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What is an example of a diagram that explains the core concept of flow down gradients in the urinary system/kidneys?
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- Which of the following does not contribute to the high salt concentration in the interstitial fluid of the kidney medulla? (a) active transport of sodium from the upper part of the ascending limb (b) diffusion of salt from the ascending limb of the loop of Henle (c) reabsorption of salt from various regions of Bowmans capsule (d) counterflow of fluid through the two limbs of the loop of Henle (e) diffusion of urea out of the collecting ductDraw a schematic diagram showing the flow of water and salts in the proximal tubule of the kidney. In this diagram, put the lumen on the left side of the diagram and the extracellular fluids on the right side of the diagram. Indicate where the lumen is, where the extracellular fluid is, where the apical portion of the cell is, and show the location of the proteins that are responsible for the movement of water and salts and glucose reabsorption in this area of the kidneyThe renal handling of a novel drug is being studied. When the drug is present in the blood, it is filtered into the Bowman’s capsule and secreted via transport proteins in the renal tubules, but it is NOT reabsorbed. The lines on the following graph represent filtration, secretion and excretion rates of this drug at various plasma concentrations. For the three lines shown (labeled A-C) identify which line represents filtration, which line represents secretion, and which line represents excretion Explain how you determined this.
- Drugs that increase urine flow (diuretic drugs) are often employed in the treatment of hypertension (high blood pressure) or other disease states. Three physiological categories of such drugs are ones that (i) function as loop diuretics, (ii) inhibit the action of aldosterone, and (iii) block Na+ channels in the collecting ducts. Explain why each of these categories would be expected to increase Na+ excretion and urine flow.Pressure in the renal artery is 100 mm Hg and the pressure in the renal vein is 50 mm Hg. The resistance of the afferent arteriole equals 0.5 mm Hg•min/L and the resistance of the efferent arteriole equals 0.5 mm Hg•min/L. What is the pressure in the glomerulus?Glomerular filtration is affected by forces that oppose and promote filtration. What are these forces and explain the theory behind net filtration pressure?
- What are the two intrinsic mechanisms that provide auto regulation of glomerular filtrate? Explain any one of these.Explain the concept of a countercurrent multiplier system and how it works in the kidneys. What is the importance of this system to the function of the kidneys?Why is this statement false? Without the renal medullar osmotic gradient, you would not be able to raise the concentration of urine above 1200 mOsm
