Calculate the free-energy difference between the stable and unstable chair conformation of each the following trimethylhexanes. CH, CH, CH3 CH3 "CH3 B Support your answer with the drawing of conformer(s) and show your calculations. Energy cost by: H+CH3 eclipsed CH;++CH, gauche 1,3-diaxial (He»CH;) strain 1,3-diaxial (CH3+ACH;) strain Energy (kJ mol"') 6.0 3.8 3.8 15.4
Q: 1. What happens to the axial bonds when a chair conformation is converted to another chair…
A: During ring inversion process, When a chair conformation is converted into another chair…
Q: The cyclohexane derivative shown exists primarily in the more stable of the two available chair…
A: See answer below.
Q: 4. Draw the most and least stable conformations of the following substituted cyclohexanes in the…
A: For most stable chair conformation, the bulky group is attached to the equatorial position
Q: Calculate the ratio of the diequatorial to diaxial conformation of this disubstituted cyclohexane at…
A: Both the methyl groups are present at the axial positions in this structure: If the methyl groups…
Q: . Write the two chair conformations of each of the following and in each part designate which…
A: According to guidelines i can answer only first question
Q: Starting from the bond-line structure provided, complete the Haworth, Chairs, and Newman structures…
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Q: The cyclohexane derivative shown exists primarily in the more stable of the two available chair…
A: The most stable conformation of the chair is given as follows
Q: 3) Draw both chair conformations of (1S,3R)-1-chloro-3-isopropylcyclohexane. Clearly mark the most…
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Q: Cyclohexane derivatives exist primarily in the most stable of the available chair conformations.…
A: Most stable chair conformation is that faces least strain interaction. Thus to draw the most stable…
Q: How many energetically different eclipsed conformations does 1-bromo-2-methylpropane, viewed along…
A: The Newmann projections are stable when two bulky groups or atoms have a decent separation between…
Q: Construction a qualitative potential energy for rotation about the C C Bond of 1,2-dibromoethane.…
A: The main conformations of 1,2-dibromoethane are: staggered anti, staggered gauche, and eclipsed…
Q: Using the letters in the diagrams above, complete the labeling of all staggered conformations and…
A: The Newman structure is a 2D representation of the molecule along the carbon-carbon bond. In this…
Q: Draw both chair conformations of compound M on the templates (X and Y) provided. Indicate which…
A: The position of groups on the chair confirmation can be determined as– Here all the substitutents…
Q: The cyclohexane derivative shown exists primarily in the more stable of the two available chair…
A: Chair conformation is most stable of cyclohexane and groups are placed on respective equatorial and…
Q: Cyclohexane derivatives exist primarily in the most stable of the available chair conformations.…
A: Given structure of the molecule is : a = axial position e = equatorial position For…
Q: Cyclohexane derivatives exist primarily in the most stable of the available chair conformations.…
A: Explanation - A conformation in which both substituents are equatorial will always be more stable…
Q: The cyclohexane derivative shown exists primarily in the more stable of the two available chair…
A: Group a is at axial position. Group b is at equatorial position. Group c is at axial position.
Q: cis-2,5-dimethy-1,3-dioxane The structure of cis-2,5-dimethyl-1,3-dioxane is shown above, without…
A: A stable chair confirmation is the one where the bulky groups are in equatorial position.
Q: The cyclohexane derivative shown exists primarily in the more stable of the two available chair…
A: Chair conformation is most stable and groups are attached on respective equatorial and axial…
Q: 2) Draw Newman projections of all staggered conformations of (S)-butan-2-ol. Clearly mark the…
A: Introduction: The isomers which are formed by rotating along a single bond is called a…
Q: How many different stereosomers are there for 2-bromo-3-chloropentane? 3
A: Since you have posted multiple questions, we are entitled to answer the first only.
Q: (1) Provide clear drawings of both chair conformations of trans-3(tert- butyl)cyclohexan-1-ol. (6)…
A: (i) Given compound named trans-3-(tert-butyl) cyclohexan-1-ol , have two substituents at cyclohexane…
Q: Sight along the C2-C3 bond of 2, 3-dimethylbutane, and draw a Newman projection of the most stable…
A: Newman projection of the most stable conformation, along the C2-C3 bond of 2, 3-dimethylbutane is…
Q: Make a model of each compound, draw it in its most symmetric conformation, and determine whether it…
A: The structure of trans-1,3-dibromocyclohexane is given below.
