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-. Succinate dehydrogenase contains iron-sulfur centers in which irons are complexed with cysteine residues. You mutate those cysteines to serines, which is a conservative mutation so it will not mess up the structure, but iron is not complexed effectively. a) What effect will this have on electron transport? Which complex will be affected? yes, complex 3, Complex 4, b) How many protons will be pumped per glucose molecule now assuming everything else continues as normal? How many total ATPs will you make per glucose for the entire glucose catabolism (again assuming everything else, including citric acid cycle continues as normal)? Only 4 protons pumped from #1 and 2H+ from #4 Glycolysis=2 ATP CAC = 2 ATP ETC=Ø 4 ATP c) Would everything actually continue as normal? What do you think would actually happen in cells? How many total ATPs would you make per glucose? 4 ATP, No, very low energy output slow growth + replication d) If the FADH₂ is subsequently oxidized by a matrix NAD* to regenerate it, how many ATP molecules will you now make from 1 glucose?

-. Succinate dehydrogenase contains iron-sulfur centers in which irons are complexed with cysteine residues. You mutate those cysteines to serines, which is a conservative mutation so it will not mess up the structure, but iron is not complexed effectively. a) What effect will this have on electron transport? Which complex will be affected? yes, complex 3, Complex 4, b) How many protons will be pumped per glucose molecule now assuming everything else continues as normal? How many total ATPs will you make per glucose for the entire glucose catabolism (again assuming everything else, including citric acid cycle continues as normal)? Only 4 protons pumped from #1 and 2H+ from #4 Glycolysis=2 ATP CAC = 2 ATP ETC=Ø 4 ATP c) Would everything actually continue as normal? What do you think would actually happen in cells? How many total ATPs would you make per glucose? 4 ATP, No, very low energy output slow growth + replication d) If the FADH₂ is subsequently oxidized by a matrix NAD* to regenerate it, how many ATP molecules will you now make from 1 glucose?

Biochemistry
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 13P
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Please check my work and make corrections for parts A, B, and C and explain the answer for part D. Thank you!
been removed by Kinase anyway. They only thing that would change is not needing Kinase in that step. 4. Succinate dehydrogenase contains iron-sulfur centers in which irons are complexed with cysteine residues. You mutate those cysteines to serines, which is a conservative mutation so it will not mess up the structure, but iron is not complexed effectively. a) What effect will this have on electron transport? Which complex will be affected? Yes, complex 3, Complex 4, b) How many protons will be pumped per glucose molecule now assuming everything else continues as normal? How many total ATPs will you make per glucose for the entire glucose catabolism (again assuming everything else, including citric acid cycle continues as normal)? Only 4 protons pumped from #1 and 2H+ from #4 4 ATP Glycolysis=2 ATP CAC = 2 ATP ETC-0 c) Would everything actually continue as normal? What do you think would actually happen in cells? How many total ATPs would you make per glucose? 4 ATP, No, very low energy Output slow growth + replication d) If the FADH₂ is subsequently oxidized by a matrix NAD* to regenerate it, how many ATP molecules will you now make from 1 glucose?
Transcribed Image Text:been removed by Kinase anyway. They only thing that would change is not needing Kinase in that step. 4. Succinate dehydrogenase contains iron-sulfur centers in which irons are complexed with cysteine residues. You mutate those cysteines to serines, which is a conservative mutation so it will not mess up the structure, but iron is not complexed effectively. a) What effect will this have on electron transport? Which complex will be affected? Yes, complex 3, Complex 4, b) How many protons will be pumped per glucose molecule now assuming everything else continues as normal? How many total ATPs will you make per glucose for the entire glucose catabolism (again assuming everything else, including citric acid cycle continues as normal)? Only 4 protons pumped from #1 and 2H+ from #4 4 ATP Glycolysis=2 ATP CAC = 2 ATP ETC-0 c) Would everything actually continue as normal? What do you think would actually happen in cells? How many total ATPs would you make per glucose? 4 ATP, No, very low energy Output slow growth + replication d) If the FADH₂ is subsequently oxidized by a matrix NAD* to regenerate it, how many ATP molecules will you now make from 1 glucose?
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