Diabetes is a heterogeneous group of metabolic diseases characterised by high levels of blood glucose (hyperglycaemia) due to defects in the β cell function in the pancreas which is impacting the insulin secretion or insulin action, resulting in the inability to self-regulate the levels of blood glucose in the body (Stumvoll et al.,2005). Short term symptoms of hyperglycaemia include: polyuria , polydipsia, blurred vision, however the chronic effects of hyperglycaemia are associated with long term organ dysfunction and damage, especially the blood vessels, retina in the eye, kidneys and heart (Uazman et al., 2014). Diabetes has become a world-wide concern due to its high prevalence in the world (in 2015, 415 million of people were estimated …show more content…
The first type is Type-1 diabetes mellitus (T1DM), which accounts for around 5 – 10 % of all the patients diagnosed with diabetes and it is an auto-immune disease that is characterised by the progressive destruction of β cells which eventually leads to nearly complete insulin deficiency. T1DM is also called insulin dependent diabetes or juvenile-onset diabetes, being more often seen in children or young populations (Imkampe and Gulliford, 2011). 80 – 90 % of the population that is being diagnosed with T1DM are noted to also have some of the following anti-bodies raised: glutamic acid decarboxylase, tyrosine phosphatases and insulin. They also tend to be more susceptible to develop other types of diseases such as: Addison’s disease, coeliac disease, myasthenia gravis, autoimmune hepatitis (American Diabetes Association, 2014) and they usually are of normal or even low weight. To be noted that obesity does not exclude the diagnosis of …show more content…
Most patients that are diagnosed with T2DM are noted to be either overweight or obese. High levels of body fat percentage, high body mass index (BMI), lack of physical activity, hypertension and some ethnicities (Hispanic, south Asian and Middle Easterns) are important risk factors for this type of disease. There are also some genetic markers risk factors and there is often a history of the disease in the family, however these factors are not used in routine diagnosis practice (Solis- Herrera et al., 2014). In this more prevalent type of diabetes, the cause for hyperglycaemia (high level of blood glucose) is considered to be a combination of both an increased resistance to the action of insulin and an inadequate insulin secretion response. At the time of diagnosis almost all patients have some degree of impaired insulin secretion (Defronzo, 2009). It depends on the degree of hyperglycaemia, however, after some level it can cause functional and pathological changes to some tissues but without any symptoms. For this reason, the dysfunction in the β cells can be present for a long period of time, before it can be diagnosed. However, it is still possible to be diagnosed by measuring blood glucose levels of individuals at a fasting state, during an oral glucose tolerance test (OGTT) or via measurements of HbA1c in
Diabetes is a growing concern and health challenge for the American people (b). Diabetes is a condition in which the body cannot react to insulin appropriately or either cannot produce insulin efficiently (w). “Without a properly functioning insulin signaling system, blood glucose levels become elevated and other metabolic abnormalities occur, leading to the development of serious, disabling complications” (w). There are numerous forms of diabetes amongst the nation, however, there are three main forms of diabetes. Most people have heard of type one diabetes, type two diabetes, and gestational diabetes because they are common. Type two diabetes deals with a resistance to insulin, while
Diabetes Mellitus (DM) or Type 2 Diabetes is seen as a metabolic disease that is categorized by abnormally high blood glucose or hyperglycemia. Diabetes Mellitus is also formerly known as noninsulin-dependent diabetes mellitus and is the most common form of diabetes that is seen. Insulin is a hormone that is supplied to the body that allows us to efficiently use glucose as fuel. When carbohydrates are broken down into sugars in the stomach glucose enters the blood circulation simulating the pancreas to release insulin in an appropriate amount to become used for energy. With diabetes mellitus the body does not properly make use of the insulin supplied for the body. This causes the pancreas to produced an extra amount if insulin which the body cannot keep up with, causing an imbalance to the blood glucose levels (American Diabetes Association, 2015). In the united states diabetes affects almost 29.1 million people, while the another 86 million people have pre-diabetes but do not know. It is also known as the 7th leading cause of death in the country in the recent years (MedicineNet.com, 2016). For a patient suffering from a chronic form of diabetes mellitus understanding how these mechanisms lead to the condition can be used as preventative measures. Potential consequences as well as the causes and clinical manifestations will ensure a better knowledge on the issue to monitor the condition.
Diabetes is a very common disease around the world. If you treat it properly it will not create any future problems and you can live a healthy life. Diabetes has to do with a lack of insulin in the body which causes high blood sugar. There are several forms of diabetes, but type 1 forms when you body suddenly is unable to produce the insulin your body needs to function. Unlike other types, signs of type 1 develop very quickly leading to the disease forming within days or weeks.
Type 1 diabetes is a disease where the pancreas no longer produces insulin for the body function properly and survive. When your body is no longer producing insulin, you will need a way to provide your body with insulin to function properly and to survive. Type 1 Diabetes in children is commonly known as juvenile diabetes or insulin-dependent diabetes.
