17.44 (EX) Comparing two drugs 1/3: Makers of generic drugs must show that they do not differ significantly from the “reference” drugs that they imitate. One aspect in which drugs might differ is their extent of absorption in the blood. Table 17.5 gives data taken from 20 healthy nonsmoking male subjects for one pair of drugs. This is a matched pairs design. Numbers 1 to 20 were assigned at random to the subjects. Subjects 1 to 10 received the generic drug first, and Subjects 11 to 20 received the reference drug first. In all cases, a washout period separated the two drugs so that the first had disappeared from the blood before the subject took the second. ta17-06.xls This is a matched pairs design because each subject was evaluated on both versions of the drug. Let δ be the mean difference in absorption extent between the two versions of the drug. What is the formal hypothesis to test in comparing the two versions? What is your conclusion? A) P-value was between 0.05 and 0.1 so there was some evidence of a difference. B) P-value > 0.5 so there was no evidence of a difference. C) P-value was between 0.1 and 0.5 so there was no evidence of a difference. D) P-value < 0.05 so there was strong evidence of a difference.

Algebra & Trigonometry with Analytic Geometry

13th Edition

ISBN:9781133382119

Author:Swokowski

Publisher:Swokowski

Chapter1: Fundamental Concepts Of Algebra

Section1.4: Fractional Expressions

Problem 69E

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17.44 (EX) Comparing two drugs 1/3: Makers of generic drugs must show that they do not differ significantly from the “reference” drugs that they imitate. One aspect in which drugs might differ is their extent of absorption in the blood. Table 17.5 gives data taken from 20 healthy nonsmoking male subjects for one pair of drugs. This is a matched pairs design. Numbers 1 to 20 were assigned at random to the subjects. Subjects 1 to 10 received the generic drug first, and Subjects 11 to 20 received the reference drug first. In all cases, a washout period separated the two drugs so that the first had disappeared from the blood before the subject took the second.

ta17-06.xls

This is a matched pairs design because each subject was evaluated on both versions of the drug. Let δ be the mean difference in absorption extent between the two versions of the drug. What is the formal hypothesis to test in comparing the two versions?

What is your conclusion?

A) P-value was between 0.05 and 0.1 so there was some evidence of a difference.

B) P-value > 0.5 so there was no evidence of a difference.

C) P-value was between 0.1 and 0.5 so there was no evidence of a difference.

D) P-value < 0.05 so there was strong evidence of a difference.