Can you help me? 13.11) Draw the structural formula for the predominant form of Asp-Gly-Lys-Ala at physiological pH. Lone pairs are optional.HLH-N-C|HH:0:||CH₂C-Ö:||:0:aspartic acidH H :0:| ||C-O:H-N-C-1HHglycineHLH-NHH:0::0:||L ||c-c-Ö: H-NC-C-O:CH3HCH₂TCH₂TCH₂CH₂H-N-HHlysineIHHalanineHINT:Peptides are often identified by listing its aminoacid residues' three-letter abbreviations inorder from N-terminus to C-terminus.To begin, draw the four amino acids side-by-side(as shown on the right) and then connect them inthe same manner that was used for the dipeptidein problem 13.7Because the structures in your table of aminoacids are the predominant forms atphysiological pH, if you correctly connectthe amino acid structures from the amino acidtable, then the peptide that you draw will bethe predominant form at physiological pH.

Amino acid sequences are written with N-terminal amino acid on the left and C-terminal amino acid on…

Answered: Draw the structural formula for the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Identify the structure of the predominant form of the pentapeptide at pH = 12 if there is a pentapeptide Ile-Lys-Asp-Phe-Gly
The melanocyte-stimulating peptide hormone a-melanotropin has the following sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val (a) Write the sequence using the one-letter abbreviations. (b) Calculate the molecular weight of a-melanotropin, a da'
Hydrolysis of dodecapeptide P with the enzyme trypsin affords the following fragments: Arg, Ser-Tyr-Ser-Met-Lys, Ala-Gly-Asp-Phe-Glu-Arg. Hydrolysis with chymotrypsin yields: Glu-Arg, Arg-Ser-Tyr, Ser-Met-Lys-Ala-Gly-Asp- Phe. What is the amino acid sequence of P? Submit Answer Retry Entire Group 9 more group attempts remaining
The melanocyte-stimulating peptide hormone a-melanotropin has the following sequence:Ser–Tyr–Ser–Met–Glu–His–Phe–Arg–Trp–Gly–Lys–Pro–Val(a) Write the sequence using the one-letter abbreviations.(b) Calculate the molecular weight of a-melanotropin, using data inTable
The key reaction steps in the Edman degradation of polypeptides, which removes the N-terminal amino acid in the form of a "phenylthiohydantoin" (PTH-amino acid), are shown below. What is the expected outcome if the N-terminal amino acid is proline (Pro)? (The structure of proline is provided below for your reference.) NH-C00 NH CO0 phenyl isothiocyanate PITC NH CO0 NH CO0 peptide without the thiszolinone original Nterminal amino acid HE a PTH-amino acid Proline: HN HN. O Edman's reagent will not react with an N-terminal proline.
Identify the structure of O-a-D-sorbopyranosyl-(24)-B-D-glucopyranose below. The following structures will help: НО Н ОН х Н H H D-sorbose Н OH CH₂OH Н Н Н OH HO Н H HO H н HO ОН Н н Н О ОН O H Н CH₂OH OH OH н 0 CH2OH Н OH Н H OH Н CH₂OH H ОН Н OH Н Н Н РО OH Н HO OH н н -O CH2O Н O H H OH н Н OH CH₂OH о CHOH H H Н Ко OH H OH Н Н OH Н OH Н OH Н CH₂OH -OCHOH H OH O CH OH Н OH Н Н CH₂OH ОН он OH OH H OH H O OH CH₂OH OH ОН Н O OH OH D-glucose Н ОН Н ОН ОН
1. Draw the condensed structural formulas for A and B. [0] [0] CH, CH, CH-CH, C-OH А B 2. Identify the type of glycosidic bond that links the monosaccharides and the structure of the disaccharide as a- or 8-isomer. CH-OH H. H OH H. CH, HO OH H. H. ОН Н OH HO H. OH A,
gal(a1–6)gal(a1–→6)glc(a1→2B)fru. Which of the complete IUPAC of this tetrasaccharide? O a-D-galactopyranosyl-(1-6)- a-D-galactopyranosyl-(1-6)- a-D-glucopyranosyl-(1+→2)-B-fructofuranoside O a-D-galactopyranosyl-(1-6)-B-D-galactopyranosyl-(1→6)- a-D-glucopyranosyl-(1+2)-B-fructofuranose O a-D-galactopyranosyl-(1–6)- a-D-galactopyranosyl-(1–6)- a-D-glucopyranosyl-(1+→2)-B-fructofuranose a-D-galactopyranosyl-(1-6)-B-D-galactopyranosyl-(1→6)- a-D-glucopyranosyl-(1+2)-B-fructofuranoside
Given the following peptides below, what would be more soluble at the indicated pH? 1. (Gly)20 or (Glu)20 in pH 7.0 2. (Lys-Ala)3 or (Phe-Met)3 in pH 7.0 3. (Gly)20 or (Glu)20 in pH 6.0|| 4. (Ala-Ser-Gly)s or (Asn-Ser-His)s in pH 6.0 5. (Ala-Asp-Gly)8 or (Asn-Ser-His)8 in pH 3.0
An oligopeptide has the following amino acid sequence: NH2-Ala-Glu–Leu–Trp–Tyr-Ser–Gly–Lys–Leu-Ala–Arg-Ala-Phe-Ile-Pro–Gly-COOH a) Estimate the net electric charge of the molecule at pH 8.0 and pH 11.0. b) If the above peptide is passed through a cation exchange chromatographic column (that is, the matrix of the column has negative charges) stabilized at pH 8.0, would you expect it to be retained on the column? c) Indicates the number of fragments, and the sequence of each of them, that would be obtained when treating the peptide in question with: i) trypsin, ii) chymotrypsin.
Based on the following titration table of Glycine, would you be able to recreate the same for Histidine? Glicina Increasing pH H-N-CH,-COOH -H-N-CH,-co = H-N-CH,-C00- Net charge: +1 pH COOH-pKa = 2.3 NH3-pka = 9.6 CN AEq +1 +1 2.3 (0.5°-1)+(0.5°0)=-0.5 +0.5 0.5 9.6 -1 (0.5*+1)+(0.5°0)=+0.5 -0.5 1.5 14 Given that the pKas for Histidine are the following: pka1 = 1.82 pKa2 = 9.17 pКаз %3 6.00 pL = 7.59 2.
Draw the structure of the pentapeptide Gln-Trp-His-Glu-Tyr that would predominate in acqueous solution at pH=10.3. (Relevant pKa values are: 2.2,4.3,6.0,9.8 and 10.1)

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