VI. Although most biologically relevant sugars have the D-configuration, L-fucose is a commonly observedmonosaccharide component in glycoproteins. Glycosylated antibodies (IgGs) observed in patients withactive TB have more fucose than those found in patients with latent TB (Lu et. al., 2016). Latent TB occurswhen a person has the TB bacteria, but bacterial proliferation is kept under control by the body's immunesystem; hence, the infected person is asymptomatic and not infectious. A person with latent TB will testpositive for the tuberculin test or TB blood test.a) L-fucose is also known as 6-deoxy-L-galactose. Note that D-galactose is a C-4 epimer of D-glucose.Draw the Fisher projections for D-glucose, D-galactose and L-fucose. (Hints: D- and L-isomers areenantiomers. 6-deoxy means that the hydroxyl group at C-6 is removed leaving just the methyl group).D-galactose:D-glucose:L-fucose(6-deoxy-L-galactose):b) L-fucose can cyclize into a pyranose and form two anomers. Draw the Haworth diagrams for the a- andß- anomers of L-fucose.a-L-fucopyranose:B-L-fucopyranose:

Carbohydrates are polyhydroxy aldehydes or ketones. They can be classified as monosaccharides,…

Answered: a) L-fucose is also known as…

Basic Clinical Laboratory Techniques 6E

6th Edition

ISBN:9781133893943

Author:ESTRIDGE

Publisher:ESTRIDGE

Chapter6: Basic Clinical Chemistry

Section6.1: Introduction To Clinical Chemistry

Problem 9RQ

See similar textbooks

Similar questions

2B. S. aureus hemolysin B attacks the RBC cell membrane by hydrolyzing the sphingomyelin headgroup: ОН HN .R hemolysin B cuts this bond i) Draw a plausible mechanism of hydrolysis for this lipid headgroup. Let B- and BH be general base and general acid. 00-P-O LOR2 OR, ii) Why is this damaging to the overall membrane architecture of the RBC?
8. Hypercholesterolemia is a frequent complication of diabetes mellitus in patients with prolonged hyperglycemia. Why a high level of glucose in blood causes hypercholesterolemia and atherosclerosis? For the answer explain: a) how glucose can interact with the proteins and the consequences of this reaction for the proteins; b) glycation of which proteins results in hypercholesterolemia; c) possible causes and complications of hypercholesterolemia.
The figure shows interaction of various amino acids (Phe, Arg, and Asn) present in Hb with 2,3-DPG. The side chains of these amino acids and 2,3-DPG interactions are circled in red. HO Но Phe HN Asn H2N NH Arg You identify a mutant version of the globin chain where the Arg in circle 2 is replaced with aspartic acid in a patient. Would the Hb protein in this patient be able to transport oxygen even in the presence of 2,3-DPG? ASPARTIC ACID (asp) No, because the mutant Hb version will bind 2,3 DPG, and not oxygen Yes, because the mutant Hb version will bind 2,3 DPG, and not oxygen Yes, because the mutant Hb version will bind oxygen and not 2,3 DPG
4 A I. Refer to the figure below and answer the following questions: 45 5 55 6 65 PH 7 75 8.5 0 10 B 15 20 25 30 35 Temperature (°C) 40 45 Legend: Blue - wild-type ß-galactosidase; Red - mutant ß-galactosidase a. What is the optimum pH of wild type ß-galactosidase? b. What is the optimum temperature of mutant ß-galactosidase? c. Which enzyme has the greater activity at pH 7.2? d. Which enzyme has the greater activity at a temperature of 42.5°C? e. Which enzyme has greater activity if pH decreases from 7.5 to 6.4? f. Which enzyme has greater activity if temperature increases from 40°C to 41 °C? 50 55
I. A protein, X, was Isolated from a pathogenlc mlcroorganism. The proteln Is a vlrulence factor whose path0genlclty lies In a heptapeptide of unknown sequence. After trypsin cleavage of the heptapeptide from protein X, the peptlde's compOsition and sequence was determined. The fOllowing were the results of the sequenclng process: 1. When the peptide was treated with dinitrofluorobenzene (DNFB), DNP-asp and a mixture of amino acids were produced. 2. When the same Intact peptide was treated with streptococcal protease, a pentapeptide of composition asp, asN, cys, gly and ser and 2 amlno acids were released. 3. When the heptapeptlde was also treated with hydrOxylamine HCI, a tripeptide and a tetrapeptide were obtained. The C-terminal amino acid of the tripeptide was asN. 1) What is the sequence of the heptapeptide if it is composed of cys, asp, lys, asN, gly and ser only? 2) What is the pl of the heptapeptide?
Indicate whether the following sentences is either True or False and CORRECT if False : Monomeric α-catenin binds strongly to E-cadherin-β-catenin; and the dimer binds to intergrins.
(c) Which phase of cell growth is disrupted by antimetabolites? Explain how as folate methotrexate functions antagonist. antimabolites
Polyethylene glycol (PEG)-conjugated IFNs have superior pharmaceutical properties compared with their unconjugated counterparts as a result of greater protection against proteolytic degradation, better solubility, and slower catabolism and excretion. Group of answer choices True False
Co ? ull| 58%| 1:31 AM Topic 5_Proteins.. WMSU-ISMP-GU-001.00 Effective Date: 7-DEC-2016 See if you can do this! 1. Indicate whether each of the following molecules is an alpha amino acid or not and explain why. a. H,N-CH-C-OH b. H,N-C-CH,CH,CH; CH-OH ČH3 c. CH;CH;CH-CH,–NH, HO-C -CH-CH;CH(CH3)½ NH, d. OH 2. Which of the following forms of lysine would you expect to predominate at low pH, neutral pH, and high pH? H но H NH,- CH)4 NH,+ NH,- (CH)4 NH,- -C-O C-Ĉ-OH a. b. с. (CH)4 NH,+ NH, 3. One of the 20 standard amino acids is unusual in that its side chain contains a ring that incorporates the amine functional group of the amino acid. What is the name of this amino acid? What is its three-letter abbreviation and one-letter code? Write the chemical structure of this amino acid at physiological pH. 4. Draw the structure of valine at pH 1.0 and at pH 12.0. 26
Classify the symmetrical arrangement ofthe subunits (e.g., C2 , C3 , D 2 , helical, icosahedral). 1. Proteobacterial nitrite sensor (3PNS):2. Pseudomonad oligosaccharide receptor (7POR):3. Adenoviral structural protein (8ASP)
a. When a chromophore binds to proteins, the binding site is generally more hydrophobic than the solution. Then, what kind of shift do you expect to observe in the absorption peak position compared to the peak observed when the chromophore is free in solution?
I. How much of a 10 mg/mL lysozyme stock would you need to add to 4 mL of cells for a final concentration of 1 mg/mL? What is the lysozyme doing?

SEE MORE QUESTIONS

Recommended textbooks for you

Basic Clinical Laboratory Techniques 6E

Biology

ISBN:

9781133893943

Author:

ESTRIDGE

Publisher:

Cengage

Basic Clinical Laboratory Techniques 6E

Biology

ISBN:

9781133893943

Author:

ESTRIDGE

Publisher:

Cengage

SEE MORE TEXTBOOKS