A new technique for rapidly determining the nuclesome structure for regions of chromatin is called Mnase-Seq. Briefly, in MNase-Seq experiments, the chromatin is digested with Micrococcal Nuclease (MNase) and then the resulting digest is subjecting to high throughput sequencing to identify sequences digested by enzyme. See this short article for complete explanation. In the experiment below, researchers conducted an Mnase Seq experiment on a region of a chromosome in the absence (OHT-) and presence (OHT+) of a Protein X. This protein has a dramatic effect on the expression of the Igll1 gene, but no effect on Top3b nor Vpreb1 genes. Based on this information, explain what Protein X is doing to influence the Igll1 gene (limit 4-5 sentences).

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A new technique for rapidly determining the nuclesome structure for regions of chromatin is called Mnase-Seq. Briefly, in MNase-Seq experiments, the chromatin is digested with Micrococcal Nuclease (MNase) and then the resulting digest is subjecting to high throughput sequencing to identify sequences digested by enzyme. See this short article for complete explanation.

In the experiment below, researchers conducted an Mnase Seq experiment on a region of a chromosome in the absence (OHT-) and presence (OHT+) of a Protein X. This protein has a dramatic effect on the expression of the Igll1 gene, but no effect on Top3b nor Vpreb1 genes. Based on this information, explain what Protein X is doing to influence the Igll1 gene (limit 4-5 sentences).

gene, but no effect on Top3b nor Vpreb1 genes. Based on this information, explain what Protein X is
influence the Igll1 gene (limit 4-5 sentences).
Chr 16: 16,870,000
MNase-seq
A
4-OHT
0 min
360 min
Ton?t
Vereb1
16,866,000
lall
16,862,000
1kb
Transcribed Image Text:gene, but no effect on Top3b nor Vpreb1 genes. Based on this information, explain what Protein X is influence the Igll1 gene (limit 4-5 sentences). Chr 16: 16,870,000 MNase-seq A 4-OHT 0 min 360 min Ton?t Vereb1 16,866,000 lall 16,862,000 1kb
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