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1. Suppose an enzyme only shows activity when the side chain -COOH group of a glutamic acid in the active site is protonated. It is known that the pKa of the side chain -COOH group is 4.07. a) Is the enzyme more active at pH 2.4 or 5.7? Explain. b) What percentage of the enzymes is active at pH = 6.5? Explain. c) At what pH will the enzyme show 78% of maximal activity?

1. Suppose an enzyme only shows activity when the side chain -COOH group of a glutamic acid in the active site is protonated. It is known that the pKa of the side chain -COOH group is 4.07. a) Is the enzyme more active at pH 2.4 or 5.7? Explain. b) What percentage of the enzymes is active at pH = 6.5? Explain. c) At what pH will the enzyme show 78% of maximal activity?

Chemistry for Today: General, Organic, and Biochemistry
Chemistry for Today: General, Organic, and Biochemistry
9th Edition
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Chapter20: Enzymes
Section: Chapter Questions
Problem 20.51E
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1. Suppose an enzyme only shows activity when the side chain -COOH group of a glutamic acid in the active site is protonated. It is known that the pKa of the side chain -COOH group is 4.07. a) Is the enzyme more active at pH 2.4 or 5.7? Explain. b) What percentage of the enzymes is active at pH = 6.5? Explain. c) At what pH will the enzyme show 78% of maximal activity?
Transcribed Image Text:1. Suppose an enzyme only shows activity when the side chain -COOH group of a glutamic acid in the active site is protonated. It is known that the pKa of the side chain -COOH group is 4.07. a) Is the enzyme more active at pH 2.4 or 5.7? Explain. b) What percentage of the enzymes is active at pH = 6.5? Explain. c) At what pH will the enzyme show 78% of maximal activity?
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