Concerning the role of ILC3 in the crosstalk between cells at barrier site, identify the correct sequence of events? O Macrophages in the lamina propria sense the microbiota and produce IL-22 that binds to the IL-22 receptor on ILC3. Activated ILC3 produce mucins O Epithelial cells sense the microbiota and produce IL-1 that in turn activates ILC3 in the lamina propria to release IL-22. IL-22 induces synthesis of REG3 molecules and mucus production in epithelial cells O Epithelial cells and ILC3 do not respond to microbiota antigen. Only enteric infections cause release of cytokines, including IL-1. Inflammation ensues which results in IL-22 production that in turn induces the synthesis of pathogen-specific antimicrobial peptides O All options are possible O Specific recognition of microbiota antigens by ILC3 induces their activation and release of cytokines including IL-1 and IL-22. IL-1 and IL-22 induce plasma cell differentiation and IgA release by epithelial cells

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question 29
Concerning the role of ILC3 in the crosstalk between cells at barrier site, identify the correct sequence of events?
O Macrophages in the lamina propria sense the microbiota and produce IL-22 that binds to the IL-22 receptor on ILC3. Activated ILC3 produce mucins
O Epithelial cells sense the microbiota and produce IL-1 that in turn activates ILC3 in the lamina propria to release IL-22. IL-22 induces synthesis of REG3 molecules and mucus
production in epithelial cells
O Epithelial cells and ILC3 do not respond to microbiota antigen. Only enteric infections cause release of cytokines, including IL-1. Inflammation ensues which results in IL-22
production that in turn induces the synthesis of pathogen-specific antimicrobial peptides
O All options are possible
Specific recognition of microbiota antigens by ILC3 induces their activation and release of cytokines including IL-1 and IL-22. IL-1 and IL-22 induce plasma cell differentiation and
IgA release by epithelial cells
Transcribed Image Text:Question 29 Concerning the role of ILC3 in the crosstalk between cells at barrier site, identify the correct sequence of events? O Macrophages in the lamina propria sense the microbiota and produce IL-22 that binds to the IL-22 receptor on ILC3. Activated ILC3 produce mucins O Epithelial cells sense the microbiota and produce IL-1 that in turn activates ILC3 in the lamina propria to release IL-22. IL-22 induces synthesis of REG3 molecules and mucus production in epithelial cells O Epithelial cells and ILC3 do not respond to microbiota antigen. Only enteric infections cause release of cytokines, including IL-1. Inflammation ensues which results in IL-22 production that in turn induces the synthesis of pathogen-specific antimicrobial peptides O All options are possible Specific recognition of microbiota antigens by ILC3 induces their activation and release of cytokines including IL-1 and IL-22. IL-1 and IL-22 induce plasma cell differentiation and IgA release by epithelial cells
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