P9.8: The reaction below proceeds with a direct attack by a water molecule on the substrate, but the hydrolysis could be expected to proceed through two possible mechanisms. Draw two possible mechanisms for the reaction run in H182OH218O. Trace the progress of the 180180 'label' throughout each mechanism to see where it ends up: this should indicate to you how the two mechanisms could be (and in fact were!) distinguished experimentally. ADP OP H2O AMP HO HO НО OH ОН

P9.8: The reaction below proceeds with a direct attack by a water molecule on the substrate, but the hydrolysis could be expected to proceed through two possible mechanisms. Draw two possible mechanisms for the reaction run in H182OH218O. Trace the progress of the 180180 'label' throughout each mechanism to see where it ends up: this should indicate to you how the two mechanisms could be (and in fact were!) distinguished experimentally. ADP OP H2O AMP HO HO НО OH ОН

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter14: Elimination

Section: Chapter Questions

Problem 20E

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