16.48 Oxaloacetate is an inhibitor of succinate dehydrogenase. COO COO™ CH₂ CH₂ COO Succinate CH₂ C=O COO Oxaloacetate a. Would you expect oxaloacetate to be a competitive or a noncompetitive inhibitor? Why? b. Would oxaloacetate bind to the active site or elsewhere on the enzyme? c. How would you reverse the effect of the inhibitor?

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Chapter23: Carbohydrate Metabolism
Section: Chapter Questions
Problem 23.70E
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16.48 Oxaloacetate is an inhibitor of succinate dehydrogenase.
COO
COO™
CH₂
CH₂
COO
Succinate
CH₂
C=O
COO
Oxaloacetate
a. Would you expect oxaloacetate to be a competitive or a
noncompetitive inhibitor? Why?
b. Would oxaloacetate bind to the active site or elsewhere
on the enzyme?
c. How would you reverse the effect of the inhibitor?
Transcribed Image Text:16.48 Oxaloacetate is an inhibitor of succinate dehydrogenase. COO COO™ CH₂ CH₂ COO Succinate CH₂ C=O COO Oxaloacetate a. Would you expect oxaloacetate to be a competitive or a noncompetitive inhibitor? Why? b. Would oxaloacetate bind to the active site or elsewhere on the enzyme? c. How would you reverse the effect of the inhibitor?
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