4 0.1a) Account for the ditterences observed in the pKa values of Ihe tollowing saturated heterocycles.ČH,pKa10.4-2.1-4.5b) Explain why furan undergoes electrophiäic substitution reactions about 10" times lastler ihanbenzene.a) Propose a simple synthests for the compound below trom suitable reagents.:CO,Meco,Me

Answered: Image /qna-images/answer/6175d415-14ef-427b-b4a6-ceca903fc462.jpg

0.1 a) Account for the differences observed in the pka vatues of the following saturated heterocycles. CH, pKa 10.4 -2.1 4.5 b) Explain why furan undergoes elecrophäic substitution reactions about 10" times lasler ihan benzene.

0.1 a) Account for the differences observed in the pka vatues of the following saturated heterocycles. CH, pKa 10.4 -2.1 4.5 b) Explain why furan undergoes elecrophäic substitution reactions about 10" times lasler ihan benzene.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Related questions

Q: What is one property of solids that makes them fundamentally different from liquids? I hat is one pr...

A: Property of definite volume and shape at given temperature make solids fundamentally different from ...

Q: Suppose the reaction between nitric oxide and oxygen proceeds by the following mechanism: step eleme...

Q: Use the dropdown menus in the sentence below to indicate if Ha and Hb within the structure are homot...

A: In a given structure relation between two hydrogen atoms can be determined by replacing these two hy...

Q: 25. Why is NAD+ a good oxidizing agent? a. It fits into the enzyme active site for isocitrate oxidat...

Q: In sigma MO the electron density is concentrated around a line between the two nuclei of the bonding...

A: Molecular orbital can be defined as the orbital formed by addition or subtraction of atomic orbitals...

Q: 1. Comment on the differences in measurements obtained on the same objects using the meter stick, ru...

A: A question based on general chemistry that is to be accomplished.

Q: When the potential energy is zero the two atoms are/have O far apart O started to overlap sufficient...

A: Please find your solution below : The potential energy of the atoms in terms of of the their positio...

Q: different

A: Proteins are polymers of amino acids.Their three dimensional structure depends mainly on the sequenc...

Q: Question 9 What is the most appropriate time to use a safety shower? 1) You spilled 400 milliliters ...

A: The most appropriate time to use a safety shower is when you spilled 400 millilitres of concentrated...

Q: 4.33g sample of an unknown salt (MM=116.83g/mol) is dissolved in 150.00g water coffee cup calorimete...

Q: Use the dropdown menus in the sentence below to indicate if Ha and Hb within the structure are homot...

A: Relationship between Ha & Hb = ? Signal for Ha & Hb = ?

Q: b) Crystallization proceeds through a series of interdependent mechanisms, where e step is uniquely ...

A: Crystallization mechanism consists of six steps : 1.order of nucleation 2.Growth 3.phase seperat...

Q: Given below are two elementary steps for a reaction mechanism. Choose the correct form of the Kc for...

A: Add the two elementary steps for reaction mechanism to find the net reaction and then write the expr...

Q: How much heat is released by burning 32g of CH4? CH4(g) + 2O2 → CO2(g) + 2H2O(l) ΔH=-891kJ

A: Given, CH4(g) + 2O2 → CO2(g) + 2H2O(l) ΔH= -891kJ Note: (-) negative sign indicate the release of ...

Q: What is matter

A: Define the matter ?

Q: What is the enthalpy of formation (AH°;) of NaHCO3(s) from its constituent elements?

Q: A chemical engineer is studying the following reaction: 2 H,S(g)+302(g) → 2 SO,(g)+2H,0(9) At the te...

Q: SH CH3CH2CH2CH2

Q: . CH3CH2F B. CH3CH2CH21 - CHoCHoOH

A: The M+2 peak in a mass spectrum arises from the presence of chlorine or bromine atoms i.e a halogen ...

Q: Select the IUPAC name for the following structure: CH3 CH-CH, CH,CH, CH,-CH-CH-CH,-CH-CH, CH,-C-CH, ...

A: The compound given is,

Q: In the "Torch the Money" demonstration, a $5 bill is wrapped around a copper pipe and then placed ov...

A: As the 5 $ bill was wrapped around copper pipe, and placed in candle flame for 5 seconds. The hear s...

Q: A closed vessel of volume 2.1 L contains a mixture of neon and fluorine gas. The total pressure of t...

A: Given, Volume of the closed vessel = 2.1 L Total pressure = 3.8 atm at 0°C The mixture is heated ...

Q: • Part A Given the following reaction at 298 K: 2 H2S(g) + SO2(9) → Ss (s) + 2 H2O(9) Calculate A,G ...

A: Under standard condition ΔGo=-102 kJ/mol Under non standard condition ΔG=-100 kJ/mol

Q: С. B. :01 :CI;

Q: 16. Which of the intermediates shown below is generated during the following reaction? H,SO4 OH OCH2...