Q: The cyclohexane derivative shown exists primarily in the more stable of the two available chair…
A: All the three groups are attached to the same face of the cyclohexane ring which means they are cis…
Q: Cyclohexane derivatives exist primarily in the most stable of the available chair conformations.…
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Q: Consider the structures of both cis- and trans-1-t-butyl-3-methylcyclohexane. Which of the four…
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Q: Between the cis and trans configuration of 1-chloro-3-methylcyclohexane, which is the most stable…
A: Groups which are axial in the chair form of cyclohexane derivatives cause instability in the…
Q: Which of the statements below correctly describes the chair conformations of cis-1,4-…
A: Note: In both chair conformations one ethyl at axial, one ethyl at equatorial. Therefore both chari…
Q: Given that the change in free energy between axial and equatorial chlorine is 0.52 kcal.mol-1 , what…
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Q: Following are the alternative chair conformations for trans-1,2-dimethylcyclohexane.(a) Estimate the…
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Q: 8. Predict the most stable conformation of each of the following molecules and explain the basis of…
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Q: 17. In the space provided below please draw (cis)1,3-dimethylcyclohexane in the most unstable chair…
A: Concept: 1) most unstable conformation meaning that the molecule will have higher energy & this…
Q: Draw 2 of the chair conformations for the compounds shown below and then cricle which are most…
A: Chair confirmation is one of the most stable conformation of the cyclohexane. In chair conformation…
Q: Cyclohexane derivatives exist primarily in the most stable of the available chair conformations.…
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Q: In an eclipsed conformation of the Newman projection, the dihedral angle, which is an angle between…
A: Ans
Q: How many gauche interactions are present in the most stable chair conformation of…
A: Two conformers can be drawn for 1,1,2-trimethyl cyclohexane. In one conformer, C-1 and C-2 methyl…
Q: 5. A saturated hydrocarbon is represented by a structural formula in which each C atom has degree 4…
A: The hydrocarbons are compounds containing only C and H atoms in the organic chain. Their are various…
Q: Make a model of each compound, draw it in its most symmetric conformation, and determine whether it…
A: A model of the given compound, its most symmetric conformation is drawn and optical activity of…
Q: Which cyclohexane chair, axial-methyl or equatorial-methy, is higher in energy and why? Draw the…
A: 1,3-Diaxial interaction is the repulsive interaction between an axial group and two axial groups or…
Q: The cyclohexane derivative shown exists primarily in the more stable of the two available chair…
A: In more stable cyclohexane chair conformation maximum groups are equatorial . Because at equatorial…
Q: 2. Draw the two chair conformations of 3-tert-utyl-1-methyleyclohexanol and estimate the amount of…
A: Given,
Q: Make a model of each compound, draw it in its most symmetric conformation, and determine whether it…
A: The given compound is 1-bromo-1-chloroethane.
Q: Cyclohexane derivatives exist primarily in the most stable of the available chair conformations.…
A: To tell the position of the groups , we would first draw a chair configuration of the given…
Q: 1. Draw the Newman projections for the three staggered conformations about the C3-C4 bond of the…
A: Conformers are the isomers which arises when spatial arrangement of atoms changed on single bond…
Q: Give a clear explanation handwritten answer..give the stereochemistry with most stable chair…
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Q: Draw the most stable chair conformation of the cis-1-Ethyl-2-methylcyclohexane and estimate the…
A: The two possible chair confirmation of cis-1-Ethyl-2-methylcyclohexane are as follows: Among the…
Q: Cyclohexane derivatives exist primarily in the most stable of the available chair conformations.…
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- Draw the structure of (Z) N-phenyl-2-fluoro-3-iodo-2-hexenamide. 2. Give the IUPAC name of this compound, including stereochemistry. &Ch,Ch, ÇH2CH; CH3- 3. Draw the most stable chair conformation of (trans) 1,4-cyclohexandiol.(c) Treatment of 4-tert-butylcyclohexanone with the unusual reducing agent magnesium hydride leads to the cyclohexanols 1 and 2 as shown below. Answer ALL parts (i) to (iii). НО.,,, 1. MgH₂, THF 2. HCI, H₂O + но, 2 minor product major product (i) Draw the lowest energy chair conformation of each of alcohols 1 and 2. (ii) Hence, explain which of the two compounds is lower in energy. (iii) As shown, isomer 2 is the major product. Explain how this result allows you to decide whether the reaction is under kinetic or thermodynamic control.2. Compound A, C;H100 , is one of the basic building blocks of nature. All steroids and many other naturally occuring compounds are built from compound A. Spectroscopic analysis of A yields the following information: IR: 3400 cm-'; 1640 cım- IH NMR: 1.63 & (3 H, singlet); 1.70 ô (3 H, singlet); 3.83 6 (1 H, broad singlet); 4.15 8 (2 H, doublet, j = 7 Hz); 5.70 ô (1 H, triplet, ) = 7 Hz) (a) How many double bonds and/or rings does A have? (b) From the IR spectrum, what is the identity of the oxygen-containing functional group? (c) What kinds of protons are responsible for the NMR absorptions listed ? (d) Propose a structure for A.
