For the amino acid alanine, the major species in solution at pH 7 is the zwitterionic form, which has a negatively charged carboxylic acid group and a positively charged amino group. There is a less common neutral form in which neither group is charged. The carboxylic acid group of alanine has a pK₁ of 3. The amino group of alanine has a pK₁ of 8. Estimate the ratio of the concentration of the neutral amino acid species to the zwitterionic species at pH 7.

For the amino acid alanine, the major species in solution at pH 7 is the zwitterionic form, which has a negatively charged carboxylic acid group and a positively charged amino group. There is a less common neutral form in which neither group is charged. The carboxylic acid group of alanine has a pK₁ of 3. The amino group of alanine has a pK₁ of 8. Estimate the ratio of the concentration of the neutral amino acid species to the zwitterionic species at pH 7.

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter22: Proteins

Section: Chapter Questions

Problem 22.49P: 22-49 Based on your knowledge of the chemical properties of amino acid side chains, suggest a...

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