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How does the dysregulation of cell cycle checkpoints contribute to the development of cancer?
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- What would be the effect of a mutation that inactivates the p14ARF tumor suppressor upon p53 functions?What role do tumor suppressors, including p53, play in mediating cell cycle arrest for cells with DNA damage?What properties are gained during tumor progression that contribute to malignant behavior and metastasis?
- How can a defect in p53 gene contribute to cancer development?In order for certain cancers to propagate, they require a growth factor known as Vascular Endothelial Growth Factor (VEGF). What does VEGF signal the cell to do and how does this promote the propagation of cancer cells?Which component of cell division machinery is frequently targeted by anti-cancer drugs? Can you explain the common side-effects of chemotherapy (e.g. hair loss, mucositis) based on this information?
- What are the normal functions of the BRCA1 tumor suppressor gene?Why is p53 considered a tumor suppressor protein? Question 12 options: a) Because p53 normally detects breaks in DNA. b) Because p53 normally causes progression from G1 to S phase to halt until damaged DNA is fully repaired. c) Because p53 normally repairs breaks in DNA. d) Because p53 normally stimulates transcription of Repair Polymerase. e) Because p53 normally reduces the mutation rate of DNA polymerase.What is Cancer Epigenetics ?