Barbiturates are prepared by treating a derivative of diethyl malonate with urea in the presence of sodium ethoxide as a catalyst. Following is an equation for the preparation of barbital, a long-duration hypnotic and sedative, from diethyl diethylmalonate and urea. -OEt H,N -NH 1. EtO-Na+ + 2 ELOH 2. Н,О -OEt H,N -NH Diethyl diethylmalonate Urea 5,5-Diethylbarbituric acid (Barbital) Barbital is prescribed under one of a dozen or more trade names.
Barbiturates are prepared by treating a derivative of diethyl malonate with urea in the presence of sodium ethoxide as a catalyst. Following is an equation for the preparation of barbital, a long-duration hypnotic and sedative, from diethyl diethylmalonate and urea. -OEt H,N -NH 1. EtO-Na+ + 2 ELOH 2. Н,О -OEt H,N -NH Diethyl diethylmalonate Urea 5,5-Diethylbarbituric acid (Barbital) Barbital is prescribed under one of a dozen or more trade names.
Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter19: Carboxylic Anhydrides, Esters, And Amides
Section: Chapter Questions
Problem 19.45P
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Propose a mechanism for this reaction
![Barbiturates are prepared by treating a derivative of diethyl malonate with urea in the
presence of sodium ethoxide as a catalyst. Following is an equation for the preparation of
barbital, a long-duration hypnotic and sedative, from diethyl diethylmalonate and urea.
-OEt
H,N
-NH
1. EtO-Na+
+ 2 ELOH
2. Н,О
-OEt
H,N
-NH
Diethyl
diethylmalonate
Urea
5,5-Diethylbarbituric acid
(Barbital)
Barbital is prescribed under one of a dozen or more trade names.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F52751c70-dc9c-4506-bb49-188f6167278e%2F5afc7e9b-a2c3-4a78-90f3-3bc2672ef857%2Fi5z2f5.jpeg&w=3840&q=75)
Transcribed Image Text:Barbiturates are prepared by treating a derivative of diethyl malonate with urea in the
presence of sodium ethoxide as a catalyst. Following is an equation for the preparation of
barbital, a long-duration hypnotic and sedative, from diethyl diethylmalonate and urea.
-OEt
H,N
-NH
1. EtO-Na+
+ 2 ELOH
2. Н,О
-OEt
H,N
-NH
Diethyl
diethylmalonate
Urea
5,5-Diethylbarbituric acid
(Barbital)
Barbital is prescribed under one of a dozen or more trade names.
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