1. Both parents have one dominant allele and one recessive allele. This means that they are heterozygous for that particular gene. How many percent chance of them producing a child with Huntington's disease?
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- 1. Mary and Joe are both healthy individuals. Joe has a mother who suffered from cystic fibrosis, an autosomal recessive disorder. Mary has been genetically tested in order to find out if she has the allele responsible for this disease and her tests came out positive. They are planning on having two children together in the near future. What is the probability that she and Joe will have either 2 boys who have the disorder, OR that they have one boy who has the disorder and one boy who does not? (in other words, what is the probability that any of these two outcomes takes place? a) 1/8 b) 1/16 c) 3/32 d) 1/64 e) 9/64Part 1 - High School Blues Evan and Alexia had been happily married for seven years and had a delightful five-year-old son named Ryan. One day, while going through his old high school biology textbook, Evan stumbled on some troubling information. In the section on the genetics of eye color, he read that two blue-eyed parents cannot produce a brown-eyed child. This was disturbing to him because both he and Alexia had blue eyes, but Ryan had brown eyes. He and Alexia were very much in love and Evan didn't believe his wife had been unfaithful. Puzzled, he questioned his wife, who confirmed she had been faithful to him. Evan had known Alexia long enough to recognize when she was lying and detected nothing but honesty in her response. What is going on?3) The ability to curl ones’ tongue up on the sides (T) is dominant to not being able to roll your tongue (t). a. A woman who can roll her tongue marries a man who cannot. The first child has the same phenotype as the father, what are the genotypes of the mother, father, and this child? b. What is the probability that the second child won’t be able to roll it’s tongue?
- 5. Brown eyes are dominant over blue. This is NOT a sex-linked trait. If a blue-eyed colorblind woman marries a normal visioned man who is homozygous for brown eye color, what kind of children might they expect with respect to these two traits? If one of the sons in turn marries a heterozygous brown-eyed, normal visioned woman, not a carrier, what kinds of children might they expect? A normal woman who is a carrier for colorblindness marries a normal man. What types of offspring would you expect? 6. 100% Give Feedt5. A female child, Della, has the autosomal dominant condition of polydactyly. Della's mother has the normal number of fingers and toes like her parents and brother (Della's maternal grandparents and uncle). Della's father has six fingers on each hand and so did two of his three sisters and his mother (Della's paternal aunt and grandmother). Della has a younger brother who has the normal number of fingers and toes. Give the genotype of each parent and each child. Della's Mother Della's Father Della Della's Brother 5. Draw a pedigree demonstrating polydactyly in the family above. 716. Huntington's chorea is a dominant lethal in humans. The disease does not appear until later in life, so that afflicted individuals may already have produced children. What are the F1 genotypic and phenotypic ratios of parents who are homozygous dominant and heterozygous?
- 6 Huntington's disease causes damage to the nervous system. It is an inherited condition caused by a dominant allele (H). Only individuals who are homozygous for the recessive allele (h) are protected from the disease. The diagram shows the inheritance of Huntington's disease in a family. A F G H K M N Male Female Male with Female with Huntington's disease Huntington's disease (a) Complete the table to show how many people in the diagram fit each description. The first one has been done for you. Number of people who fit the description Description male 7 female with Huntington's disease homozygous recessive heterozygous homozygous dominant1. If a man, dominant homozygote for tongue rolling, is expecting a child with a woman that is heterozygotic for the trait – what is the probability for their firstborn to be a daughter being dominant homozygotic for tongue rolling? 2. A color-blind female is expecting with a color seeing male – what is the probability of a male child to see color? 3. In Sweden 1/500 are born with an autosomal recessive disorder called thalassemia. What is the carrier frequency within the population?3. STATEMENT: Color-blindness is due to a sex-linked recessive gene. A colorblind man marries a normal-visioned woman and they have a colorblind daughter. a) What is the genotype for the man, woman and the daughter? b) The couple decides to have another child, what is the probability their child will be: i. Colorblind? ii. Have a daughter that has normal vision, no colorblindness? They know that they're having a son because they saw the sonogram with a little noticeable Schmeckle (Oscar Meyer weiner). iii.
- 8. Huntington’s disease is a degenerative disease of the nervous system that strikes in middle age. The allele that causes the disease (H) is dominant to the allele that results in the normal condition (h). Answer the following questions about the inheritance of this disease. A. What is the genotype of a man who is normal but whose father had Huntington’s disease? B. What is the genotype of a woman who has Huntington’s disease if both of her parents had Huntington’s disease? C. If a man who is heterozygous for Huntington’s disease marries a woman who is normal, what would you expect for the genotypes and phenotypes of their children? D. If a normal man marries a woman who is homozygous for Huntington’s disease, what do you expect for the genotypes and phenotypes of their children?1. If one parent is homozygous dominant for a trait, that parent's genotype might be GG. If the other parent is homozygous recessive for the same trait, that parent's genotype would be gg. What are the possible genotypes of their offspring? b. How many different phenotypes might we possibly see in their offspring? 2. If a male is homozygous dominant for a trait, that parent's genotype might be DD. If the female is heterozygous for the same trait, her genotype would be Dd. a. How many genetically different sperm can the male produce? b. Using a Punnett square, determine the expected genotypic ratios of their offspring. What are the expected phenotypic ratios? 3. In garden peas, the gene for red flowers (R) is dominant over the gene for white flowers (r). If pollen (cells containing sperm nuclei) from the anther (male reproductive organ) of a homozygous red-flowered plant is added to the pistil (female reproductive organ containing the egg) of a white- flowered plant: a. c. What would be…1. Muscular dystrophy is an x linked recessive disorder. If two of the four offsprings have muscular dystrophy and the other two are normal, predict the genotype of the parents. The offsprins are all boys and the parents appear normal. 2. At age 50, the girl is bald and the boy is not bald. They are twins. What is the genotype of the girl? Predict the genotype of the parents of the twins.