1 0.9 Unfolded 0.8 Molten 0.7 globule Native 0.6 0.5 0.4 0.1 Denaturant concentration 0.2 0.3 Fig. 5 A theoretical phase diagram for a model protein. Temperature

Chemistry: The Molecular Science
5th Edition
ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter10: Fuels, Organic Chemicals, And Polymers
Section: Chapter Questions
Problem 119QRT
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In a theoretical study of protein-like polymers, the phase diagram shown was obtained. It shows three structural regions: the native form, the unfolded form, and a 'molten globule' form. (a) Is the molten-globule form ever stable when the denaturant concentration is below 0. 1? (b) Describe what happens to the polymer as the native form is heated in the presence of denaturant at concentration 0. 15.

1
0.9
Unfolded
0.8
Molten
0.7
globule
Native
0.6
0.5
0.4
0.1
Denaturant concentration
0.2
0.3
Fig. 5 A theoretical phase diagram for a model protein.
Temperature
Transcribed Image Text:1 0.9 Unfolded 0.8 Molten 0.7 globule Native 0.6 0.5 0.4 0.1 Denaturant concentration 0.2 0.3 Fig. 5 A theoretical phase diagram for a model protein. Temperature
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