A 300g red squirrel in a flow through respirometry chamber consumed 0.27 l O2/hr. a. What is it’s metabolic rate in kcal/hr? a. What is its metabolic rate per kg body mass?

HbR is reported to have P50=14torr and a Hillcoefficient=1.2. Calculate ΔYO2 for a climber with HbR assuming that, at 14,000 ft (∼4300m), PO2=43mmHg in lungs and PO2=10mmHg in muscle capillaries.

A 60 kg patient is on a continuous IV constant rate infusion of theophylline at 30 mg/h. His steady-state concentration is determined to be 12 mg/L. If you assume the theophylline distribution volume to be 22 L, what would be the patients plasma concentration 4 hours after the continuous infusion stopped? Please select one: 0 a. 6.5 mg/L b. 7.6 mg/L c. 4.8 mg/L d. 8.4 mg/L e. 3.7 mg/L

The solubility of CO2 in blood is about 0.062 mL dL-1 mmHg-1. Arterial blood has a Pa_CO2 = 40 mm Hg and venous blood has PV_CO2 = 46 mm Hg, and cardiac output is 5 L min-1. A. Calculate the content of dissolved CO2 (in mL dL-1) in arterial and venous blood and how much CO2 is removed from the tissues and delivered to the lungs per minute. (Hint: CO2 content = solubility of CO2 * PCO2) (Hint: Rate of CO2 transport = cardiac output * (arterial CO2 content – venous CO2 content) B. If the volume diffusion rate of CO2 = 200 mL min-1 in the lung, what fraction of the total CO2 removal is accomplished through carrying dissolved CO2? C. Describe the effects of increased P CO2 and H+ concentration on the oxygen-hemoglobin dissociation curve. How are these effects adaptive for oxygen unloading in the tissues?

Following several days at high altitude the body responds to the decreased oxygen content of the atmosphere by increasing the amount of 2,3-bisphosphoglycerate it produces. Based on this information and refering to the graph below, identify the correct response from the options. Y (fraction saturation) 1.0 0.8 0.6 0.4 0.2 0.0 0 20 Oxygen Binding plot 40 60 p02 (torr) 80 100 A) Curve y=high altitude and gives a greater release of oxygen to the tissues B) Curve x = high altitude and gives a greater release of oxygen to the tissues C) Curve y=high altitude and allows more oxygen to be bound at low oxygen levels D) Curve x = high altitude and allows more oxygen to be bound at low levels

A patient carrying a mutant form of hemoglobin (KD = 48 torr) is planning to take part in a hiking trip that involves strenuous physical activity at ~10,000 feet above sea level. The mutant hemoglobin has reduced oxygen binding cooperativity (n = 2.2) and displays no major structural abnormalities.   a. Calculate the percent saturation of hemoglobin in the lungs (pO2 = 70 torr at this elevation) for this patient and for an individual carrying a normal version of hemoglobin   b. Calculate the percent saturation of hemoglobin in active skeletal muscle tissue (pO2 = 15 torr) for this patient and for an individual carrying a normal version of hemoglobin   c. Will this patient transport oxygen from the lungs to active muscle tissues more or less efficientlythan an individual with a normal version of hemoglobin on this trip? Briefly explain your answer

Inorganic compounds of metallic mercury are presumed from metabolic studies to distribute uniformly after inhalation or ingestion with 8% going to the liver and 92% to the total body. Biological clearance of mercury in each of these tissues occurs by two compartments, 95% with a biological half-life of 40 days and the remaining 5% with a biological half-life of 10,000 days. For an intake of 1 MBq of 203Hg (Tr= 46.61 d). Determine the following 1. Total number of transformations in the Liver. 2. Total number of transformations in the total body.

2,3-bisphosphoglycerate (BPG) is a negative allosteric regulator of hemoglobin that is produced in red blood cells. Normally, red blood cell levels of BPG are 5 mmol/L, yielding curve 2. Individuals acclimated to high altitudes can have BPG levels of 8 mmol/L to optimize their oxygen utilization. Saturation 2 3 S Which curve represents hemoglobin of someone living at normal altitudes? 1 2 Pos (mm Hg) 3 None of the answers are correct 2 and 3

The following data describe the binding of oxygen to human myoglobin. Posygen (mm Hg) Percent Saturation 0.5 16.1 2.0 27.7 3.0 53.5 4.0 60.5 6.0 69.7 8.0 75.4 12.0 82.1 20.0 88.5 From these data the approximate P50 (mm Hg) value is: A. 1.0 В. 1.4 С. 1.9 D. 2.6 Е. 3.2 F. 3.5 G. 3.7 Н. 3.9 I. 4.0

Which option best describes the following figure? Y (fraction saturation) 1.0 0.8 0.6 0.4 0.2 0.0 0 20 Oxygen Binding plot 40 60 p02 (torr) 80 100 A) Curve x = adult haemoglobin, curve y = fetal haemoglobin B) Curve x = myoglobin, curve y = haemoglobin C) Curve x = fetal haemoglobin, curve y = adult haemoglobin D) Curve x = fetal haemoglobin, curve y = myoglobin E) Curve x = adult haemoglobin, curve y - myoglobin