Q: Step 3: add curved arrows. Step 1: add curved arrows. Step 2: add curved arrows. Select Draw Rings M...

Q: AIs questioL Tlas lmuiti a Complete the right side of the following molecular equation. Assume all s...

Q: The concentration and absorbance data below were collected for compound X. A sample of compound X of...

Q: The square planar molecule XeF4, has Dan symmetry. Consider the dzy and d,2_y2 0orbitals of the cent...

Q: What is the enthalpy of the reaction P406 (s) + 202(g)→P4010(s), given a) P4(s) + 302(g)→P406 AH = -...

Q: The following line angle drawings have all lone pairs shown. Add formal charges on specific atoms wh...

A: Here lone pairs are shown on each atoms, we have to draw the formal charge. And the overall molecule...

Q: Select the pair of compounds that CANNOT be distinguished by their IR spectr. O A. CHCI3 and CCI4 O ...

A: For any molecules to be IR active they should be having dynamic dipole moment i.e. the change in dip...

Q: Consider the reaction 2NOBR ) + 2NO (3) + Br2 (s) A container is initially filled with only NOBr at ...

A: Kp is the ratio of the equilibrium partial pressure of product over equilibrium partial pressure of ...

Q: Carbon disulfide and oxygen react to form carbon dioxide and sulfur dioxide, like this: cs,(e)+30,(2...

A: The given reaction: CS2(g) + 3O2(g) --------> CO2(g) + SO2(g) K = (Pco2)*(Pso2)/(Pcs2)*(Po2)3...

Q: 15. What is the product obtained when a carboxylic acid is reduced? b. a primary alcohol a. an alken...

A: Note : Since you have posted multiple questions, we are entitled to answer the first only. Please re...

Q: Gas Chromatography (GC) is one of the useful techniques in analytical chemistry. Give two important ...

A: It is one of the most convenient technique for the analysis and separation purposes of molecules in ...

Q: A 0.492 M solution of a weak base has a pH of 10.59. What is the base hydrolysis constant, Ko. for t...

Q: Question 9 What is the most appropriate time to use a safety shower? 1) You spilled 400 milliliters ...

A: The correct option is:

Q: Consider the following thermochemical reaction for kerosene: 2C12H16 (l) + 37O2 (g) → 24CO2 (g) + 2...

Q: Quntien 1 Using pka valves, ladicate the position of equilibeiam for eencticns aband e.

A: Pka is -log(Ka); Higher Ka,lower Pka. Ka will high when dissociation is easy.

Q: 3. At 298 K, the EMF of the cell shown below is +0.84 V. Pt(s) Fe"(aq, a = 1), Fe³*(aq, a = 1)|| Ce*...

Q: Curved arrows are used to illustrate the flow of electrons. Follow the curved arrows and draw the st...

A: Concept: Bromination of Alkene: The reaction mechanism for an alkene bromination follows two steps....

Q: Based on Valence Bond Theory, what happens when two atomic orbitals overlap? * O A single molecular ...

A: The 4th option is correct that is : The two atomic orbitals share a common region in space. Reason :...

Q: Consider this reaction: CICH,CH,CI (g) → CH,CHCI (g)+HC1 (g) At a certain temperature it obeys this ...

Q: Consider the following reaction where Ke = 1.20x102 at 500 K: PCI, (9) PCI, (9) + Cl2 (9) A reaction...

Q: 5. Look at the graph about carbon dioxide levels over 50 years. Answer the questions. 400 390 380 37...

Q: In mass spectrometry, the molecular ion peak occurs at O A. the largest m/z value. O B. the smallest...

A: In mass spectrometry we use high energy electron bombardment on the sample to ionized that sample an...

Q: Write the IUPAC names of the following organic compounds if given the structure. Draw the organic co...

Q: Methane and chlorine react to form chloroform and hydrogen chloride, like this: CH,(9)+3Cl,(9) -→ CH...

A: Le Chatelier's principle: This principle is used to predict the effect of a change in conditions on ...

