None N-Substituted morpholines are building blocks in many drugs. Below is aretrosynthetic analysis of N-methylmorpholine.HO.OH⇒ MeNH2NMeN-MethylmorpholineNMeMethylamineChoose the reagents that will prepare N-methylmorpholine from methylamine in theorder that they are needed. (Select "none" if no additional reagent is needed).(1) ethylene oxide (1 equiv)(2) ethylene oxide (1 equiv)(3)(4)

Let's look into the steps:1. **First step in synthesis:** - Starting with methylamine, to get to…

Answered: N-Substituted morpholines are building…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter22: Carbonyl Alpha-substitution Reactions

Section22.SE: Something Extra

Problem 64AP: The key step in a reported laboratory synthesis of sativene, a hydrocarbon isolated from the mold...

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13:22 4G O 5 ê © T Ô 1. What is the correct IUPAC name for the following compound? Q A. Diphenylamine 1,1 diphenylamine OCN,N-diphenylamine O D. None of the above is correct Add a caption... > Status (Custom) +
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The key step in a reported laboratory synthesis of sativene, a hydrocarbon isolated from the mold Helminthosporium sativum, involves the following base treatment of a keto tosylate. What kind of reaction is occurring? How would you complete the synthesis?
please answer both, will rate. 24) What is the product of the following reaction? C6H5CO₂Et + CH3CH₂CO₂Et A) CH,CCH₂CH₂COET 00 || B) CH,CCHCOÉt A) B) CH3 A) A O A) A B) B c)C. D) D 25) Which of the following is the conjugate base of ethyl butanoate? :0 B) B C) C 0 0 C) CH₂CH₂COCC6H5 (1) NaOCH₂CH3 (2) H₂0* 00 D) CH₂CHCOCC Hs CH3 C) D) el D) D
Rank the following compounds in order of increasing basicity in aqueous solution, least basic first a) Propylamine, ammonium, dipropylamine b) Methyl-3-aminopropanoate, sectutylamine, NH3*CH2CH2NH2 c) Aniline, methyl m-aminobenzoate,, methy! p-aminobenzoate
C) a nitrile D) an amine nitrite salt DIRECTIONS: Each of the following questions or incomplete statements below is followed by four suggested answers lettered A - D. Select or choose the letters of the best answer to the question or incomplete statement. 7. An organic nitrogen compound, X, gives ammonia on warming with dilute aqueous sodium hydroxide, X could be A) ethanamide B) ethylamine C) phenylamine D) amino ethanoic acid Which one of the following reagents reacts 1. in a similar fashion with both phenylamine (C H,NH,) and ethylamine. A) Br,(aq) C) conc. HNO, D) cold HNO (aq) 2. Phenylamine (aniline) can be prepared by reducing nitrobenzene with tin and concerntrated hydrochloric acid followed by the addition of alkali and finally steam distillation. The alkali is added to; A) prevent oxidation of phenylamine. B) liberate free phenylamine from solution C) dissolve excess nitro benzene D) dissolve the phenylamine 8. Arrange the following molecules in their increasing order of base…
Please complete the following question. There is no need to provide an explaination. 20
Although codeine occurs in low concentration in the opium poppy, most of the codeine used in medicine is prepared from morphine (the principal component of opium) by the following reaction. Explain why selective methylation occurs at only one OH in morphine to give codeine. Codeine is a less potent and less addictive analgesic than morphine. но. CH,0. [1 кон H [2] CH3I H. CH3 H Ho morphine H. CH3 Ho codeine
5) Imidazole is more basic than pyridine, but more acidic than pyrrole, why? N.
To preview the image click here Indicate which compound will have highest and lowest Bronsted acidity. 1. Choose the correct option for Highest Bronsted acidity [Select] 2. Choose the correct option for Lowest Bronsted acidity [Select] A B `ОН H3C :0: :0: تصور D
a. What is the amine and coupling components of this azodye? H;CO- -N=N-
Answer the following questions based on the information provided. (a) Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve the ability to exercise in adults with pulmonary arterial hypertension. One of the key step of Sildenafil synthesis is shown below. OEt O OEt O i) Amine HO CHO ii) H20 washing to remove the HCI residue CI N. i) What's the structure of Amine reagent? Amine structure ii) Why does not carboxyl acid react with amine? iii) Draw the mechanism of the reaction.

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