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An anti-inflammatory drug has a total body clearance (ClT) of 65 mL/min and is 70 % bioavailable after oral administration. If the drug is to be given orally every 8 hours, then what would be the maintenance dose (D) to achieve an average plasma concentration (Css,av) of 20 mcg/mL?
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- Nizatidine injection (25 mg/mL) is supplied in 4-mL vials. The prescription states that for continuous infusion 'dilute 300 mg in 150 mL and give at a rate of 10 mg/hour'. If this procedure is adopted, calculate: (a) how many vials of nizatidine injection will be required (b) the flow rate (in mg/hour). NOTE: PLEASE GIVE THE ANSWER WITHIN 2 HOURS THANK YOU200 mg of drug is given IV, plasma drug concentration is 70 mg/L. Calculate the Vd? Where most of the drug is distributed to? Note: Volume of Distribution (L) = Amount of drug in the body (mg) / Plasma concentration of drug (mg/L). O a. Vd=14000 L, drug is mostly outside of plasma, distributed to tissues O b. Vd=2.8 L, drug is mostly outside of plasma, distributed to tissues OC. Vd =0.35 L, drug is mostly in plasma Od. Vd=2.8 L, drug is mostly in plasma O e. Vd =0.35 L, drug is mostly outside of plasma, distributed to tissuesThe order is for 980 mL of D2.5W (2.5% dextrose in water) to infuse intravenously over a period of 8 hours (the drop factor is 20 gtt per mL). After the infusion has been running for 5 hours, you find 640 mL remaining left to be infused. What should the adjusted flow rate (in gtt/min) be in order to complete the infusion on schedule (i.e. within 8 hours)?
- 4) Identify three positions of the patient to obtain a BP. 7) What problems can result from high blood pressure Or (HYPERTENSION)? 9) What IS the effect of exercise on BP? How does the body benefit from this change in BP during exercise? 10) How would the BP of an anxious patient visiting a doctor be different than if the patient is calm? 11) In atherosclerosis, plaque builds up inside the arteries. How would this affect BP? Is this an example of hypertension or hypotension? Heart, artery, red blood cell, ventricle, capillary, plasma, vein, white blood cell, platelets (a) Which of these structures (i) Can destroy bacteria?................................................................................. (ii) Carries carbon dioxide. .................................................................................. (iii) Pumps blood around the body?..................................................................... (iv) Carries blood to organs.…Which of the following findings is the best indication that fluid replacement for a client with hypovolemic shock is adequate? Question 9 options: a) Respiratory rate of 24 breaths/minute b) Urine output greater than 30 ml/hr c) Diastolic blood pressure greater than 90 mmHg d) Systolic blood pressure less than 100 mmHgA client in the intensive care unit has a blood pressure of 87/39 mmHg with a bounding pulse and has warm, flushed skin accompanied by a sudden decline in level of consciousness. The client also has arterial and venous dilation and a decrease in systemic vascular resistance. Their body temperature is 39°C. What is the client's most likely diagnosis? Question 10 options: a) Septic shock b) Obstructive shock c) Neurogenic shock d) Hypovolemic shock
- if lincomycin was ordered to be infused QID along side an infusion of D5W; what would be the drops per minute infused for the D5W if the total infusion ordered is 2,000 mL over 24 hours? *A patient on your ward is in status epilepticus. The consultant has told his junior doctor to prescribe a loading dose of phenytoin, please help calculate the dose.The patient is an adult female weighing 50kg1) Calculate the intravenous loading dose for phenytoin.(show working) 2) what diluent/infusion fluid should the doctor use when making up the infusion?3) What volume of infusion fluid should he use and what rate should he run this at?4) Is there any monitoring required whilst the patient is receiving this infusion?5) Look at your BNFs to see what other drugs are commonly used to treat status epilepticus.https://www.youtube.com/watch?v=t0IngUYN2OA https://www.youtube.com/watch?v=pPxnIh_WTb8 1) Identify three positions of the patient to obtain a BP. 2) What problems can result from high blood pressure Or (HYPERTENSION)? 3) What problems can result from low blood pressure OR (HYPOTENSION)? 4) What IS the effect of exercise on BP? How does the body benefit from this change in BP during exercise? 5) How would the BP of an anxious patient visiting a doctor be different than if the patient is calm? 6) In atherosclerosis, plaque builds up inside the arteries. How would this affect BP? Is this an example of hypertension or hypotension? Part 2: The circulatory system has 5 functions. · Highlight the statements below that are only functions of the circulatory system. It carries cells that help to fight diseases. It gives structure and support to the body. It carries waste products to the urinary system. It carries carbon dioxide from cells…
- Newer clinical guidelines suggest using a cut-point value of 120 mmHg for systolic blood pressure to identify a person as being hypertensive. However, some clinicians and researchers have suggested increasing the cut-point value for systolic blood pressure to 130 mmHg to identify hypertension (i.e., those with systolic blood pressure of 130 mmHg and above would be positive for hypertension). If the cut-point value for identifying a person as hypertensive was increased from 120 mmHg to 130 mmHg, which of the following may occur? A. The sensitivity of the new cut-point value would increase. B. The specificity of the new cut-point value would increase. C. Both the sensitivity and specificity of the new cut-point value would increase. D. There would be no change to the sensitivity or specificity of the new cut-point value.1) Please answer the following regarding Cardiovascular Drugs. A) What are the difference between the hypertensive drugs and list the drug corresponding to each category:1. Beta Blockers, 2.Calcium Channel Blockers, 3.Ace Inhibitor,4. Angiotensin II Blockers, 5. Diuretics. B) What are the difference between the cholesterol Lowering Agents and List the drugs corresponding to each category.Calculate drug clearance in the figure below assuming that drug dose was 4000 mg: 1000 y 400e0916 100 10 05 (25 Time thours) Plasma concentr ation (me/L)