Q: Alkylation of acetylide ions with alkylhalides or i tosylates

A: alkylation

Question

0.1
a) Account for the ditterences observed in the pKa values of Ihe tollowing saturated heterocycles.
ČH,
pKa
10.4
-2.1
-4.5
b) Explain why furan undergoes electrophiäic substitution reactions about 10" times lastler ihan
benzene.
a) Propose a simple synthests for the compound below trom suitable reagents.:
CO,Me
co,Me

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step by step

Solved in 2 steps with 2 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

1) 1544565- NH₂ 2) CI of & 7) 8) reagents used: FeCl3/Cl₂ HNO3/H₂SO4 MeCI/AICI3 ACCI/Et₂N SO3/H₂SO4 Pd/C, H₂ NaOH H₂SO4/heat ACCI= CI [Choose ]
Which synthetic route(s) would complete the reaction shown? Br || ||| I and II O I and III ? HO OH + enantiomer Synthesis I: 1. NaCCCH3; 2. Na/NH3(I) ;3. OsO4; 4. NaHSO3, H₂O Synthesis II: 2. NaCCCH3; 2. H2, Lindlar's catalyst; 3. MCPBA; 4. aq. H₂SO4 Synthesis III: 1. NaCCCH3; 2. H₂, Pt; 3. MCPBA; 4. aq. H₂SO4
What reagents are appropriate to carry out the conversion shown? - OH LOM 1. mCPBA; 2. CH3MgBr; 3. H₂O O 1. CH3MgBr; 2. H₂O O 1. mCPBA; 2. H₂O O mCPBA + enantiomer
20:24 1 : 10. Draw the full cleavage of 2-ethoxypropane by HCI scheme on your paper, and then draw in the curved arrows for each step of the mechanism. HICI co OⓇ ← H₂O 11. What reagent can be used to convert 2-methylbutan-1-ol into 2-methylbutanal? A) Bleach B) LIAIH4 C) DMSO, (COCI)2, TEA D) Na₂Cr₂O7, H₂SO4 E) 03 12. Fill in the box with the major organic product of the first step of the reaction shown? H-Cl Send a chat O
32. (14) Predict the major organic product of the following reactions or provide the reagents needed to complete each transformation. Clearly show stereochemistry where appropriate. (a-b) (c-d) (e-f) (g-h) KOH heat LDA heat CH3 1. Br₂, light 2. CH3O+K, heat CH3 NaBH4 CH3OH Br S Na+ CN H₂O cold KMnO4 1. CH3MgBr 2. H₂O, H+
1. (cont.) CH3 Cl- -CF3 CH;NH2 (i) H ОН ČH,CH3 CH, 1. PBr,/pyridine (j) ОН 2. NaOH/DMSO 2. Using the given starting material and any necessary reagents indicate how the following syntheses can be carried out. ОН CH;CH,CHCH3 CH,CH,CH,COH OH CH;CH,CHCH3 CH;CH,C=CH .OTS OCH3 CH3 CH3 ОН 3. Propose a mechanism that accounts for the formation of the product shown during the following observed reaction. Be sure to show all intermediates. ОН H+
32. (14) Predict the major organic product of the following reactions or provide the reagents needed to complete each transformation. Clearly show stereochemistry where appropriate. (a-b) (c-d) (e-f) (g-h) (i-j) (m-n) KOH heat NBS hv 1. Br₂, light 2. CH3O+K, heat LDA heat CH3 NaBH4 CH3OH CH3 CH₂l2, Cu Zn H₂O „H Br Na+ CN H₂O cold KMnO4 1. CH3MgBr 2. H₂O, H+ CH3OH, heat CH3S- +Na acetone mCPBA
19). What is the major organic product of the following reactions? LBCH COOH 2. Pyridine ? (-HB) (4) D C " & & & & &
: For the following reaition ) choo se the organic products that uill be formed and then 2) indicate whether the produts was / were formed via an SNI ,Sw2, E1, E2 mechonism. For elimination realtions, only consider the major alkene. Q1: OH H2 S04 O SO,H possible products : a. d. mechanisms : Q2: Br possible produuts: emultiple) Br a. d. C. mechanisms : LAN 十。 Q3. posible produts : Aloin loax c. ef Jloe s I.k a . mechani sms Q4. Br CH3 NadCH3 CH3 CH3 0H C6HS CH2CH3 ocH3 ocHs C6HS CH3 CH2CH3 H- CH3 posible prodacte R CHs CH3 CH3 CH2 CHs cH3 G. b. d. C. mechanism
Determine the mechanism of nucleophilic substitution of each reaction and draw the products, including stereochemistr CH₂CH3 CI Br + CN d. + CH3COOH a. acetone + -OCH3 e. DMF f. b. C. ||||| a ||||| Br H Br CH2CH2CH3 + CH3OH DMSO H CH3 CI Br + OCH₂CH3 + CH3CH₂OH
The macrocyclic ester L can be prepared by a ring closing metathesis (RCM)-alkene reduction strategy as outlined below. Answer sections (i) to (iii) related to this process. Joa M N OH O CO₂H (i) Draw the structure of a ruthenium-based catalyst commonly used for RCM and provide a simplified reaction mechanism for the RCM of diene M. (ii) Disconnect M and show the resultant synthons which correspond to alcohol N and carboxylic acid O. (iii) Based on your answer to section (ii), discuss the forward reaction to form M mentioning any additional reagents and explaining their role.
Which reaction below give a par of diastereomers and Why?