(7) In a family-based alcohol use disorder genetic study, a total of 50 families, each with a pair of siblings, were recruited. The result showed that 12 families have the 1" siblings with marijuana dependence and the 2nd siblings without the disorder, while another 11 families are opposite (i.e. the 1st siblings without the disorder but the 2nd siblings with the disorder). In contrast, 20 families have both siblings exhibiting the disorder and another 17 families have both siblings without the disorder. What kind of heritability can you calculate using this family study and what is the heritability value for alcohol use disorder? A) Narrow-sense heritability, approximately 88% B) Narrow-sense heritability, approximately 44% C) Broad-sense heritability, approximately 88% D) Broad-sense heritability, approximately 44%

(7) In a family-based alcohol use disorder genetic study, a total of 50 families, each with a pair of siblings, were recruited. The result showed that 12 families have the 1" siblings with marijuana dependence and the 2nd siblings without the disorder, while another 11 families are opposite (i.e. the 1st siblings without the disorder but the 2nd siblings with the disorder). In contrast, 20 families have both siblings exhibiting the disorder and another 17 families have both siblings without the disorder. What kind of heritability can you calculate using this family study and what is the heritability value for alcohol use disorder? A) Narrow-sense heritability, approximately 88% B) Narrow-sense heritability, approximately 44% C) Broad-sense heritability, approximately 88% D) Broad-sense heritability, approximately 44%

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Description: (7) In a family-based alcohol use disorder genetic study, a total of 50 families, each with a pair ofsiblings, were recruited. The result showed that 12 families have the 1" siblings with marijuanadependence and the 2nd siblings without the disorder

