preview

Exploratory Summary

Decent Essays

Patients and Methods This study was a part of an exploratory analysis of a sample of COPD patients evaluating the relationship between fatigue and serum biomarkers of autoimmunity. Initially we demonstrated that in patients with COPD the presence of fatigue is associated with worse health status, lung function and exercise capacity.The protocol of this clinical study was approved by the Ethics Committee of the University of Medicine and Pharmacy `Gr. T. Popa` Iași, România. Participants who were willing to participate based on signed informed consent were subsequently enrolled. Inclusion criteria for COPD patients consisted of: COPD diagnosis known for at least one year, absence of systemic corticosteroids in the therapeutic regimen during the …show more content…

This questionnaire has several subdomain scores including Vitality, Physical Functioning or Emotional Role Functioning and two component scores Physical (SF-PCS) respectively Mental (SF-MCS), the scores ranging from 0 (worst possible) to 100 (best possible) [10]. In this study, SF-36 was used to compare HRQoL in both populations and in particular, to detect the presence of the clinically significant fatigue: this is defined with scores for Vitality subdomain of 50 or less. This cut-off being validated in other autoimmune debilitating diseases such as multiple sclerosis or rheumatoid arthritis [11-13]. Health status (HS) was evaluated only in COPD patients with the disease-specific Clinical COPD Questionnaire (CCQ). This has a 10 items and three domain scores for symptoms (CCQ-S), mental status (CCQ-M)and functional status (CCQ-F), and it also has a total score (CCQ-T) [14]. Higher scores are associated with worse health

Get Access