Moxisylyte, an a-adrenergic blocker, is used as a peripheral vasodilator. Propose a syn- thesis for this compound from thymol, which occurs in the volatile oils of members of the thyme family. Thymol is made industrially from m-cresol. NMe, OH Moxisylyte Thymol m-Cresol
Q: Although ibuprofen is sold as a racemic mixture, only the S enantiomer acts as an analgesic. In the…
A: Since in the tautomerization reaction, the double bonded O will first take the proton from the HA…
Q: A mixture containing compounds A and B in methylene chloride (CH2C12) was extracted in a separatory…
A:
Q: Q1. Discuss the role of the following reagents in the extraction of caffeine. a. Vinegar b. Baking…
A: As per the rule, only one question can be answered.
Q: Preparation of Benzyl Alcohol by Hydrogenation of Benzoic Acid Catalyzed by a Magnesium Oxide-…
A: Preparation of benzyl alcohol by hydrogenation of benzoic acid catalysed by a magnesium…
Q: Propose a mechanism for formation of 2-carbethoxy-4-butanolactone and 4-butanolactone…
A: 2-carbethoxy-4-butanolactone
Q: Propose a mechanism for the hydrolysis of N,N-dimethylacetamide b) under acidic conditions.
A: The mechanism of acidic hydrolysis of an amide comprises two stages. The first half is an acid…
Q: Write the product that would result after subjecting benzylamine (PHCH2NH2) to the following…
A: The question is based on the concept of organic reactions. we have to identify the Product formed…
Q: The 1H NMR spectra for two esters with molecular formula C8H8O2 are shown next. Which of the esters…
A:
Q: Propose a mechanism for the hydrolysis of N,N-dimethylacetamide(a) under basic conditions
A:
Q: Show how you would convert propan-1-ol to the following compounds using tosylateintermediates. You…
A: One of the methods of amination of an alcohol involves the conversion of an alcohol to the tosylate…
Q: Addition of one mole of HCl to isoprene gives 4-chloro-2-methyl-2-butene as the major product.…
A: The reaction between isoprene and HCl is an addition reaction. The mechanism has been discussed…
Q: Phenacetin has the structure shown. Write an equation for its preparation, starting from 4-…
A:
Q: trans-stilbene trans-stilbene 2-bromo-1,2-diphenylethanol (a bromohydrin) Br 24 OH B. NBS C.DMSO…
A: A question based on introduction to organic chemistry that is to be accomplished.
Q: 11. two moles of ethyl phenylacetate undergo condensation to give a beta-keto ester. 12. a…
A: We have to write the structures of the following reactions 11. two moles of ethyl phenylacetate…
Q: Reflux 150°C-160°C NH2 NH2 HO 1 hour NH2 H20 H20 o-phenylene diamine formic acid benzimidazole
A:
Q: it is a water instable compound produced as injectable powder for instant reconstitution used to…
A: Deferoxamine, is also called as desferrioxamine. This medication binds iron and aluminum. Brand…
Q: 2 Draw structures to correspond with the following common and systematic names:(a) phenyl formate…
A: a).The given compound is phenyl formate. The molecular formula of phenyl formate is C7O2H6. The…
Q: но- OH + HO-CH3 но -CH3 + H20 phosphoric acid methanol methyl phosphate water Formation of a…
A:
Q: Given that the pKa of carbonic acid (H2CO3) is 6.4, is sodium bicarbonate strong enough of a base to…
A: Sodium bicarbonate, NaHCO3(aq) is a conjugate base of carbonic acid, H2CO3(aq). For carbonic acid,…
Q: When a compound with molecular formula C11H14O2 undergoes acid-catalyzed hydrolysis, one of the…
A:
Q: Benzenesulfonyl chloride or p-toluenesulfonylchloride give N-substituted sulfonamides with primary…
A: Benzenesulfonyl chloride reagent is known as Hinsberg reagent. Hinsberg reagent is used for the…
Q: H,N NH COC,H; C. C,H5. 1. C,H,O¯N * 2. H,0 9. 2) \4. C=0 O + 2C,H;OH C,H, NH C,H; COC,H, H,N…
A:
Q: Following is a retrosynthetic analysis for the anthelmintic (against worms) diethylcarbamazine. N.…
A: Diethylcarbamazine is an organic compound used to treat Filariasis. It is formed y treating…
Q: Propose a mechanism for the dehydration of diacetone alcohol to mesityl oxide(a) in acid.
