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- 8. The adipose tissue is not only store triacylglycerols but also is active endocrine organ. Explain this function of the adipose tissuc. For that: a) explain the «clinical obesity» and possible consequences of the discase; b) name the biologically active molecules secreted by the adipose tissue; c) explain how secretion of these molecules changes with development of obesity. 9. A daily dict ofa 55-ycar-old woman, consisted ofa 500 g of carbohydrates, 100g of animal fats and 150 g of proteins, at the background of low physical activity.8. Ketone bodies were found in the urine of the patient with diabetes mellitus. Explain the sequence of metabolic changes resulting in ketonuria. For that answer the question and do the following tasks: a) what are the ranges of ketone bodics in blood of the healthy pcople and the patients with diabetes mellitus? b) explain the main changes in hormonal regulation of patient with diabetes mellitus; c) explain why the level of free fatty acids in the blood is clevated; d) name the pathways of lipid metabolism which becomes more active in patients with diabetes mellitus; e) draw the scheme of ketone body synthesis and oxidation.Patient who had undergone a complex maxillofacial operation could not takefood during 2 days, but glucose level in the patient's blood during that period wason the lower limit of normal. What mechanisms facilitate the maintenance ofnormal level of glucose in prolonged starvation? To answer this question:a) indicate normal fasting blood glucose level;b) draw the metabolic pathway ensuring glucose synthesis in patient's body duringa period of starvation, mark the enzymes and coenzymes;c) list the substrates of this process and its localization.
- 2.A person did not get food for 3 days and had lost his weight, ketone bodies were revealed in urine. To explain this: a)describe the main metabolic pathways providing energy for the liver cells during starvation and explain its regulation; b) discuss the hormonal changes; c)predict the deleterious effect of prolonged starvation.2. A girl decided to lose wcight and has been fasting for three days. What metabolic changes occurred in the girl's organism by the end of the 3-day fast? For answer: a) draw appropriate charts of metabolic pathways reflecting the changes in fat metabolism in the liver and adipose tissue during the prolonged fasting; b) name the hormones that accelerate these processes, and draw the charts of signal transduction of these hormoncs to the target cells; c) enumerate the regulatory enzymes with changed activity under the influence of the mentioned hormones.Nonalcoholic fatty liver disease has been linked to a sugary diet. Explain?
- 3. After 12 days of starvation, a man reduced his weight by 4 kg. The doctor prescribed him biochemical blood test to analyze the level of lipids in serum blood. The results showed an elevated level of free fatty acids and triacylglycerols. Explain the results of the biochemical blood test. For that: a) name the main hormone which manages metabolism during starvation; b) draw the scheme of this hormone action on the adipose tissue; c) name the possible pathways of fatty acids usage in the liver during starvation and write down the proper schemes.explain why natural protease inhibitors (peptide extracts from the pancreas of cattle - aprotinin) can also arrest the destruction of pancreatic proteins, but often cause an allergic reaction.8. In patients after prolonged hepatitis, the ALT and AST activities were measured in the blood serum. What transaminase activity is inereased to a greater extent, and why? For the answer: a) explain the meaning of the enzyme diagnostics; b) draw the scheme of reactions catalyzed by ALT and AST; c) point out coenzyme of these reactions; describe vitamin from which this cocnzyme is derived; d) describe the biological importance of this type of reactions in amino acid metabolism; e) specify the demands which are claimed to enzymes been used in enzyme diagnostics.
- 1. TRUE OR FALSE a) Higher Rf value will be obtained from dextrin than that of glucose in a reverse-phase TLC. b) Salivary amylase is used to hydrolyzed α(1à4) glycosidic bonds in carbohydrates.What is the relationship of glucose urine and glucose carrier protein. Pls explain in the context of diabetic patient.3) "Outline the functions of the following hormones in relation to digestion and/or the maintenance of metabolic balance: gastrin, cholecystokinin (CCK), insulin, glucagon and leptin"