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Targeted Temperature Management Case Study

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For more than a decade, Targeted Temperature Management (TTM) has been the recommended treatment modality in adult comatose patients following out-of-hospital cardiac arrest (OHCA)[1] in order to improve survival and neurological outcome by minimizing brain injuries due to anoxia and reperfusion injury. Initially, cooling was recommended to 32° C-34° C[6, 7], but the enhanced effect of cooling at 33° C compared to 36° C in terms of mortality and neurological outcome could not be proven[2]. Since the most optimal cooling level is yet unknown, current (2015) Resuscitation Guidelines recommend mild hypothermia treatment regimen at the temperature range between 32° C and 36° C[3, 4]. Mild hypothermia is generally considered gentle and safe[8] although a minor subset of patients may experience side effects such as infections, coagulation and electrolyte disturbances and potentially life-threatening arrhythmias during post-cardiac arrest care[5]. …show more content…

The lowest safe cooling threshold in order to avoid the development of malignant ventricular arrhythmias is still not defined. The clinical ECG findings of hypothermia include reversible and temperature-dependent abnormalities: morphology (Osborn waves), rhythm (bradycardia, premature atrial and/or ventricular beats, atrial fibrillation, VT/VF), time (prolonged PR, QRS, and QT intervals ) and conduction (AV-block)[14, 15]. The temperature decrease results in alterations of the autonomic sympathetic response[11] and in impaired conduction velocity of the electrical signals through the

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