4. Provide the mechanism for the conversion of heroin to morphine below using only the esterase enzyme and water (B: is a basic group). You only need to show the mechanism for the hydrolysis of one of the esters. Hint: there will be a covalent intermediate with the enzyme. B: HQ H3C. H3C H- heroin H N-CH3 esterase H₂O HO H O НО" H morphine N-CH3

4. Provide the mechanism for the conversion of heroin to morphine below using only the esterase enzyme and water (B: is a basic group). You only need to show the mechanism for the hydrolysis of one of the esters. Hint: there will be a covalent intermediate with the enzyme. B: HQ H3C. H3C H- heroin H N-CH3 esterase H₂O HO H O НО" H morphine N-CH3

Pushing Electrons

4th Edition

ISBN:9781133951889

Author:Weeks, Daniel P.

Publisher:Weeks, Daniel P.

Chapter3: Mechanisms

Section: Chapter Questions

Problem 78EQ

See similar textbooks

Similar questions

a. Enamines formed from the cyclic secondary amine pyrrolidine are important intermediates in the synthesis of 1,5-diketones. On the structures provided below, formation of an enamine from cyclopentanone and piperidine. draw the curved arrows for the reaction mechanism for the acetic acid-catalyzed H H H H eo N H H H3C- isod 1916w Proton Transfer (PT) 000 'H HO :01H SHO 6: HO H H 8²8-- H H 12.H food to shujounte sitt allarWm H OH M HO N
Useful Information: sodium metam: Commercial grade sodium metam is 33% pure sodium metam by weight and has a density of 1.2 g/mL. Hydrolysis of metam (Methyl isothiocynate) + H2S Rate constants for hydrolysis for metam (base catalyzed hydrolysis is negligible) = 300 mol -1 L. sec -1 , = 1 x 10-8 sec-1 Metam also undergoes photolysis to methyl isothiocyanate with a half-life of 1.6 hrs. Data for Sacramento River discharge Q = 75,000 L/min mean depth = 0.30 m pH = 7.8 mean width = 3.2 m dispersion coefficient D = 1.6 x 102 m2/min Assuming the spill acts acts as a single point source. How long does it take for the maximum contaminant concentration to get to Lake Shasta? If Na+ acts as conservative (i.e., it is not transformed) tracer, calculate the maximum concentration (in g/L) at Lake Shasta. (Hint: remember that sodium only constitutes a…
Write a mechanism for the following reaction. AIBN = AIBN, heat .N. CN NC CH,SH 2.
Provide the products and detailed arrow pushing mechanisms for the following reactions: OSIME3 EtN CO.Me 1. base, dilute solution (10mM) 2. NaOH/MEOH-H,0 Acid, heat CO.Me
33) Complete the following reactions H₂ Wilkinson's catalyst H₂ Ni₂B H₂/Pd Lindler catalyst H₂ Li, Liq. NH3, -78 C NH4Cl
Please
The synthesis of an azo dye is shown below. Please answer the following questions. NH2 1) Na2CO3 2) NaNO2, HCI B N-Ñ A Š3H ŠO3 Step 1 Step 2 ŠO3 2 1 1. Why you need to add Na2CO3 in step 1? (multiple answers) Oa)To decrease the solubility of compound 1 - "salting out" ob) To deprotonate compound 1, increase solubility in water Oc) To increase the reaction yield Od)To slow down the reaction rate Oe)To neutralize the HCI
4. Draw structures for products of the following reactions. PaCl, (Bu water tBu PdCI, methanol OH CHCI, NaOH, water Me,N LDA, THE, 0°C BulI (2 moles) Bri THF, -78°C Buli THE, °C Br Pd(OAch THE, 0C MeO
10. What is the major organic product generated in the reaction below? HO HO 40||!!!!!! (A) OH ...... (B) 1) 03 2) (CH3)2S HO O (C) H НО. (D)
MECHANISM ACTIVITY Base-Induced Ester Hydrolysis (Saponification) NOC XT Step 1: Nucleophilic addition of hydroxide ion to the ester carbonyl group Ahrs MPR R16 H3C. R Part A (1 of 2) Draw the curved arrows for Step 1 of this mechanism. Arrow-pushing Instructions CH3 H-O: ÖH OR' :Ö H-O: O: H H H H 1x xxx CH3 CH3 Step 1 H3C. CH3 за
Draw the structure of the expected organic product for each of the following reduction reactions. (hint: carefully consider which reducing agent is being used, and in which order!) 1. NaOH (A) isi 2. LiAlH 3. H₂O* OH (B) OH 1. H2, Pt (C) OH 1. NaBH4 2. H₂O*