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Operative Morbidity And Mortality On Patients With Diabetes

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Peri-operative morbidity and mortality is higher in patients with diabetes (1, 2), and they have a longer hospital stay than non-diabetic patients. There is a lot of evidence to show that poor glycaemic control before, during and after surgery increases the risk of adverse outcomes, irrespective of whether the patient is a diabetic or not. (3) Peri-operative hyperglycaemia in surgical patients is associated with increased complications following surgery, especially wound infections.(4) Prevention of hyperglycaemia reduces the risk of complications of cardiac surgery (5, 6) and also reduces morbidity and mortality in intensive care patients.(7) There is sufficient ground to assume that this holds true beyond the cardiac surgical and cardiac ICU patients, and is applicable to all patients with diabetes undergoing surgery.(8)

There is an increasing body of evidence to show that apart from control of acute blood sugar fluctuations in the peri-operative period, long- term control of blood sugar levels also plays an important role in reducing diabetic complications after surgery.

HbA1c (glycosylated haemoglobin) is an important marker of long- term glycaemic control. Glycosylation of haemoglobin is a non-enzymatic irreversible reaction between haemoglobin beta chains and glucose molecules, the extent of glycosylation being dependant on the average blood sugar levels over the preceding three months. There are many methods of quantifying the amount of HbA1c in blood, including ion

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