a) The conversion of a-cyanoketone 1 to the cyclononanone 2 by treatment with a fluoride source, Appelconditions, and mildly basic conditions, respectively.NCWOTBSMeNOPMBMeb) The epimerization of this cis-fused tetracyclic enone to the trans-fused diastereomer (hint: think'retro vinylogous Mannich reaction').3Me Me10NMea) HF pyridineb) NBS, PPh3c) DBUHNCD₂0D₂SO4 (cat.)MeN2MeOPMBMe MeH4HighliNMe

Kindly repost your question (b) because these are not interrelated. Thanks you

a) The conversion of a-cyanoketone 1 to the cyclononanone 2 by treatment with a fluoride source, Appel conditions, and mildly basic conditions, respectively. NC OTBS OPMB O a) HF pyridine b) NBS, PPh3 c) DBU NC 2 O Highl OPMB

a) The conversion of a-cyanoketone 1 to the cyclononanone 2 by treatment with a fluoride source, Appel conditions, and mildly basic conditions, respectively. NC OTBS OPMB O a) HF pyridine b) NBS, PPh3 c) DBU NC 2 O Highl OPMB

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

a) The conversion of a-cyanoketone 1 to the cyclononanone 2 by treatment with a fluoride source, Appel
conditions, and mildly basic conditions, respectively.
NC
W
OTBS
MeN
OPMB
Me
b) The epimerization of this cis-fused tetracyclic enone to the trans-fused diastereomer (hint: think
'retro vinylogous Mannich reaction').
3
Me Me
10
NMe
a) HF pyridine
b) NBS, PPh3
c) DBU
H
NC
D₂0
D₂SO4 (cat.)
MeN
2
Me
OPMB
Me Me
H
4
Highli
NMe

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