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A microsatellite locus can show linkage to a disease gene (a) Parental genotypes M" Key + + PCR primers Dominant disease allele Microsatellite repeats M - M" Molecular markers (b) Banding patterns of parents and children M M" M' FIGURE 4-15 A PCR banding pattern is shown for a family with six children, and this pattern is interpreted at the top of the illustration with the use of four different- size microsatellite "alleles," M' through M". One of these markers (M") is probably linked in cis configuration to the disease allele P. (Note: This mating is not a testcross, yet is informative about linkage.) PCR products

A microsatellite locus can show linkage to a disease gene (a) Parental genotypes M" Key + + PCR primers Dominant disease allele Microsatellite repeats M - M" Molecular markers (b) Banding patterns of parents and children M M" M' FIGURE 4-15 A PCR banding pattern is shown for a family with six children, and this pattern is interpreted at the top of the illustration with the use of four different- size microsatellite "alleles," M' through M". One of these markers (M") is probably linked in cis configuration to the disease allele P. (Note: This mating is not a testcross, yet is informative about linkage.) PCR products

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Using the conventions of Figure 4-15, draw parents and
progeny classes from a cross
P M′′′/p M′ × p M′/p M′′′′

A microsatellite locus can show linkage to a disease gene (a) Parental genotypes M" Key + + PCR primers Dominant disease allele Microsatellite repeats M - M" Molecular markers (b) Banding patterns of parents and children M M" M' FIGURE 4-15 A PCR banding pattern is shown for a family with six children, and this pattern is interpreted at the top of the illustration with the use of four different- size microsatellite "alleles," M' through M". One of these markers (M") is probably linked in cis configuration to the disease allele P. (Note: This mating is not a testcross, yet is informative about linkage.) PCR products
Transcribed Image Text:A microsatellite locus can show linkage to a disease gene (a) Parental genotypes M" Key + + PCR primers Dominant disease allele Microsatellite repeats M - M" Molecular markers (b) Banding patterns of parents and children M M" M' FIGURE 4-15 A PCR banding pattern is shown for a family with six children, and this pattern is interpreted at the top of the illustration with the use of four different- size microsatellite "alleles," M' through M". One of these markers (M") is probably linked in cis configuration to the disease allele P. (Note: This mating is not a testcross, yet is informative about linkage.) PCR products
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