P 35. Alpha substitution reactions occur at the position next to the carbonyl group, the a- position. This position is acidic and a strong base can abstract the a-proton forming an enolate anion. This enolate can act as a strong nucleophile to be used in a number of different reactions. Step 2 of the scheme below shows the enolate involved in nucleophilic addition with benzaldehyde. Provide the full mechanism (curved arrows and Intermediates) of the nucleophilic addition reaction that occurs in step 2. H base enolate 1) benzaldehyde 2) H₂O+ OH Ph

P 35. Alpha substitution reactions occur at the position next to the carbonyl group, the a- position. This position is acidic and a strong base can abstract the a-proton forming an enolate anion. This enolate can act as a strong nucleophile to be used in a number of different reactions. Step 2 of the scheme below shows the enolate involved in nucleophilic addition with benzaldehyde. Provide the full mechanism (curved arrows and Intermediates) of the nucleophilic addition reaction that occurs in step 2. H base enolate 1) benzaldehyde 2) H₂O+ OH Ph

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter24: Amines And Heterocycles

Section24.SE: Something Extra

Problem 42MP

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