7. Warfarin is a blood thinner known by its tradename Coumadin. Warfarin has a formula mass of 308.33 g/mol and a pka of 5.0. Sun et al (J. Pharm. Biomed. Anal. (2006) 42, 218-222) reported a plasma concentration of 567.6 ng/ml. (1.84 uM) warfarin in patients within one month of heart valve treatment. Blood pH is 24. What percent of warfarin in the plasma is not deprotonated? The body has 5.0L of blood.

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7. Warfarin is a blood thinner known by its tradename Coumadin. Warfarin has a formula mass of 308.33 g/mol and a pka of 5.0. Sun
et al (J. Pharm. Biomed. Anal. (2006) 42, 218-222) reported a plasma concentration of 567.6 ng/ml. (1.84 uM) warfarin in patients
within one month of heart valve treatment. Blood pH is Z4. What percent of warfarin in the plasma is not deprotonated? The body
has 5.0L of blood.
но
22, warfarin
Transcribed Image Text:7. Warfarin is a blood thinner known by its tradename Coumadin. Warfarin has a formula mass of 308.33 g/mol and a pka of 5.0. Sun et al (J. Pharm. Biomed. Anal. (2006) 42, 218-222) reported a plasma concentration of 567.6 ng/ml. (1.84 uM) warfarin in patients within one month of heart valve treatment. Blood pH is Z4. What percent of warfarin in the plasma is not deprotonated? The body has 5.0L of blood. но 22, warfarin
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