Based on the list of intra- and extracellular concentrations shown below, ( ) is probably used as a source of energy for the externalization (movement to the outside) of some molecules, while () is more likely to serve as a signaling molecule. Table 11-1 A Comparison of lon Concentrations Inside and Outside a Typical Mammalian Cell COMPONENT Cations Na K+ Mg2+ Ca²+ H+ A. K+, Ca2+ B. Na+, K+ C. Mg2+, Ca2+ D. Ca+,H+ E. K+, Na+ INTRACELLULAR CONCENTRATION (mm) 5-15 140 0.5 104 7 x 10-5 (10-7-2M or pH 7.2) EXTRACELLULAR CONCENTRATION (mm) 145 5 1-2 1-2 4x 10-5 (10-74 M or pH 7.4)
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- Animal cells utilize rapid increases in cytosolic Ca++ ion concentration to respond to certain extracellular signals. This requires keeping the cytosolic Ca++ ion concentration very low in the absence of signal (when the cell is “at rest”) and increasing the cytosolic Ca++ ion concentration when a signal is detected. Propose a mechanism by which the action of Ca++ transport proteins in the plasma membrane can account for the reversibility of Ca++ levels in the cytosol. Be sure to indicate whether active or passive transport is involved as well as the type of transport protein (channel or carrier) responsible.What is the energy requirement to transport 3 mol of Na+ across the membrane by the Nat-K+ ATPase transporter protein at 37 °C under conditions in which the membrane potential is 70 mV (the inside of the cell is negative relative to the outside) and the ion concentrations are as follows: + [K*]outside = 5 mM [K+Jinside = 140 mM [Na]outside = 150 mM [Na]inside = 10 mM O-41.22 kJ + 13.74 kJ +41.22 kJ O-13.74 kJIntestinal epithelial cells pump glucose into the cell against its concentration gradient using the Na+– glucose symporter. Recall that the Na+ concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Na+ ions into the cell to the "uphill" transport of glucose into the cell. If the Na+ concentration outside the cell ([Na+]out) is 163 mM and that inside the cell ([Na+]in) is 21.0 mM, and the cell potential is −54.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C.
- Pls send solution fast within 10 minutes and i will give like for sure Solution must be in typed form Calcium ions bind to the SERCA Ca2+ -ATPase, which has two identical calcium sites, in two stages with apparent equilibrium constants K1=7×105M−1 and K2=2×106M−1 . a.) Calculate K. Note: K is not 0.1*1013 or 14*1011 or 1*1012. b.) Calculate τ.Intestinal epithelial cells pump glucose into the cell against its concentration gradient using the Nat-glucose symporter. Recall that the Na+ concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Na+ ions into the cell to the "uphill" transport of glucose into the cell. If the Na+ concentration outside the cell ([Na+]out) is 155 mM and that inside the cell ([Na+ lin) is 21.0 mM, and the cell potential is -52.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C. AGgluc = kJ mol What is the maximum ratio of [glucose] in to [glucose]out that could theoretically be produced if the energy coupling were 100% efficient? O 2700 7.89 O 1.14 3.7 x 10-4Intestinal epithelial cells pump glucose into the cell against its concentration gradient using the Na*-glucose symporter. Recall that the Na+ concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Na+ ions into the cell to the "uphill" transport of glucose into the cell. If the Na+ concentration outside the cell ([Na* lout) is 147 mM and that inside the cell ([Na+]in) is 17.0 mM, and the cell potential is -54.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C. AG gluc kJ mol What is the maximum ratio of [glucose]in to [glucose] out that could theoretically be produced if the energy coupling were 100% efficient? 1.13 2.3 × 10-4 8.36 4300
- O Att Intestinal epithelial cells pump glucose into the cell against its concentration gradient using the Nat-glucose symporter. Recall that the Nat concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Nat ions into the cell to the "uphill" transport of glucose into the cell. If the Nat concentration outside the cell ([Na lout) is 161 mM and that inside the cell ([Na* Jm) is 17.0 mM, and the cell potential is -50.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C. What is the maximum ratio of (glucose] to [glucoselout 10.62 kJ AG gluc mol that could theoretically be produced if the energy Incorrect coupling were 100% efficient? O 1.13 8.24 3800 2.6 x 10 IncorrectVery briefly, explain how increased cytoplasmic IP3 levels can then increase cytoplasmic calcium (Ca2+) levels.Intestinal epithelial cells pump glucose into the cell against its concentration gradient using the Na-glucose symporter. Recall that the Na* concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Na* ions into the cell to the "uphill" transport of glucose into the cell. If the Nat concentration outside the cell ([Na lout) is 141 mM and that inside the cell ([Na* lin) is 19.0 mM, and the cell potential is -52.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C. AGglac 9.63 Incorrect kJ mol What is the maximum ratio of [glucose), to [glucose)out that could theoretically be produced if the energy coupling were 100% efficient? O 2700 1.13 3.7 x 10- 7.90
- Second-messenger systems ultimately bring about the desired cell response by inducing a change in the shape and function of particular designated intracellular proteins. (True or false?)One of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?Although purified actin can assemble reversibly in vitro, various actin-binding proteins regulate the assembly of actin filaments in the cell. Predict the effect on a cell’s actin cytoskeleton if function-blocking antibodies against each of the following were independently microinjected into cells: profilin, thymosin-β4, CapZ, and the Arp2/3 complex.