Outline the steps needed to synthesize the tetrapeptide Ala–Leu–Ile–Gly using the Merrifield technique.

Q: Calculate an approximate pI for Peptide E-G-E-A

A: The chemical structure for peptide is shown below.

Q: What reaction conditions are needed to achieve complete peptide hydrolysis to its amino acid…

A: 1- In this question, first we will discuss about Reaction conditions for peptide Hydrolysis, then we…

Q: Indicate the peptides produced from cleavage by the indicated reagent: a.…

A: Concept introduction: Amino acids are linked each other by peptide bonds is called protein (one or…

Q: Deduce the sequence of a heptapeptide that contains the amino acids Ala, Arg, Glu, Gly, Leu, Phe,…

A: Amino acid are the organic compounds which contains both amines  and carboxylic acids within the…

Q: Somatostatin is a tetradecapeptide of the hypothalamus that inhibits the release of pituitary growth…

A: The primary structure of somatostatin has to be deduced,

Q: Which of the following reagents can be used to cleave a tert-butoxycarbonyl (Boc) protecting group…

A: Among the many amino protecting groups, one of the most important protecting group is…

Q: Cleavage of the following peptide with cyanogen bromide would result in the production of smaller…

A:

Q: Deduce the sequence of a heptapeptide that contains the amino acids Ala, Arg, Glu, Gly, Leu, Phe,…

A: The Edman degradation of heptapeptide cleaves amino acid Leu and carboxypeptidase form amino acid…

Q: Show how solid-phase peptide synthesis would be used to make Ile-gly-asn

A: The first step of solid-phase peptide synthesis to make ile-Gly-Asn is shown below.

Q: Which of the following is an acceptable name for the peptide sequence below?

A: While naming the amino acid sequence, start from N-terminal and end on C-terminal, so, it will be…

Q: Explain why the ability of PLP to catalyze an amino acid transformation is greatly reduced if a…

A: The basic step is when PLP catalyzes amino acid's trasformation by the removal of the proton from…

Q: Draw out the peptide IYV and clearly label/identify all the Phi, Psi, and peptide bonds present in…

A:

Q: With reference to the following peptide: (a) Identify the N-terminal and C-terminal amino acids. (b)…

A: (a) In the given ball-and-stick model of amino acid, the black balls represent carbon atoms, the…

Q: Propose a synthesis for the peptide leu-lys-cys

A: Detail synthetic route is given below

Q: Suggest a scheme you will follow to synthesize the dipeptide Ala-Gly

A:

Q: The Arg-Gly-Asp tripeptide (RGD) is a well-known tumour targeting peptide motif. Explain how you…

A: Sythesis of the given peptide from constituent amino acids follows the following steps: 1.…

Q: With reference to the following peptide: (a) Identify the N-terminal and Cterminal amino acids. (b)…

A: In given model the black ball represent carbon atoms, white represent hydrogen atoms, blue…

Q: In a paragraph form, provide the experimental procedures in the chemical synthesis of protein that…

A: Experimental procedures in the chemical synthesis of protein that contain native serine residues by…

Q: In a paragraph form provide the experimental procedure of the reaction of oxazetidine-containing…

A: Proteins are composed of amino acids in which amine group of one amino acid linked to carboxyl group…

Q: Write out a stepwise sequence that shows how a racemic mixture of leucine enantiomers can be…

A:

Q: For the tetrapeptide, Gly-le-Gly-His give (i) the full name of the N-terminal amio acid. (it) full…

A: Please find your solution below : Amino acids are the organic compounds that are mainly composed of…

Q: A peptide has the following amino acid composition: 2 Met, 2 Phe, 2 Glu, 1 Arg, 1 Lys, 1 Val, 1 Leu,…

A: Amino acid are biomolecules which will have both acid group and basic group  We are required to find…

Q: Draw three-dimensional representations of the following amino acids.(a) l-phenylalanine

A: The compounds that contain amine group and carboxyl group attached with a side chain usually alkyl…

Q: draw the structures from a trypsin-catalysed reaction of Ala-Lys-Ser

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Q: A Write the structure of the pentapeptide GL B. What is the complete name of this pentapeptide? Show…

A: A) Pentapeptide GLDSC contains five amino acids i.e, glycine, leucine, aspartic acid, serine, and…

Q: Suppose you are trying to synthesize the dipeptide Val-Ser. Compare the product that would be…

A: Thionyl chloride is used to convert the carboxylic acid into acid chloride.

Q: Draw the structure of the following tripeptide, and label its N-terminal and Cterminal amino acids:…

A: Given, Ala–Gly–Ser

Q: Reaction of the intact peptide with 1-fluoro-2,4-dinitrobenzene followed by hydrolysis creates Ala…

A: 1-fluoro-2,4-dinitrobenzene is Sanger's reagent.

Q: Suggest a scheme you will follow to synthesise the dipeptide Ala-Gly

A:

Q: Which of the following peptides have a net positive chargeat pH 7? (a) Gly-Ser-Lys, (b) Pro-Leu-Ile,…

A: Among the 20 common amino acids, five have a side chain which can be charged. At pH=7, two are…

Q: The configuration of the chiral center in a-amino acids is most commonly specified using the d,l…

A: Introduction To name the enantiomer molecule, R and S configuration is used. The configuration is…

Q: a. histidine b. serine c. aspartate d. valine

A: 1. The oxidation state +2 for iron ion of heme group can be bind to four nitrogen with in a plane.…

Q: Show the steps in the synthesis of the tetrapeptide Leu-Phe-Ala-Val, using Merrifield’s method.

A: Amino acids are linked each other by peptide bonds. Peptide bonds are amide bonds, in which carbonyl…

Q: Decide if the side chains of the following peptides are nonpolar or polar, and label the hydrophobic…

A: Non-polar amino acids are hydrophobic in nature and polar amino acids are hydrophilic in nature. (a)…

Q: What is the structure of below amino acid at its isoelectric point: (a) alanine;

A: Amino acid consists a central carbon atom which is attached to an amine group, (-NH2) and a…

Q: Write out a stepwise sequence that shows how a racemic mixture of leucine enantiomers can be…

A: The given recemic mixture of leucine enantiomers.  The (S)-form and (R)-forms react with the given…

Q: Match the pair of amino acids in first column with the type of side- chain interaction the pair is…

A:

Q: Why is the Alanine predominantly zwitterionic at its PI?

A: The PI is referred to the isoelectric point and is a pH of a solution where the molecule is…

Q: The term used to separate a mixture of enantiomers of amino acids using chiral reagents? A)…

A: When enantiomer of mixture are separated using chiral reagent is called isomeric resolution . In…

Q: Draw the structure of the pentapeptide Met-Pro-Ser-His-Ile at its pl

A:

Q: His-Met-Asp-Tyr-Phe-Ser within this peptide, which amino acid residue is the most hydrophobic and…

A: Hydrophobic amino acids are those with side-chains that do not like to reside in an aqueous…

Q: Draw the structure of below peptide. Label the N-terminal and C-terminal amino acids and all amide…

A: Amino acids are represented using a single capital letter and with three-letter words. The…

Q: Draw three-dimensional representations of the following amino acids.  l-histidine

A: The three-dimensional representation gives the arrangement of bonds in any chemical compound. The…

Q: Suggest a reasonable strategy for the synthesis of the dipeptide Leu-Phe, using established protocol…

A: The biomolecules which have carboxylic and amine group containing monomer units are known as…