Given the active site and reaction mechanism below, what is the mechanism of irreversible inhibition of the inhibitor provided? Active Site Reaction Mechanism HN HO You OH NH₂ 20.PO HO HO HO OH. H₂N 20.,PO HO HO HO OH HO H₂N® 20.po HO HO HO OH Inhibitor 2-0,PO HO HO HO OH

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter1: Relative Value, Addition, And Subtraction Of Decimals
Section: Chapter Questions
Problem 6.1P
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Question
Given the active site and reaction mechanism
below, what is the mechanism of irreversible
inhibition of the inhibitor provided?
Active Site
Reaction Mechanism
HN
20,PO
20 PO
HO
HO
YO+ OH
H₂N®
NH₂
20.PO
HO
HO
-O
HO OH
H₂N
HO
HO OH
HO
20.PO
HO
HO
HO OH
Inhibitor
20.PO
HO
HO
HO OH
Transcribed Image Text:Given the active site and reaction mechanism below, what is the mechanism of irreversible inhibition of the inhibitor provided? Active Site Reaction Mechanism HN 20,PO 20 PO HO HO YO+ OH H₂N® NH₂ 20.PO HO HO -O HO OH H₂N HO HO OH HO 20.PO HO HO HO OH Inhibitor 20.PO HO HO HO OH
○ Transition state analog
Uncompetitive
Mechanism-based
Affinity-based
O Non-specific
Transcribed Image Text:○ Transition state analog Uncompetitive Mechanism-based Affinity-based O Non-specific
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