Diabetes one, and two revolve around the hormone insulin. Insulin is produced by the pancreas and its job is to help the cells in the body absorb glucose from the blood. Once the glucose is absorbed it signals beta cells from the pancreas to secrete insulin. Insulin enables glucose to enter cells of the liver and muscle. After the glucose has entered the cells, hormones that include insulin, decided if the glucose will be used as energy, or stored as glycogen for the future. The stored glycogen is important because if you haven’t eaten and your blood sugar is low, the body can take from the stored glycogen and use it as a source of energy.
Diabetes is a long-term metabolic condition characterized by high blood sugar levels. There are three major categories of the disease, type 1 diabetes occurs when the body produces minimal or no insulin, type 2 diabetes is when the body produces either little insulin or the cells are unable to respond to insulin, gestational diabetes mainly occurs during pregnancy. Non-Insulin Dependent Diabetes Mellitus, which is, type 2 diabetes is the most prevalent. The major complication that is caused by Type 2 diabetes is unremitting hyperglycemia, which leads to numerous changes in the body. There are several alterations in cellular, cardiovascular, and nervous functioning, which contribute to complications such as neuropathies and heart
Diabetes is a metabolic disorder that can affect multiple system of the body that range from the urinary system to the nervous system. The effects of such a diseases can be very detrimental on an individual life. Individuals that develop such a disease require tons of medications, exercise and a very drastic change in diet that might eliminate certain foods. Although there are no cures for such a disease different types of medication can be used ranging from pill form to insulin injections. Diabetes also comes with many negative symptoms that drain the bodies physically and mentally. There are 3 types of diabetes that are very dissimilar when it comes to cause, treatment and symptoms. Awareness for such a disease can be a very important aspect that must be taken in to consideration to avoid the development of this disorder and in this
Diabetes is typically classified as either type 1 or 2, but there actually many other types of diabetes (e.g. gestational, drug-induced, infection-induced, or disease-induced, etc.). However. These represent a very much small minority of the total number of cases of diabetes and they will not be discussed here.
Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction, and failure of various organs especially the eyes, kidneys, nerves, heart, and blood vessels. Type 1 DM once known as juvenile diabetes or Insulin dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin. Although type 1 diabetes can develop at any age, it typically appears during childhood or adolescence (1).
So what is diabetes? Diabetes or Diabetes mellitus is a group of metabolic diseases in which there are high blood sugar levels over prolonged period. There are two types of diabetes and for the purpose of this paper I will be discussing only the Type 1 Diabetes. Type 1 Diabetes results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. In other words with type 1 diabetes, the body’s immune system attacks part of its own pancreas. Scientists, however, are not sure as to why this occurs. But
According to Meng, Chunyan, Xiaosheng, Xiangren (2018), diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas or by the ineffectiveness of the insulin produced. The first WHO Global report on diabetes suggested that the most-to-date number of adults living with diabetes is 422 million, which has almost quadrupled since 1980. This dramatic rise is largely due to the prevalence of type 2 diabetes and the factors driving it include overweight and obesity (para. 1).
I chose to do diabetes for my rough draft. There are two types of diabetes, type one and type two. Type one is known as juvenile. Type one diabetes happens when your immune system destroys beta cells in your pancreas.
Diabetes Mellitus (DM) is a serious public health problem in the world that has an adverse effect on the quality of life of several people (Al-Sarayra & Khalidi, 2012; Azinge, 2013)1. It is highlighted for morbidity and mortality (Khattab, Khader, Al-Khawaldeh, & Ajlouni, 2010; Sagar, 2011)2. World Health Organization (WHO) defines DM as metabolic disorder characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism that results from disturbances in insulin secretion, insulin action, or both. Diabetes is associated with reduced life expectancy; the significant morbidity associated with diabetes arises from micro vascular complications, increased risk of macro vascular complications (like ischemic heart disease, stroke, and peripheral vascular disease), and diminished quality of life3 (WHO, 1999).
Diabetes mellitus is a group of metabolic diseases characterised by hyperglycaemia (elevated blood sugar level) affecting the metabolism of carbohydrates, proteins and fats, resulting from the inability of the body to secrete and/or use insulin (American Diabetes Association (ADA), 2005; World Health Organisation (WHO), 2016). Patients with type-1 Diabetes Mellitus (T1DM) requires insulin for survival as the cell-mediated destruction of the β-cells of the pancreas eventually lead to a lack of insulin secretion (ADA, 2005; WHO, 2016) . Conversely, type-2 Diabetes Mellitus patients have insulin resistance (ADA, 2005) wherein their bodies cannot use the little insulin that it produces (WHO, 2016).
Diabetes Mellitus is “a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. It is a disease which is caused by the insufficient insulin secretion or decrease in the peripheral effects of insulin. It is a serious problem in terms of morbidity and mortality. The hyperglycemia is associated with long term damage, dysfunction and failure of various organs especially the eyes, kidneys, nerves, heart and blood vessels. It’s associated with many complications which includes blindness of the eyes and amputations of the extremities. It is also associated with neuropathy, retinopathy, and cardiovascular diseases which lead to mortalities.