Give the disadvantages of using cisplatin as an anti-cancer drug and give examples of how newer platinum-based drugs attempt to overcome these disadvantages.
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- Detail of basic steps involved in synthesis of a recombinant drug product. Justify by manufacturing protocol of recombinant insulin.Describe one chemotherapeutic approach that can be used to treat prostate cancer? Your answer should include information about the molecular processes and interactions which are at the core of the treatment strategyQ2) А. As long as the optimum dosage of the ionizing radiation is achieved it can be used for treatment of cancer. Can you explain the working principle of the treatment? - Hint: Consider the effect of treatment on both healthy and cancer cells В. Please explain how DNA viruses and telomere shortening may cause the onset of cancer.
- Heterotypic interactions of tumor cells have been a fertile area for potential therapeutic interventions. Find a specific example of a drug/therapy that targets these interactions and explain the mechanism by which it treats cancer.Induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Please provide information on induced pluripotent stem cells and their use as described above (model various diseases and screen drugs in these in vitro models). Please explain clearly and nicely. THANKSWhy Nutlin may represent a potential anti-cancer drug?
- Drug 2-Lumacaftor (VX-809): In people with the most common CF mutation, F508del, a series of problems prevents the CFTR protein from folding into the correct shape and reaching its proper place on the cell surface. The cell recognizes the protein as abnormal and targets it for degradation before it makes it to the cell surface. In order to treat this problem, two drugs are required - an agent to get the protein to the surface and then Ivacaftor to open the channel and increase chloride transport. The drug Lumacaftor has been identified as a treatment to help with the trafficking of the protein to the cell surface. When Lumacaftor is added to Ivacaftor, the protein gets to the surface and also increases chloride transport by increasing channel opening time. For which class(es) of mutations would Lumacaftor be most effective?Why clinical trials are necessary? Explain various clinical trial designs and phases of clinical trials.Please verify if correct or not. If incorrect, please match descriptions with the correct mutation.
- Question:- How is the assembly of an antibody different than traditional forms of alternate splicing?Critically discuss the following statement: ‘The success of PARP inhibitor therapy in ovarian cancer has led to the development of novel synthetic lethal strategies targeting DNA damage response in solid tumours’. Include challenges of PARP inhibition therapy as well as future developments in your answer.Why is it important to model cancer through the generation of induced pluripotent stem cells ? Explain in detail the main findings.