133.8.3.8You are a genetic counselor and a couple has come to you for advice. They have a family history ofcancer and are concerned that their unborn third child will also get cancer. They provide you withthe following pedigrees for two different traits relating to defects in the enzymes separase andtopoisomerase:A.SeparasedefectB.Topoisomerasedefect421.4.6.6.9.6.5.5.111213111214151415These two pedigrees represent the same family. Genetic testing shows that individual 4 has onlynonmutant alleles of both genes and individual 12 has only mutant alleles of both genes. Individuals6, 8, 9, 12, and 14 have cancer. The couple just recently learned that their daughter (individual 14)has cancer and has both mutations. In this lab activity, you will use Punnett squares to determinethe probability that the couple's third unborn child will also inherit both mutations and be at riskfor developing cancer..Using Punnett squares, determine the phenotypes of offspring that the following parents couldproduce. For some situations, there could be more than one genotype for at least one of the parents.In these cases, be sure to include Punnett squares for all possibilities, and give the probablilty thattheir third unborn child may be at risk for developing cancer.1. An autosomal recessive trait with an unaffected mother and an affected father.2. An autosomal dominant trait with an affected mother and an unaffected father.3. An X-linked recessive trait with an unaffected mother and an affected father.4. An X-linked dominant trait with an unaffected mother and an affected father.

.Using Punnett squares, determine the phenotypes of offspring that th produce. For some situations, there could be more than one genotype for at least one of the parents. In these cases, be sure to include Punnett squares for all possibilities, and give the probablilty that their third unborn child may be at risk for developing cancer. ng par 1. An autosomal recessive trait with an unaffected mother and an affected father. 2. An autosomal dominant trait with an affected mother and an unaffected father. 3. An X-linked recessive trait with an unaffected mother and an affected father.

.Using Punnett squares, determine the phenotypes of offspring that th produce. For some situations, there could be more than one genotype for at least one of the parents. In these cases, be sure to include Punnett squares for all possibilities, and give the probablilty that their third unborn child may be at risk for developing cancer. ng par 1. An autosomal recessive trait with an unaffected mother and an affected father. 2. An autosomal dominant trait with an affected mother and an unaffected father. 3. An X-linked recessive trait with an unaffected mother and an affected father.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 14QP

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1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). a) Hypothetically, what specific type of VECTOR will you use to perform your gene therapy? Please select from the following list of potential vectors: disabled retrovirus, adenovirus, adeno-associated virus (AAV), or herpes simplex virus (HSV), then give two reasons why this specific vector is the most appropriate for your gene therapy. Please explain why you were able to rule out the other potential…
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