do you have any clues?GAP protein helps hydrolyze the GTP to GDP in RAS protein. Argenine 789 residue in GAP protein interacts with GTP in RAS protein. However, Arg 789 is mutated to Alanine. which are true or false? ____We expect Ala789 GAP to have no consequence for cell growth or survival signaling.____Arg789 stabilizes the T-loop of GAP in the outward (active) position, so we expect Ala789 GAP to have no kinase activity.___Arg789 participates in the GTP hydrolysis reaction carried out by RAS, so we expect RAS to be catalytically inactive when partnered with Ala789 GAP.____Arg789 binds in the major groove of the DNA double helix, so we expect Ala789 GAP to be inactive as a transcriptional regulator.__Arg789 interacts with RAS switch 1 and switch 2 regions, so we expect the RAS switch to fail with Ala789 GAP.____The RAS switch would be locked in the OFF position by Ala789 GAP, so we expect no constitutive RAS signaling and hence no risk of this tumor metastasizing.____The RAS switch would be locked in the ON position by Ala789 GAP, so we expect that small molecule inhibitors of RAF or MEK might slow cancer cell division although they would probably not kill the cancer cells.____Arg789 of GAP is critical for the GAP and checkpoint 2 kinase interaction that prevents entry into S phase if damaged DNA is detected, so we expect Ala789 GAP to facilitate replication of damaged DNA.___The RAS switch would be locked in the ON position by Ala789 GAP, so we expect that small molecule inhibitors of epidermal growth factor receptor (EGFR) would block signals from this RTK to RAS and slow cancer cell division.____An amino acid change from Arg789 to Ala789 might generate a novel peptide that T lymphocytes could detect in a cancer therapy involving immune checkpoint blockade.

Answered: GAP protein helps hydrolyze the GTP to…

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 2VCQ: Figure 9.10 In certain cancers, the GTPase activity of the RAS G-protein is inhibited. This means...

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GAP protein helps hydrolyze the GTP to GDP in RAS protein. Argenine 789 residue in GAP protein interacts with GTP in RAS protein. However, Arg 789 is mutated to Alanine. which are true or false?

____We expect Ala789 GAP to have no consequence for cell growth or survival signaling.
____Arg789 stabilizes the T-loop of GAP in the outward (active) position, so we expect Ala789 GAP to have no kinase activity.
___Arg789 participates in the GTP hydrolysis reaction carried out by RAS, so we expect RAS to be catalytically inactive when partnered with Ala789 GAP.
____Arg789 binds in the major groove of the DNA double helix, so we expect Ala789 GAP to be inactive as a transcriptional regulator.
__Arg789 interacts with RAS switch 1 and switch 2 regions, so we expect the RAS switch to fail with Ala789 GAP.
____The RAS switch would be locked in the OFF position by Ala789 GAP, so we expect no constitutive RAS signaling and hence no risk of this tumor metastasizing.
____The RAS switch would be locked in the ON position by Ala789 GAP, so we expect that small molecule inhibitors of RAF or MEK might slow cancer cell division although they would probably not kill the cancer cells.
____Arg789 of GAP is critical for the GAP and checkpoint 2 kinase interaction that prevents entry into S phase if damaged DNA is detected, so we expect Ala789 GAP to facilitate replication of damaged DNA.
___The RAS switch would be locked in the ON position by Ala789 GAP, so we expect that small molecule inhibitors of epidermal growth factor receptor (EGFR) would block signals from this RTK to RAS and slow cancer cell division.
____An amino acid change from Arg789 to Ala789 might generate a novel peptide that T lymphocytes could detect in a cancer therapy involving immune checkpoint blockade.

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