A man was prescribed barbiturates 6 months ago. However, with time the physician had to increase the daily dosage to maintain the same therapeutic drug level for his seizure disorder. Why is this occurring? a) upregulation of drug receptors on neurons b) decreased absorption from stomach c) induction of neuronal metabolism d) induction of drug metabolizing enzymes in liver

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
ChapterCRE1: Comprehensive Review Exam For Part 1
Section: Chapter Questions
Problem 15CEP1
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A man was prescribed barbiturates 6
months ago. However, with time the
physician had to increase the daily
dosage to maintain the same
therapeutic drug level for his seizure
disorder. Why is this occurring? a)
upregulation of drug receptors on
neurons b) decreased absorption
from stomach c) induction of
neuronal metabolism d) induction of
drug metabolizing enzymes in liver
Transcribed Image Text:A man was prescribed barbiturates 6 months ago. However, with time the physician had to increase the daily dosage to maintain the same therapeutic drug level for his seizure disorder. Why is this occurring? a) upregulation of drug receptors on neurons b) decreased absorption from stomach c) induction of neuronal metabolism d) induction of drug metabolizing enzymes in liver
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