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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I have seen that this was answered as C, Why is the answer C, how is that not evidence of it being genetic? Shouldnt it be none of the above? Question: Of the following, which supports the idea that alcoholism has no genetic or a low genetic component? a) Some strains of mice select alcohol over water 75% of the time, whereas others shun alcohol. b) The concordance value is 55% for MZ twins and 28% for DZ twins. c) Biological sons of alcoholic men who have been adopted have a rate of alcoholism more like that of their adoptive fathers. d) There is a 20% to 25% risk of alcoholism in the sons of alcoholic men. e) None of these.
1 (b). Nowadays, newborn babies are required to be tested for phynylketonuria (PKU), an autosomal recessive genetic disorder. If untreated, individual homozygous for PKU suffer mental retardation. In a recent year, 4 PKU babies were detected out of 126,o00 tested. Assuming Hardy-Weinberg conditions, What is the percentage of heterozygous carriers? (Give your answer in whole number, no decimal places, and include the % symbol without a space).
9, 6 77 10 9I The following 5 population genetics questions refer to this introduction: "Tay-Sachs disease is inherited as an autosomal recessive, caused by the absence of hexosaminidase-A (Hex-A). Without Hex-A a lipid accumulates in cells, particularly in the brain, resulting in homozygous recessive individuals regressing in mental and physical function until death in early childhood. Heterozygotes have abnormal Hex-A activity but manifest no disease symptoms. In a large eastern European population, the frequency of Tay-Sachs disease is 3 percent. Using this information answer the following." a) If the population is assumed to be in Hardy-Weinberg equilibrium with respect to Tay-Sachs, what is the frequency of the allele that causes Tay-Sachs (answer in two decimal points [DP])? b) What would be the frequency of heterozygotes (answer in 2 DP)? Assessment Navigator c) Assuming no assortative mating, what is the probability of two heterozygotes mating (answer in 2DP)? 1 2 3 d) In…
stion 6 of 18 Suppose that a geneticist discovers a new mutation in Drosophila melanogaster that causes the flies to shake and quiver. She calls this mutation quiver, qu, and determines that it is due to an autosomal recessive gene. She wants to determine whether the gene encoding quiver is linked to the recessive gene for vestigial wings, vg. She crosses a fly homozygous for quiver and vestigial traits with a fly homozygous for the wild-type traits, and then uses the resulting F, females in a testcross. She obtains the flies from this testcross. Phenotype Number of flies vg* qu+ 230 vg qu 224 vg qut vg* qu 97 99 Test the hypothesis that the genes quiver and vestigial assort independently by calculating the chi-squared, X², for this hypothesis. Provide the X2 to one decimal place. X2 = Does the X value support the hypothesis that the quiver and vestigial genes assort independently? Why or why not? the partial table of critical values for X2 calculations to test this hypothesis.
Concordance studies of twins for a neurodegenerative disorder show MZ= 46% and DZ= 15%. Further studies have shown a possible link to a gene on chromosome 9, however, there are some individuals in the study who have the allele but do not develop the disorder (group 1), and there are other individuals who do not have the allele yet develop the disorder (group 2). Amita's older sister and maternal uncle have this disorder. Currently, Amita & her 2 younger brothers do not show symptoms. Amita's paternal grandfather was rumored to have this disorder. 1. Draw the pedigree for Amita's family and determine the mode of inheritance if any. 2. Explain how the 2 groups in the study could be possible? 3. What would you tell Amita about the heritability of this disorder?
One particularly useful feature of the Hardy-Weinberg equation is that it allows us to estimate the frequency of heterozygotes for recessive genetic diseases, assuming that Hardy-Weinberg equilibrium exists. As an example, let’s consider cystic fibrosis, which is a human genetic disease involving a gene that encodes a chloride transporter. Persons with this disorder have an irregularity in salt and water balance. One of the symptoms is thick mucus in the lungs that can contribute to repeated lung infections. In populations of Northern European descent, the frequency of affected individuals is approximately 1 in 2500. Because this is a recessive disorder, affected individuals are homozygotes. Assuming that the population is in Hardy-Weinberg equilibrium, what is the frequency of individuals who are heterozygous carriers?
Leber Congenital Amaurosis (LCA) causes progressive vision loss due to defects in the gene that encodes RPE65 isomerase. Affected individuals are homozygous recessive for mutant alleles of the RPE65 gene. You are trying to determine the molecular nature of the mutations in three individuals with LCA. For ease of analysis, you may assume that each individual is homozygous for the same mutant allele (though the three individuals have different mutations than each other). You use the polymerase chain reaction to amplify DNA from each patient and you determine the sequence of the DNA and compare it to unaffected individuals. You identify the following differences. Note that the non-template strand of DNA is given and the changes are highlighted using red boldface. You can assume that the sequences are in the first reading frame (eg. the first three nucleotides of each sequence is a codon). The coding region of the gene is 1602 bp and the position of the sequences shown below is…
A woman diagnosed with early-onset Alzheimer's due to a mutation of the APP genehas children with a man that has no family history of familial Alzheimer's. Give the probability of each possible genotype with corresponding phenotype. (The woman has two possible allele combinations. You must show both possibilities)
*22. Dent disease is a rare disorder of the kidney in which reabsorption of filtered solutes is impaired and there is progressive renal failure. R. R. Hoopes and colleagues studied mutations associated with Dent disease in the following family (R. R. Hoopes et al. 2005. American Journal of Human Genetics 76:260-267): II 2 3 4 5 II 3 4 5 6 7 8 IV a. On the basis of this pedigree, what is the most likely mode of inheritance for the disease? Explain your reasoning. b. Based your answer to part a, give the most likely genotypes for all family members in the pedigree.
Normal wife Affected husband As a genetic counsellor you are presented with a married couple where one of them has a family history of this disease. The husband is affected by this disease and the wife is normal. The couple, who are thinking of starting a family, would like to know what their chances are of having a child born with this condition. They would also like to know what the probabilities are of having an affected boy or affected girl. Use the symbols above to complete the diagram right and determine the probabilities stated below (expressed as a proportion or percentage). Parents 4. Determine the probability of having: Gametes (a) Affected children: Possible (b) An affected girl: fertilizations (c) An affected boy: O O O O Children Affected aite if 耳

Take the example of B-thalassemia, an autosomal recessive genetic disease that particularly affects people from around the Mediterranean. This disease is associated with an anomaly of hemoglobin, a protein essential for the transport of oxygen, which is composed of four chains: two alpha (a) and two beta (B). In case of B-thalassemia, the ẞ chains are produced in insufficient or no quantity in an individual homozygous recessive resulting in insufficient production of overall hemoglobin leading to anemia and other physiological challenges. The gene that controls the synthesis of the ẞ chains is located on chromosome 11. Here is part of the coding portion of this gene (which controls a total of 146 amino acids and of which you only see the portion 36 to 41) and one of the targeted mutations: 1. Give the sequence of amino acids from the template and mutated strands. 2. What type of point mutation is it? 3. Using the principles of the theory of evolution, explain briefly and generally why…
Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?