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Q: Name four downstream effects of p53 activation.
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Q: explain how p53 functions in a cell that sustained DNA damage to prevent progression of that cell…
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Q: is the p53 protein an activator or a repressor? How do you know?
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A: As with most body processes, the cell cycle is highly regulated to prevent mutated cell synthesis…
Q: Define Suppressor Mutations.
A: Suppressor mutations are helpful for distinguishing new genetic sites that have an effect on a…
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Q: How does p53 halt cell cycle progression when DNA damage is identified? p53 enhances expression of…
A: p53 protein is a transcription factor that regulates the expression of several genes which are…
Q: p53 can trigger apoptosis if certain cell-cycle events fail. How does this regulatory outcome…
A: Apoptosis is the programmed cell death. Apoptosis is one of the important events in development that…
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Q: why is it important for all somatic cells to be genetically identical?
A: Except for sperm and egg cells, a somatic cell is any cell in the body. Somatic cells are diploid,…
Q: When p53 is activated, a cell cannot progress: A. throught M-phase B. from G2 into M phase C. From…
A: The p53 protein acts as a tumor suppressor, which means that it regulates cell division by keeping…
Q: In chapter 8 we read that in tumor cells Rb protein is hyperphosphorylated. In response to that,…
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Q: // Which CDK and cyclin does p53 ultimately target in DNA damaged conditions? O CDK1/cyclin E O…
A: CDK phosphorylate soecific target proteins. They required cyclin to be activate. CDK-cyclin…
Q: Explain why p53 is mutated in the vast majority of human cancers.
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Q: Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras…
A:
Q: Are all pluripotent stem cells created equal, however?
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Q: If p63 can bind to the same promoter elements as p53, why would it be considered an inhibitor of…
A: Promoters are DNA sequences that function as a kind of "On" switch to start the biological process…
Q: You are analyzing the activity of the protein p53 in two different cell types. You notice that p53…
A: The function of a protein is primarily related to its structure if the composition of protein is…
Q: The p53 protein regulates the expression of BAX and Bcl2 to keep division at normal rate. Explain…
A: The p53 gene codes for p53 protein which regulates the expression of BAX and Bcl2 to keep cell…
Q: Which of the following can lead to p53 stabilization and activation? O Hypoxia
A: P53 is a tumour suppressor gene that plays an important role in controlling cell division and cell…
Q: When the DNA of a human cell becomes damaged, the p53 geneis activated. What is the general function…
A: p53 gene: Tumor protein p53 gene also p53 is a protein encoded by homologous genes in various…
Q: What is the rationale for synthesizing and rapidly degrading p53 protein in the cell?
A: P53 is a nuclear transcription factor with pro apoptotic function as 50% of human Kansas carries…
Q: List the regulatory mechanisms that might be lost in a cell producing faulty p53.
A: The cell cycle is the series of events that lead to the formation of new cells from the parent…
Q: does P53 It integrate together information from over a hundred proteins about the mutational state…
A: A gene that makes a protein that is found inside the nucleus of cells and plays a key role in…
Q: Explain DNA methylation. How does this process influence cellular function?
A: DNA methylation is a process in which Dna bases are Methylated with the help of enzyme Methyl…
Q: Which of the following statements correctly describes p53? Which of the following statements…
A: Answers are option B and E.
Q: what are the normal funtions of the p53 gene
A: p53 gene is also called as tumour suppressor gene or Tp53 gene produces the protein called tumour…
Q: Why is it advantageous for p53 to be activated by factors such as ER stress, light, and hypoxia (low…
A: The p53 is known as tumor protein formed from the TP53 gene. The protein acts as a tumor suppressor…
Q: What makes X inactivation an epigenetic phenotype?
A: In humans, there are 23 pairs of chromosomes in which the 23rd pair is the sex chromosome which…
Q: In tumor cells Rb protein is hyperphosphorylated. In response to that, will p53 level increase or…
A: Rb protein is a very powerful tumor suppressor protein it checks the cell cycle and when it's levels…
Q: Explain the theory of epigenesis
A: Developmental biology is the branch of biology that deals with the processes involved in the growth…
Q: As the most junior member of a lab, you are tasked with generating cell lines that accumulate DNA…
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Can you think of two ways in which the function of p53 can be disrupted?
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- If you were to design an experiment to get p53 back into cancer cells, how would you go about that work? How would you direct p53 into the nucleus of cancer cells without directing it to the nucleus of healthy cells? As an overabundance of p53 in healthy cells would cause problems. Could someone in depth answer these questions for me and explain them cellularly.What must occur for TP53 to no longer function properly?Name four downstream effects of p53 activation.
- The vast majority of human cancers mutations in the p53 gene. What is the function of p53 normally in the cell? What happens when p53 is mutated? Is this a gain of function or loss of function mutation?is the p53 protein an activator or a repressor? How do you know?The p53 pathway is important for regulating the cell cycle. In a normal cell, there is a protein called mdm2 that can bind to p53 and deactivate it. A diseased individual has amutation in the gene that codes for mdm2, resulting in an mdm2 protein that is less able to bind to p53. Will this mutation increase, decrease, or cause no change in the rate of cell death? Explain.
- // Which CDK and cyclin does p53 ultimately target in DNA damaged conditions? O CDK1/cyclin E O CDK2/cyclin E CDK1/cyclin B CDK2/cyclin BHow does p53 induce apoptosis? How does the cell determine what "too much" damage is? Meaning, how can it tell if the damage to the DNA is too severe to fix in order for the cell to move on to S phase? Thank you.In your own words, explain epigenetics. What is it? What are the main epigenetic marks? What do they do in terms of gene transcription? What are the enzymes involved?