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Methylation, SNP array and clinical dataset for ovarian cancer beside TCGA?
Databases are the most advanced development post the sequencing of Human Genome which shifted the focus towards data creation, curation, validation and storage for public access to all the researchers across the globe in an open access forum or website to further research investigation.
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- Question : Give an alternative form of CpG methylation, given clear handwritten explaination!Part 3C: Below is data from a pedigree trace of patients affected with mouse model of pancreatic cancer, and below are the observations regarding a new gene called 318 that is found on chromosome 5. Patient II-4 has two copies of loss of function variant alleles (or is homozygous for loss-of-function variant 318 allele). Patient I-2 has one copy of loss of function variant and one copy of unaffected allele (is heterozygous for loss-of-function variant 318 allele). Patient II-1 has two copies of unaffected allele (or is homozygous for unaffected 318 allele). |-1 1-2 Il-1 Il-2 Il-3 |l-4 II-5 II-1 III-2 III-3 Based upon data above, what is the mode of inheritance for mouse model for pancreatic cancer? Why?Hi, can you elaborate about the following: certain characterize mutations in p63 and compare that to known mutations in p53.
- THE CHROMOSOMAL INSTABILITY PATHWAYS IN COLON CANCER Provide exmaples of genes give evidenceSevere adverse effect of Tocilizumab and Dexamethasone in COVID19 ?Below is a figure (here called Figure 1) from “Prognostic Significance of CpG Island Methylator Phenotype and Microsatellite Instability in Gastric Carcinoma,” by An et al., published in Clinical Cancer Research in 2005. The authors look at five microsatellite loci (BAT 25, BAT 26, D2S123, D5S346, and D17S250) in normal (N) and tumor (T) tissue from patients with Gastric Carcinoma. They amplify the loci by PCR and then instead of using standard agarose gel electrophoresis, they run the PCR products through capillary gel electrophoresis and detect bands as they pass a laser near the positive charge terminal. The x-axis in these plots is the time at which the band passed the laser (aka size of the PCR product) and the intensity of the peaks represents the amount of DNA in that band A. Which patient- 18, 30, or 1- shows the most microsatellite instability? Which patient shows the least? How do you know? B. In which repair pathway is it most likely that you will find the driver mutations…
- Skin cancer carries a lifetime risk nearly equal to that of allother cancers combined. Following is a graph [modified fromK. H. Kraemer (1997). Proc. Natl. Acad. Sci. (USA) 94:11–14]depicting the age of onset of skin cancers in patients with orwithout XP, where the cumulative percentage of skin cancer is plotted against age. The non-XP curve is based on 29,757 cancerssurveyed by the National Cancer Institute, and the curverepresenting those with XP is based on 63 skin cancers from theXeroderma Pigmentosum Registry.F. Written Response 1. If gene transcription is inhibited after fertilization, development past the two-cell stage does not take place in the mouse. However, in frog embryos, this treatment does not disrupt development until late cleavage. Explain this difference. 2. Twist transcription factors (TF) play key roles in embryonic development and are largely undetectable in normal adult tissues; however, their expression is reactivated during tumor progression and correlates with invasive and metastatic lesions. Transcription of the Twist gene is activated by Wnt signals and the Twist TF represses the gene for E-cadherin. Answer the following questions as briefly as possible, based on what was presented in class, not an internet search (complex answers that go beyond class material may lose points) a. Outline the steps from the Wnt signal to the E-cadherin gene (inclusive); e.g., A → B → C (with some clarifications such as "binds to", "activates", "represses") b. What are the normal…Describe the nature of p53 reactivation as acancer-fighting strategy
- Question: Explain how epigenetic marks and genomic imprinting are related. Provide a drawing to illustrate your point.expand this into 1000 words. the context is Identification of Differentially Expressed Genes in Breast Cancer Using RNA-Seq "In investigating the impact of TONSL overexpression on cellular physiology and gene regulation, differential expression analysis emerges as a pivotal analytical approach. By comparing gene expression profiles between primary cells and TONSL-overexpressing cells, researchers can identify genes whose expression levels are significantly altered. This analysis not only sheds light on the direct targets of TONSL but also unveils broader regulatory networks and pathways influenced by TONSL overexpression. Moreover, by pinpointing key genes involved, researchers can discern potential molecular mechanisms underlying the observed phenotypic changes associated with TONSL overexpression, offering valuable insights into TONSL's role in cellular homeostasis and function. Furthermore, functional enrichment analysis stands as a complementary approach to understanding the…be performed and used to determine the accuracy, sensitivity and specificity of the device. Using your own hypothetical values, calculate the accuracy, sensitivity and specificity of the device. Is the device suitable for screening for breast cancer, based on your calculated values of its accuracy, sensitivity and specificity? Explain.