A: In acidic conditions, dehydration follows a mechanism similar to that of other acid-catalyzed…
Q: Explain the observation that attempted Fischer esterification of 2.4,6-trimethylbenzoic acid with…
A: The solution is given below -
Q: 11. Compound A, C9H17N, is an optically inactive alkaloid, containing a tertiary amine that is not…
A: TERTIARY AMINE: It is also known as 3∘ amine. An amine chemical functional group in which nitrogen…
Q: The synthesis of the following compound involves the use of an epoxide. Describe the retrosynthetic…
A: Under acidic condition ring opening of epoxide occurs from the more hindered site.
Q: There are a number of pharmacokinetic strategies available to change the absorption of a lead…
A: Polarity of a molecule can be decreased either by polar groups or introducing non-polar groups
Q: One mole of acetyl chloride is added to a liter of triethylamine, resulting in a vigorous exothermic…
A:
Q: Identify the two major synthetic challenges associated with converting Sudafed PE (over- the-counter…
A: Methamphetamines are potent central nervous system stimulants, a type of drug. Its consumption…
Q: Identify the compound from the infrared spectra. a) 2-Pyridinecarboxaldehyde b) Phenol c)…
A:
Q: 1. Arrange the following compounds in decreasing order of reactivity towards NaI in acetone: I.…
A: Dear Student, According to bartleby guidelines we have to answer first question only(In multiple…
Q: The following scheme shows the retrosynthetic analysis of 1-isopentylaziridine to form series of…
A:
Q: Propose a reagent or reagents to bring about the conversion of F to fluoxetine. Note that the…
A: Given reaction:
Q: How would you change the procedures in this chapter if you wished to synthesize…
A: Given: benzalacetone(C6H5CHCHCOCH3)
Q: yニ,ニ N P 'CI HO, Q んこんこんn S R to `Br
A:
Q: Propose a synthesis for diphenhydramine starting from benzophenone, benzoic acid, and 2-(N,…
A: Synthetic method for diphenhydramine: Benzophenone undergoes reduction using sodium borohydride on…
Q: When a compound with molecular formula C11H14O2 undergoes acid-catalyzed hydrolysis, one of the…
A:
Q: Identify each solvent as either protic or aprotic. N-ethylethanamine (diethylamine)…
A: Answers are explained below. Definition of the Protic & Aprotic solvent is as follows :
Q: General Structure-Function Association for Different Benzodiazepine Modifications. e.g. CH, Methyl…
A: Due to technical error ,unable to provide you the solution. Please resubmit the question once again
Q: 8. N-Phenethylmorphine was synthesised from morphine and found to have enhanced activity. Why does…
A: Option is correct. Only difference with morphine is N-phenethyl moity. The benzene plays important…
Q: Although ibuprofen is sold as a racemic mixture, only the S enantiomer acts as an analgesic. In the…
A: Given:
Q: Identify each solvent as either protic or aprotic. N-ethylethanamine (diethylamine)…
A: Answer is explained below.
Q: Show how you would convert propan-1-ol to the following compounds using tosylateintermediates. You…
A:
Trending now
This is a popular solution!
