In early 1960s, the National Cancer Institute was able to isolate a complex organic compound from the bark of the Pacific Yew, Taxus brevifolia. The structure of the cancer-fighting component of yew bark was determined in 1962, and the compound was names paclitaxel (Taxol). Taxol is an anticancer agent active against ovarian, breast, and some lung tumors. Given the structure of Taxol, identify and place an asterisk at the stereogenic or chirality centers present within its complex structures. (Hint: There are only 11 chirality centers). NH O OH Paclitaxel (Taxol) HO H OH
In early 1960s, the National Cancer Institute was able to isolate a complex organic compound from the bark of the Pacific Yew, Taxus brevifolia. The structure of the cancer-fighting component of yew bark was determined in 1962, and the compound was names paclitaxel (Taxol). Taxol is an anticancer agent active against ovarian, breast, and some lung tumors. Given the structure of Taxol, identify and place an asterisk at the stereogenic or chirality centers present within its complex structures. (Hint: There are only 11 chirality centers). NH O OH Paclitaxel (Taxol) HO H OH
Chapter27: Biomolecules: Lipids
Section27.SE: Something Extra
Problem 44AP
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