount of diabetes cases has increased dramatically by 50 percent making it be 29 million people suffering from this disease.
Diabetes Mellitus is a disorder of too little, too much or ineffective use of insulin. The different classifications of this are know as type I diabetes or IDDM (insulin dependent or juvenile diabetes), type 2 diabetes or NIDDM (non-insulin dependent diabetes or adult on-set), and gestational diabetes mellitus. There is also pre-diabetes, which is the term used to indicate the condition of impaired glucose balance, impaired fasting, or tolerance of glucose. This is more of a risk factor for a possible future disorder of diabetes, which if caught early along with behavioral change, can be prevented.