Step by step
Solved in 2 steps with 1 images
- Draw a structural formula for each amine and amine derivative. (a) N,N-Dimethylaniline (b) Triethylamine (c) tert-Butylamine (d) 1,4-Benzenediamine (e) 4-Aminobutanoic acid (f) (R)-2-Butanamine (g) Benzylamine (h) trans-2-Aminocyclohexanol (i) 1-Phenyl-2-propanamine (amphetamine) (j) Lithium diisopropylamide (LDA) (k) Benzyltrimethylammonium hydroxide (Triton B)Explain the biosynthetic pathway of caffeine to Theobromine in detail?1. (a) There are two main types of adrenergic receptors: the a- and B-adrenoceptors. Noradrenaline shows slight selectivity for the a-adrenoceptor, whereas isoprenaline shows selectivity for the B-adrenoceptor. Adrenaline shows no selectivity and binds equally well to both the a- and B-adrenoceptors. Suggest an explanation for these differences in selectivity. OH OH OH Но. NH2 HO. НО. НО Но Но Noradrenaline Isoprenaline Adrenaline (b) Isoprenaline undergoes metabolism to give the inactive metabolite shown below. Suggest why this metabolite does not bind to the B-adrenoceptor. OH MeO. Но inactive metabolite of Isoprenaline (c) R-Salbutamol is an anti-asthmatic agent that acts as an adrenergic agonist. Do you think it is likely to show any selectivity between the a- and B-adrenoceptors? Explain your answer. OH HOH2C, Но R-Salbutamol
- Compound H (C8H6O3) gives a precipitate when treated with hydroxylamine in aqueous ethanol and a silver mirror when treated with Tollens solution. Following is its 1H-NMR spectrum. Deduce the structure of compound H.Phenacetin, a substance formerly used in over-the-counter headache remedies, has the formula C10H13NO2. Phenacetin is neutral and does not dissolve in either acid or base. When warmed with aqueous NaOH, phenacetin yields an amine, C8H11NO, whose 1H NMR spectrum is shown. When heated with HI, the amine is cleaved to an aminophenol, C6H7NO. What is the structure of phenacetin, and what are the structures of the amine and the aminophenol?A drug which has high affinity for muscarinic receptors not nicotinic receptors and is an antagonist not an agonist: Norepinephrine (LEVOPHED) O Atracurium (TRACURIUM) Echothiophate (PHOSPHOLINE) Ipratropium (ATROVENT) Norepinephrine (LEVOPHED) nint)
- What aldehyde or ketone and nitrogen component are needed to synthesize N-ethylcyclohexanamine by a reductive amination reaction?ADDERAL is composed four salts of enantiomers of amphetamine. Select the four salts from the choices below. Check all correct answers. O Sulfate salt of l-amphetamine O Aspartate salt of l-amphetamine Saccharate salt of d-amphetamine Sulfate salt of d-amphetamine O Hydrochloride salt of d- and l-amphetamine (2 salts)The next drug is an a1 blocker. Which statement is considered true concerning this drug? * O H₂N H₂CO CH3 H₂C The drug is basic The drug has saturated furan ring that enhances its duration of action The drug is a selective nonquinazoline benzene sulfonamide The drug is a selective quinazoline with open piperazine ring
- Paroxetine (Paxil) is an antidepressant that is a member of a family of drugs known as Selective Serotonin Reuptake Inhibitors (SSRIS). This family of drugs also includes fluoxetine (Prozac) and sertraline (Zoloft). SSRIS work by inhibiting the reuptake of the neurotransmitter serotonin in the synapses of the central nervous system follow- ing release of serotonin during excitation of individual nerve cells. Between firings, the serotonin is taken back up by a nerve cell in preparation for firing again. Inhibition of reuptake has the effect of increasing the time serotonin molecules remain in the syn- apses following excitation, leading to a therapeutic effect. In one synthesis of parox- etine, the following reagents are used. Draw the structures of synthetic intermediates A and B. F НО SOCI, A B HO PyridineFollowing are structural formulas for amphetamine and methamphetamine. H NH, CH3 (a) (b) Amphetamine (racemic) Methamphetamine (racemic) The major central nervous system effects of amphetamine and amphetamine-like drugs are locomotor stimulation, euphoria and excitement, stereotyped behavior, and anorexia. Show how each drug can be synthesized by reductive amination of an ap- propriate aldehyde or ketone and amine.What are the derivate reagents for the following compound: MDMA (N-methyl-N-trifluoroacetyl-3,4-methylenedioxyamphetamine)?