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Briefly describe the four major categories of pathogen. Which are likely to be the most homogenous in form and which the most diverse? Why?
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- Below are a list of virulence factors/ strategies paired with an example of an organism that utilizes them. How do each of the following strategies contribute to the virulence of the pathogen? Strategy - Causes the host to produce more receptors (Organism - Rhinovirus) Strategy - Produces gas as a product of fermentation (Organism - Clostridium perfringens) Strategy - Produces a capsule (organism - Klebsiella pneumonia) Strategy - Ability to move between adjacent cells (organism - Cytomegalovirus) Strategy - Ability to use pilus as a motility structure (organism - Pseudomonas aerogenosa)What is epidemiology? there are several ways pathogens can be transmitted including direct contact, indirect contact, via respiratory droplets, vehicle, and through a vector. Describe each mode IN DETAIL and give an example of a pathogen that can be transmitted each way.Which of the following virulence factors among A-D is correctly matched with its definition or characterization? A) O Invasins: pathogen proteins that prevent opsonization of the pathogen B) O Phase variation: allows pathogen to switch between different forms of an extracellular antigen (e.g., flagellum) C) O Protein A. a microbial factor that allows for attachment, typically a surface protein or surface glycoprotein D) O Prevention of lysosome:phagosome fusion mechanism employed by an extracellular pathogen E) OM protein, Opa protein: enzymes that interfere with the functioning of antibodies
- Select all of the following that applies to the tradeoff between transmission and virulence that applies to many diseases. a) The tradeoff between transmission and virulence means that diseases always evolve to become more virulent. b) If greater virulence limits transmission, that disease will likely evolve to become less virulent than it could be. c) While making more copies of itself can increase the likelihood of transmission occurring, too much replication of the disease can make the host so sick it won't leave the house and spread the disease. d) A strain of a disease that replicates enough to be transmitted, but not so much that the host gets too sick to move, will be favored by natural selection over strains that either make the host too sick or do not replicate enough to be transmitted. e) If a disease can spread without making its host sick (e.g. when the host is asymptomatic), then the tradeoff between transmission and virulence…Discuss the following virulence factors: collagenase, hemolysin, siderophore. For each, explain the molecules involved, the pathogen-host interaction, and name a species and disease associated with each factor.What is meant by an opportunistic pathogen?
- C. bot and C. tetani are considered true pathogens while C. dificile is considered an opportunist. What do we know about the pathogens from these classifications?Identify three bacterial structures linked to virulence and pathogenicity.Which of the following is NOT true of bacterial exotoxins? 1. Important in the pathogenesis of many human diseases 2. Their toxic effect can be systemic, affecting cells distant from the primary site of infection 3. None of the other four answers (All are true of bacterial exotoxins) 4. Different exotoxins may affect different types of cells (e.g., nerves, gastrointestinal mucosa) 5. Some exotoxins have two components, A (active) and B (binding)