- Q1: Draw the structure of each of the following molecules: (a) (R)-1-chloro-1-fluorobutane (c) (2R,35)-3-Bromo-2-chloro-1-pentanol (4 (b) (S)-2-chloropentane; (d) (R)-2,2,3-trichlorobutane. utures Fxamples areIQ3 نقطة واحدة Name the following heterocyclic ethers (a) إجابتك نقطة واحدة Name the following heterocyclic ethers H. CH,CH3 (d) CH,CH, H. إجابتك نقطة واحدة Name the following heterocyclic ethers -CH3 CH; () Br إجابتك. II >1. Draw the structures of the following substituents and place them in descending order of priority. (a) Methyl, bromomethyl, trichloromethyl, ethyl; (b) 2-methyl-propyl (isobutyl), 1-methyl-ethyl (isopropyl),cyclohexyl; (c) butyl, 1-methyl-propyl (sec-butyl), 2-methyl-propyl (isobutyl), 1,1-dimethyl-ethyl (tert-butyl); (d) ethyl, 1-chloro-ethyl, 1-bromo-ethyl, 2-bromo-ethyl. 2. Check the absolute configuration of the items below: a) b) d) H "CH₂CH3 CH3 Br CH3 f F |||| H₂N- CH₂CH3 CH3 fr -COH H f) HC H- H Br HC. "ICH3 FCH₂ CH3 CH3 Br H
- Draw the organic product(s) of the following reaction. CH3 H3C-C-CEC-H CH3 NaOC2Hs / CH5OH 1 eq. NANH2, NH3(1) CH;CH,CH,CH2-Br H-CEC-H H;C CH-Br H3C 1 eq. NaNH2, NH3() H3C-CEC-H(a) 2-methyl-2-pentanol Draw the structure of the alkene that was used to prepare the alcohol in highest yield. ? ChemDoodle Which process does this employ? 1. Hg(OAc)2, H₂O; 2. NaBH4 1. BH3; 2. H₂O2, NaOH OsO4, H₂O2 √ [FComplete the following: Stereochemistry, enantio-, and regioselectivity are important. CrO3, H2SO4 a) OH Bromination of an alcohol (Sn2) type EtO₂C CO₂Et b) b) d) H3CO type NH2 a) b) H3CO type a) b) OH g) type CN CI h) acetone Swern Oxidation type type CO₂H type Доно i) Me3SICI, Imidazole OSiMe3 Et3N, CH2Cl2 Br type a) Mg°, THF Br j) b); H3O+ H2SO4 (H+) MeOH OMe type type
- (a) Provide the missing reagents and line structures of the products (C- E) for the following reactions. Include stereochemistry for products Cand E as indicated. No mechanisms are required. (5) C H,0 Show stereochemistry any one diastereomer OH PCC. CH;Cla D H. Pd/C Show stereochemistry any one enantlomer4G 4G 1:54 PM 43 ... H2NCH,CH,CHNH2 CH3 3. Draw structures corresponding to the following IUPAC names: (a) Triethylamine (b) N-Methylaniline (c) Tetraethylammonium bromide (e) N-Ethyl-N-methylcyclopentylamin (d) p-Bromoaniline1. Draw the structure of all reactants and product for the following reactions. (a) 2-methyl-1-iodocyclopentane + NaOCH3 ------>A (b) A + (1) Hg(OAc)2, H2O/(2) NaBH4 ------>