- For the following reactions, it was found that the diastereoselectivity decreased with the protecting group changed from methyl ether to a trimethylsilył ether and the results was summarized in the following. Please explain these observations. (10%) MezMg Me он Me. OH Me Me Me Ph THF. -70 "C Ph Ph ÖR OR ÖR R Ratio Relative rate Me >99:1 1000 SiMes 99:1 100 SiEt3 99:6 8 SiMezt-Bu 88:2 2.5 SiPhzl-Bu 63:37 0.82 Si(i-Pr)s 42:58 0.45

- For the following reactions, it was found that the diastereoselectivity decreased with the protecting group changed from methyl ether to a trimethylsilył ether and the results was summarized in the following. Please explain these observations. (10%) MezMg Me он Me. OH Me Me Me Ph THF. -70 "C Ph Ph ÖR OR ÖR R Ratio Relative rate Me >99:1 1000 SiMes 99:1 100 SiEt3 99:6 8 SiMezt-Bu 88:2 2.5 SiPhzl-Bu 63:37 0.82 Si(i-Pr)s 42:58 0.45

Fundamentals Of Analytical Chemistry

9th Edition

ISBN:9781285640686

Author:Skoog

Publisher:Skoog

Chapter7: Statistical Data Treatment And Evaluation

Section: Chapter Questions

Problem 7.9QAP

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